Supplier of high-purity functional skin care ingredients

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Shaanxi Huatai Bio-Fine Chemical Co., Ltd.

Licochalcone A

The Powerful Anti-Inflammatory and Anti-Aging Chalcone

A highly valuable compound extracted from the Licorice plant, Licochalcone A (LA) is a powerful multifunctional ingredient known for reducing ROS levels, inhibiting inflammation, and offering antibacterial effects against organisms like Staphylococcus aureus. It is essential for advanced anti-aging and sensitive skin formulations.

CAS No.	58749-22-7
Source	Natural Plant Extract (Licorice Root/Stem)
Appearance Color	Brownish Yellow Powder
Key Efficacy	Anti-Aging, Anti-Inflammation, Anti-Bacterial
Purity	Up to 95% (High Purity Powder)
Solubility	Alcohol Soluble

1. Product Overview & Key Specifications

Licochalcone A is a chalcone-type compound found in the Licorice plant. Our Licochalcone A is predominantly extracted from the Licorice root and stem, as these parts are richer in Licochalcone A than leaves and seeds. Due to its complex structure, it is a high-cost, high-value ingredient. It is an effective solution for reducing the occurrence of inflammatory skin diseases.

2. Technical Highlights & Critical Parameters

We provide the hard data R&D teams need to ensure seamless formulation and superior performance.

2.1 Licochalcone A Core Efficacy

Anti-Aging & ROS Reduction: Licochalcone A reduces ROS (Reactive Oxygen Species) levels and inhibits telomere shortening, which are primary factors in cellular senescence.
Anti-Inflammatory Action: LA can inhibit the synthesis of $\text{NO}$ (Nitric Oxide) and the expression of iNOS (inducible Nitric Oxide Synthase) and $\text{COX}-2$ (Cyclooxygenase-2). This prevents the release of pro-inflammatory factors and reduces the frequency of inflammatory skin issues.
Broad Application: Licochalcone A is suitable for combating various skin inflammations, such as pediatric atopic dermatitis and photo-inflammation caused by UV radiation.

2.2 Customizable Grade Options

Content	Physical Form	Solubility	Recommended Use Level	Shelf Life
20%	Brownish Yellow Powder	Alcohol Soluble	0.1% – 2%	24 Months
70%	Brownish Yellow Powder	Alcohol Soluble	0.1% – 2%	24 Months
95%	Brownish Yellow Powder	Alcohol Soluble	0.1% – 2%	24 Months

Storage Condition: Avoid light, ventilation, dry, in a sealed space.

3. Mechanism of Action (MoA)

LA primarily works by downregulating inflammatory pathways and combating oxidative stress at the cellular level. Its mechanism includes:

Reducing $\text{ROS}$ Levels that lead to cellular senescence.
Inhibiting the release of pro-inflammatory factors to prevent skin inflammation.
Inhibiting Tyrosinase activity while showing clear inhibition against Staphylococcus aureus.

4. Core Advantages & Market USPs

4.1 Competitive Edge for Your Brand

Multi-Functional Power: Simultaneously delivers Anti-Aging, Anti-Inflammatory, and Antibacterial benefits.
Targeted Anti-Aging: Directly targets the root cause of aging by reducing $\text{ROS}$ and inhibiting telomere shortening.
High Purity (up to 95%): Ensures potent efficacy for advanced formulations.
Natural Anti-Inflammatory: An excellent natural solution for sensitive, reactive, and acne-prone skin.

5. Formulation Guidelines

Recommended Use Level: $0.1\% - 2\%$ across all grades.
Dissolution Advice: As an alcohol-soluble powder, it should be pre-dissolved in the alcohol or oil phase of the formulation.
High Purity Benefits: The $95\%$ purity grade is ideal for highly targeted serums and spot treatments.

6. Quality Assurance & Regulatory Confidence

We are committed to the highest standards of quality and regulatory compliance.

6.1 Certificate Section

Our quality and safety credentials include:

COSMOS (Natural and Organic Cosmetic Standard)
ISO 9001 Quality Management System
ISO 22000 Food Safety Management System
HALAL Certification
IQNET (The International Certification Network)
Technical Dossier (Certificate of Analysis – COA, Technical Data Sheet – TDS, Material Safety Data Sheet – MSDS)

7. Recommended Synergistic Combinations

Licochalcone A + Ceramides: Combines anti-inflammatory repair with skin barrier restoration.
Licochalcone A + Niacinamide: Synergistic in combating acne, redness, and inflammation.

8. Typical Applications & Success Stories

Industry Validation: Used in high-end derma-cosmetic brands targeting sensitive, acne, and redness-prone skin.
Product Categories: Anti-Aging Serums, Sensitive Skin Toners, Anti-Redness Creams, Post-Procedure Care.

9. Scientific Evidence & Literature Support

Based on internal lab summaries, our Licochalcone A provides powerful cellular protection:

9.1 Research Abstracts

Anti-Aging and $\text{ROS}$ Reduction: High $\text{ROS}$ levels are a primary cause of cellular senescence. Compared to the control group, Licochalcone A $\text{LA}$ at a concentration of 25 $25 \mu \text{mol/L}$ significantly reduced the $\text{ROS}$ level in $\text{hADSCs}$ (human adipose-derived stem cells) and suppressed telomere shortening ( $P < 0.05$ ). This indicates its protective role against aging.

Anti-Inflammatory Mechanism: LA reduces the release of pro-inflammatory factors, which helps prevent skin inflammation.
Dual Action: LA demonstrates the function of inhibiting tyrosinase activity and exhibits a clear inhibitory effect on Staphylococcus aureus.

10. Stability and Safety Data Summary

Safety: Derived from natural licorice, LA is generally well-tolerated and is used in sensitive skin products globally.
Stability: All powder grades (20%, 70%, 95%) guarantee a 24-month shelf life when stored under recommended conditions.

11. Frequently Asked Questions FAQ

Question	Answer
What is Licochalcone A and what are its primary benefits in skincare?	Licochalcone A is a highly potent flavonoid extracted from licorice root. It effectively targets acne causing bacteria reduces severe skin inflammation and controls excess sebum production. Shaanxi Huatai manufactures high purity Licochalcone A to help cosmetic brands develop advanced acne treatment and soothing formulations.
What is the purity specification and appearance of your Licochalcone A raw material?	Quality and consistency are our top priorities for B2B procurement. Shaanxi Huatai supplies cosmetic grade Licochalcone A standardized to exceptional purity levels. Our bulk product appears as a fine yellow powder ensuring maximum safety biological activity and stable formulation for your high end product lines.
Is your Licochalcone A water soluble and how should it be formulated?	Licochalcone A is naturally lipophilic and insoluble in water. The technical formulation team at Shaanxi Huatai recommends pre dissolving it in suitable cosmetic glycols like butylene glycol or incorporating it into the oil phase of your acne serums and soothing creams during processing to ensure a highly stable and homogeneous final product.
What is the recommended usage rate for Licochalcone A in cosmetic manufacturing?	For daily acne creams intensive soothing serums and sebum control lotions the recommended usage rate typically ranges from 0.1 to 1.0 percent depending on the specific product application. The technical formulation experts at Shaanxi Huatai can provide precise dosage guidelines tailored to your commercial project requirements.
Why is Licochalcone A widely favored for acne prone and rosacea formulations?	Licochalcone A is highly regarded for its dual action ability to inhibit acne bacteria and rapidly calm deep skin inflammation. Its incredible soothing capacity makes it highly effective for reducing visible redness and recovering compromised acne prone skin. Shaanxi Huatai provides high purity active ingredients ideal for crafting safe highly effective products for reactive skin types.
Can Licochalcone A be combined with other active ingredients like Salicylic Acid or Niacinamide?	Absolutely. Licochalcone A works synergistically with a wide range of exfoliating and barrier repairing actives. The formulation team at Shaanxi Huatai frequently assists global clients in combining our Licochalcone A with Salicylic Acid Niacinamide or Centella Asiatica to create comprehensive blemish control and skin soothing complexes.
Do you provide the Certificate of Analysis COA and MSDS for wholesale bulk orders?	Absolute regulatory compliance and strict quality control are our core manufacturing standards. Shaanxi Huatai provides comprehensive batch specific documentation for every wholesale shipment globally including the Certificate of Analysis COA Material Safety Data Sheet MSDS and detailed purity testing reports.
What is your Minimum Order Quantity MOQ and are testing samples available for labs?	To support independent formulation labs and large scale commercial manufacturing facilities alike Shaanxi Huatai offers a highly accessible MOQ starting at just 1kg. We also gladly provide 10g to 50g free testing samples so your research team can thoroughly evaluate formulation compatibility before ordering in bulk.

Source the Advanced Natural Chalcone for Next-Generation Anti-Aging Formulas.

🔒 Get Your Technical Dossier: Access TDS, MSDS, COA and Safety Reports.
🔬 Apply for a Free Sample: Test the anti-inflammatory power of Licochalcone A today.
📞 Get a Customized Quote: Discuss bulk orders and high-purity specifications.

Empower Your Skin Science: Develop Next-Generation Formulations with Our Premium Active Ingredients.

Why choose us

Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.

Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.

Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.

Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.