Dipotassium Glycyrrhizinate

Huatai Bio offers premium Dipotassium Glycyrrhizate with high purity up to 99%, sourced from natural licorice root and fully compliant with US FDA GRAS and Japanese cosmetic standards for heavy metal control. As a direct manufacturer, we provide 100% water-soluble, stable stock solutions and complete technical dossiers—including COA, MSDS, and TDS—to ensure your formulation’s safety and performance from day one.

1. Product Overview & Key Specifications

Dipotassium Glycyrrhizate (DG) is not just a licorice extract; it is the gold standard for anti-inflammatory and anti-irritant solutions in modern skincare. Derived from natural licorice root, our DG acts as a powerful bioactive agent that:

• Instantly Calms: Reduces redness and stinging caused by chemical or environmental stressors.

• Protects the Barrier: Maintains hyaluronic acid levels in the skin to prevent transepidermal water loss.

• Enhances Stability: Acts as a co-emulsifier and gelling agent, improving the sensory profile of your final product.

2. Technical Highlights & Critical Parameters

We provide the hard data R&D teams need to ensure seamless formulation and superior performance.

2.1 Dipotassium Glycyrrhizate Safety & Technical Data

• Safety Status: Recognized as GRAS (Generally Recognized As Safe) by the US Food and Drug Administration (FDA). Clinical tests confirm DG does not penetrate or irritate the skin and is non-toxic.
• Global Compliance: Approved as an OTC Personal Care additive by the European Cosmetics Directive and the CIR (Cosmetic Ingredient Review) Expert Panel.
• Heavy Metal Control: Our DG is manufactured to Japanese cosmetic standards, with heavy metal levels strictly controlled below the regulatory safety limit.

2.2 Customizable Grade Options

Storage Condition: Avoid light, ventilation, dry, in a sealed space.

3. Mechanism of Action (MoA)

DG is a multifunctional restorative agent:

• Anti-Inflammatory & Soothing: DG provides effective relief from skin irritation and promotes the recovery of stressed skin conditions.
• Antiallergic: It helps improve skin tolerance and reduces sensitivity.
• Antibacterial: DG inhibits bacterial growth, effectively preventing inflammation and infection.

4. Core Advantages & Market USPs

4.1 Competitive Edge for Your Brand

• Highest Safety Profile: Backed by US FDA GRAS status and rigorous clinical testing confirming non-penetration and non-irritation.
• Effective Soothing Power: Proven to alleviate irritation, sensitivity, and pain caused by skin stressors (SDS).
• High Purity & Quality: Offered in concentrations up to $99\%$, ensuring high efficacy and compliance with Japanese cosmetic standards for heavy metal control.
• Water Soluble Convenience: Easily incorporated into diverse cosmetic formulations, including serums, toners, and creams.

5. Formulation Guidelines

• Recommended Use Level: 0.1% – 5% across all grades (73%, 75%, 99%).
• Dissolution Advice: As a water-soluble white powder, DG can be easily dissolved into the aqueous phase of your formulation.
• Compatibility: Highly compatible with a wide range of cosmetic bases and other functional ingredients.

6. Quality Assurance & Regulatory Confidence

We are committed to the highest standards of quality and regulatory compliance.

6.1 Certificate Section

Our quality and safety credentials include:

• COSMOS (Natural and Organic Cosmetic Standard)
• ISO 9001 Quality Management System
• ISO 22000 Food Safety Management System
• HALAL Certification
• IQNET (The International Certification Network)
• Technical Dossier (Certificate of Analysis – COA, Technical Data Sheet – TDS, Material Safety Data Sheet – MSDS)

7. Recommended Synergistic Combinations

• Dipotassium Glycyrrhizate + Centella Asiatica Extract: Maximize skin soothing, repair, and wound healing benefits.
• Dipotassium Glycyrrhizate + Hyaluronic Acid: Combines soothing relief with superior hydration retention.

8. Typical Applications & Success Stories

• Industry Validation: Used extensively in sensitive skin, baby care, and post-procedure recovery products globally.
• Product Categories: Soothing Serums, Anti-irritation Creams, Sunscreen Formulations (to mitigate $\text{UV}$-induced irritation), Baby Products, Toner/Essences.

9. Scientific Evidence & Literature Support

Based on internal lab summaries, our Dipotassium Glycyrrhizate provides reliable anti-irritation results:

9.1 Research Abstracts

• SDS Irritation Alleviation: An assessment using 5% SDS patch irritation on volunteers demonstrated that treatment with various concentrations of Dipotassium Glycyrrhizate (DG) effectively reduced skin irritation, stinging, and thermal sensation.
  • Key Data: The discomfort associated with stinging, irritation, and thermal sensation decreased as the DG concentration increased. The 0.7% DG concentration showed the most significant improvement effect on skin redness, irritation, and thermal discomfort.

• Anti-Irritation Mechanism: Experimental results confirm that DG can effectively alleviate skin irritation caused by SDS. Furthermore, the improvement effect increases in a concentration-dependent manner.

10. Stability and Safety Data Summary

• Safety Profile: DG has high intrinsic safety, recognized by the FDA and CIR. It is non-penetrative, non-irritating, and non-toxic.
• Stability: As a powder grade, DG guarantees a 24-month shelf life when stored under recommended dry, sealed, and light-avoiding conditions.

11. Frequently Asked Questions (FAQ)

Q1: Does Dipotassium Glycyrrhizate require specific handling during formulation?

A: No. As a highly soluble white powder, it is very easy to incorporate directly into the aqueous phase of most formulations at ambient temperature.

Q2: What is the primary benefit of the 99% purity grade?

A: The 99% purity ensures the highest concentration of the active compound, maximizing efficacy, providing precise dosing control, and meeting the strictest regulatory requirements.

Q3: Can DG be used in conjunction with strong active ingredients like Retinol?

A: Yes. DG is often used as a core soothing agent in formulas containing potentially irritating ingredients (like Retinoids or high-concentration AHAs) to mitigate side effects.

Q4: Is your DG compliant with baby care or sensitive skin product standards?

A: Absolutely. Our DG’s high safety profile, GRAS status, and proven anti-irritation effects make it ideal for the most sensitive skin and baby care products.

Secure the Globally Trusted Soothing Solution for Your Formulations.

🔒 Get Your Technical Dossier: Access TDS, MSDS, COA and Safety Reports.

🔬 Apply for a Free Sample: Test the superior soothing power of DG today.

📞 Get a Customized Quote: Discuss bulk orders and tailored purity specifications.