
Papain is a powerful, naturally derived proteolytic enzyme extracted from the raw fruit of the papaya plant (Carica papaya). Its key cosmetic efficacy lies in its ability to selectively digest dead keratin proteins on the skin’s surface, providing gentle, non-abrasive exfoliation. This leads to immediate improvements in skin texture, radiance, and clarity, making it a highly effective and mild active for formulations targeting dullness, uneven texture, and congested pores.
| INCI Name | Papain |
|---|---|
| CAS No. | 9001-73-4 |
| Origin | Extracted from Carica papaya fruit |
| Appearance | Light yellow to pale beige powder |
| Enzyme Activity | ≥ 1000 U/mg (customizable) |
| Odor | Mild characteristic fruity scent |
| Solubility | Easily soluble in water, suitable for aqueous formulations |
| Recommended Usage | 0.1% – 1% |
| pH Stability | 4.0 – 7.0 |
| Packaging | 1kg / 5kg / 25kg foil bags or fiber drums |
Clinically proven to accelerate epidermal desquamation by 35% without disrupting the skin barrier, delivering high-potency proteolytic exfoliation that resolves hyperkeratosis, dullness, and congestion with zero risk of acid-induced chemical burns or systemic sensitization.
In the advanced landscape of clinical exfoliation and dermatological resurfacing, delivering professional-grade cell turnover without the inflammatory “sting” or barrier-compromise associated with AHAs and BHAs is the ultimate formulation challenge. As a specialized high-purity cosmetic active ingredient manufacturer established in 2008, Shaanxi Huatai Bio-Fine Chemicals Co. delivers a premium Papain Enzyme rigorously engineered to ensure ultra-high enzymatic purity and completely remove residual allergen-protein complexes. Built to be 100% farnesol-free, it establishes a flawless safety profile that eradicates the risk of ingredient-induced sensitization. By functioning as a high-potency, selective cysteine protease, this ultra-pure active provides professional-grade keratinolysis, improved penetration of subsequent actives, and profound textural refinement for even the most hyper-reactive, compromised skin.
For Global OEM/ODM Innovators: Achieve ultimate formulation elegance and versatility. Our high-purity Papain is engineered for superior water solubility and optimized enzymatic kinetics, ensuring seamless integration into your high-performance delivery systems, including anhydrous cleansing powders, enzymatic peel-masks, and stabilizing treatment balms. It offers exceptional stability within the optimal pH 5.0–7.0 window, ensuring your R&D teams can deliver consistent, reliable performance across complex multi-active formulations without the pH-related manufacturing friction typical of chemical acid exfoliants. Its refined, odorless, and color-neutral profile guarantees it will never interfere with your brand’s signature product aesthetics.
For High-End Beauty Brands: Elevate your market positioning and clinical claims. This ultra-pure, standardized bioactive is the signature choice for strict “Clean Beauty” mandates and highly tolerable “SOS Emergency Repair” formulations. Empower your brand to market “Professional-Grade Enzymatic Resurfacing,” “Non-Acidic Texture Refinement,” and “Sensitive-Skin Radiance” without the risks linked to synthetic chemical peels. Capture the fierce loyalty of consumers demanding highly potent, non-sensitizing clinical solutions that deliver flawless skin uniformity, instant smoothing, and essential everyday structural safety.
Appearance: Refined, high-purity white crystalline powder (optimized for aesthetic integration)
Active Content: Standardized to ultra-high enzymatic activity (verified for maximum proteolytic power and desquamation efficacy)
Heavy Metals: < 10 ppm
Arsenic: < 1 ppm
Recommended Dosage: 0.1% – 1.0% (Highly potent for daily gentle resurfacing or intensive mask protocols)
pH Stability: Highly stable across the optimal pH range of 5.0 – 7.0
Processing Guidelines: Water-soluble. Readily dissolves into aqueous-phase cool-down steps or serves as the core active in anhydrous powder-to-foam cleansers. Compatible with most cosmetic systems, including chelating agents (EDTA) for enhanced stability.
Provide your R&D laboratory with an instant blueprint for market success. Our Papain Enzyme acts as a supreme biological “resurfacing engine,” protecting and amplifying the restorative efficacy of companion actives:
Papain + Allantoin: The ultimate “Gentle Resurfacing & Soothing” matrix. Combines the targeted proteolytic action of Papain with the tissue-soothing properties of Allantoin to rapidly resolve surface dullness and congestion, neutralizing the inflammatory potential of traditional exfoliation while restoring equilibrium to hyper-reactive skin.
Papain + Panthenol: A comprehensive “SOS Barrier-Resurfacing” system. Panthenol floods the stratum corneum with deep, targeted hydration, creating a healthy, non-reactive environment that allows Papain to effectively refine texture without triggering moisture-barrier tightness or reactivity.
Papain + Ceramide NP: The absolute structural longevity and “Clean Beauty Defense” complex. While Papain works fundamentally from within to clear the dead-cell barrier, Ceramide NP safely and physically rebuilds the skin’s depleted lipid cement on the surface, ensuring a resilient, smooth, and perfectly defended skin barrier.
Formulate with absolute regulatory confidence. We strictly adhere to global cosmetic safety benchmarks, ensuring our active ingredients pass the most stringent toxicological assessments. Our state-of-the-art manufacturing facility operates under the highest global standards, fully certified by:
ISO9001
ISO22000
COSMOS
HALAL
IQNET
Every batch is supported by a comprehensive technical dossier to streamline your global compliance, supply chain transparency, and regulatory filing processes.
Stop compromising on formula stability, volatile botanical extracts, and ingredient-induced irritation. Protect your consumers and elevate your product lines with the global standard in highly stable, non-sensitizing clinical resurfacing actives.
Claim your High-Purity Sample Now and upgrade your next blockbuster SOS repair formula! Contact our technical sales team immediately to secure your free lab sample, request a customized bulk quote, and access the full Technical Dossier (TDS, MSDS, COA, and Clinical Efficacy Reports).
Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.
Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.
Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.
Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.




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