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  • Kojic Dipalmitate
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Kojic Acid Dipalmitate

The Highly Efficient and Stable Whitening Agent

Kojic Acid Dipalmitate (KAD) is an efficient, new generation whitening agent that effectively suppresses the activity of tyrosinase and blocks or delays the formation of melanin. Its esterification with palmitic acid significantly reduces its sensitivity to light and heat, making it less prone to yellowing due to oxidation.

INCI Name

Kojic Acid Dipalmitate

CAS No.

79725-98-7

Source

Derivative of Kojic Acid

Appearance

White crystalline powder

Core Function

Blocks melanin formation, high-efficiency, stable, safe whitening agent.

1. Product Overview & Market Relevance

Kojic Acid Dipalmitate is a new generation of whitening additives developed after Arbutin and Kojic Acid. It offers whitening with anti-oxidant effects, softening the stratum corneum, and is often used by the medical community to fade face spots. It is a high-efficiency, stable, and safe whitening agent.

2. Technical Highlights and Critical Parameters

2.1 Mechanism of Action

  • Tyrosinase Suppression: Blocks melanin formation by suppressing tyrosinase activity (neutral Cu2+), with an effective rate of more than 80%.
  • Stability Improvement: The protection of the active 2,5-hydroxyl groups in the molecular structure by esterification with palmitic acid significantly reduces its sensitivity to light and heat, making it less prone to yellowing due to oxidation.

2.2 Standard Technical Specifications

ParameterSpecification (99% Grade)
Specification99%
AppearanceWhite crystalline powder
Additive quantity1%5%
SolubilityInsoluble in water, oil soluble
Shelf-life24 months
StorageStore in tightly sealed and preferably full containers in cool, dry and ventilated area.

3. Market Positioning and Core Advantages

  • Superior Stability: Demonstrates significantly better stability over $100$ days compared to Kojic Acid and Arbutin.
  • High Efficacy: Suppresses tyrosinase activity with an effective rate of more than 80%.
  • Oil Solubility: Being oil soluble and insoluble in water makes it versatile for different formulation types, especially anhydrous and oil-based systems.
  • Synergy Potential: Shows better complexity when used with vitamin C ethylether and cyanoside.

4. Formulation Guidelines

  • Integration Phase: Since it is oil soluble, it must be dissolved into the oil phase of the formulation. It is insoluble in water.
  • Concentration: Recommended additive quantity is 1%5%.
  • Storage: Requires storage in tightly sealed and preferably full containers in a cool, dry, and ventilated area to maintain its 24-month shelf-life.

5. Quality Assurance and Regulatory Confidence

Our quality and safety credentials include:

  • COSMOS (Natural and Organic Cosmetic Standard)
  • ISO 9001 Quality Management System
  • ISO 22000 Food Safety Management System
  • HALAL Certification
  • IQNET (The International Certification Network)
  • Technical Dossier (Certificate of Analysis – COA, Technical Data Sheet – TDS, Material Safety Data Sheet – MSDS)

6. Typical Applications

  • Cosmetics: Whitening creams, lotions, and serums; anti-aging products, especially those targeting face spots and hyperpigmentation.
  • Formulation Focus: Suitable for oil-based or emulsion systems where high stability is critical.

7. Scientific Evidence Summary

  • Melanin Content Reduction: When the amount of Kojic Acid Dipalmitate is 50ug/ml, the melanin content of B16 cells is reduced to about 68%.

  • B16 Cell Inhibition: When the amount is 5ug/ml, it can significantly inhibit the growth of B16 melanoma cells.

  • Efficacy Rate: Blocks melanin formation with an effective rate of more than 80%.

8.Frequently Asked Questions (FAQ)

Q1: What is the main advantage of Kojic Acid Dipalmitate over Kojic Acid?

A: KAD has significantly improved stability; its structure makes it less sensitive to light and heat, thus reducing yellowing due to oxidation.

Q2: Is this ingredient water soluble?

A: No, Kojic Acid Dipalmitate is insoluble in water but is oil soluble.

Q3: How effective is KAD in inhibiting melanin formation?

A: It blocks melanin formation by suppressing tyrosinase activity with an effective rate of more than 80%.

 

Source our 99 Percent Purity Kojic Acid Dipalmitate for a highly stable, oil-soluble, and effective solution against skin hyperpigmentation.

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