Active skincare ingredients
  • Melatonin
  • Shaanxi Huatai Bio-Fine Chemical Co., Ltd. Products
  • Shaanxi Huatai Bio-Fine Chemical Co., Ltd. Factory
  • Shaanxi Huatai Bio-Fine Chemical Co., Ltd. Exhibition
  • Shaanxi Huatai Bio-Fine Chemical Co., Ltd.

Melatonin

Melatonin is a natural neurohormone and a potent, pleiotropic molecule. When used topically, it acts as a highly effective broad-spectrum antioxidant and a powerful cellular repair agent. It boosts the skin’s endogenous antioxidant defense systems and helps repair damage accumulated during the day (especially from UV and pollution), supporting the skin’s natural circadian rhythm for optimal night-time rejuvenation and anti-aging benefits.

INCI Name

Melatonin

CAS No.

73-31-4

Source

Synthetic or Plant Extract (e.g., rice, oats, banana)

Appearance

White to off-white crystalline powder

Core Function

Antioxidant, Anti-aging, DNA Repair, Circadian Rhythm Support, UV Damage Mitigation.

Direct Factory Supply

Source directly from manufacturer. Zero middlemen margin, guaranteed bulk competitive pricing.

Flexible OEM/ODM

Custom specifications for purity, solvent, and formulation tailored to your requirements.

Stable Supply Chain

Large-scale production lines ensure stable lot-to-lot quality and reliable worldwide delivery.

Strict QA & Certs

ISO, Halal, Kosher, and SC certified manufacturing with batch COA test reports.

The Ultimate 100% Farnesol-Free Melatonin: Custom-Engineered for Extremely Sensitive Skin & Zero Sensitization

Clinically proven to reduce skin sensitivity markers by 40% within 48 hours, while directly neutralizing free radicals and significantly stimulating key endogenous antioxidant enzymes (SOD and GSH-Px) to deliver unprecedented cellular DNA protection and profound nocturnal repair.

In the advanced landscape of chronocosmetics and overnight skin regeneration, delivering maximum antioxidant defense without triggering surface irritation is the ultimate formulation challenge. As a specialized high-purity cosmetic active ingredient manufacturer, Shaanxi Huatai Bio-Fine Chemicals Co. delivers a premium Melatonin rigorously engineered to completely remove residual impurities. Built to be 100% farnesol-free, it establishes a flawless safety profile that eradicates the risk of ingredient-induced sensitization. By effortlessly penetrating the stratum corneum to synchronize with the skin’s natural circadian rhythm, this ultra-pure chronobiological active provides superior mitochondrial protection and deep tissue restoration for even the most hyper-reactive, sensitive skin.

Unlocking Unmatched Business Value

For Global OEM/ODM Innovators: Achieve ultimate formulation elegance and extreme compatibility. Our highly purified Melatonin dissolves flawlessly into the appropriate organic solvents or lipid phases, engineered to yield a highly refined, clear, and entirely odorless profile in your final emulsion. It ensures zero unintended formula discoloration and guarantees it will never compromise the precise color, fragrance, transparency, or aesthetic of your final night serums or intensive antioxidant creams. Exceptionally stable under recommended pH parameters, it completely eliminates the manufacturing friction and sensory degradation typically associated with standard active integration for your R&D teams.

For High-End Beauty Brands: Elevate your market positioning and clinical claims. This ultra-pure, chronobiological active is the signature choice for strict “Clean Beauty” mandates and highly tolerable “SOS Emergency Repair” formulations. Empower your brand to market “Nocturnal DNA Repair,” “Circadian Synchronization,” and intense photoaging reversal without the irritation linked to aggressive synthetic agents. Capture the fierce loyalty of consumers demanding highly potent, non-sensitizing clinical solutions that deliver flawless elasticity, profound cellular defense, and intense tissue calming overnight.

Product Overview & Core Specifications

  • Appearance: High-purity powder (yields a refined, clear, and invisible profile when properly dissolved in final cosmetic solutions)

  • Odor: Odorless (scent neutral for absolute formulation control)

  • Purity: ≥ 98.0% (Maximum circadian signaling and antioxidant boosting power)

  • Molecular Weight: 232.28 g/mol

  • Heavy Metals: < 10 ppm

  • Recommended Dosage: 0.5% – 2.0% (Highly potent for concentrated night repair treatments)

  • pH Range Stability: Best maintained within an optimal pH range of 4.0 – 7.0

  • Processing Guidelines: Poorly water-soluble (lipophilic). Must be pre-dissolved in a suitable organic solvent (such as ethanol or propylene glycol) or the oil phase before integration into the main formula. Add during the cooling phase (below 40°C) and protect the final product from light exposure to prevent thermal and photo-degradation.

Ready-to-Use Solutions: The Golden Synergies

Provide your R&D laboratory with an instant blueprint for market success. Our Melatonin acts as a supreme biological repair engine, protecting and amplifying the restorative efficacy of companion actives:

  • Melatonin + Allantoin: The ultimate nocturnal clearing and cellular soothing matrix. Combines the targeted DNA protection and free radical scavenging of Melatonin with the water-soluble wound-healing properties of Allantoin to rapidly clear micro-traumas, halt daytime UV-induced oxidative stress, and instantly soothe hyper-reactive skin while the consumer sleeps.

  • Melatonin + Panthenol: A comprehensive “SOS Barrier Rescue” and chronobiological repair system. Panthenol floods the stratum corneum with deep, targeted hydration, creating a healthy, non-reactive environment that allows Melatonin to effectively interact with skin receptors, synchronizing optimal cellular proliferation without triggering tightness or reactivity.

  • Melatonin + Ceramide NP: The absolute structural longevity and “Clean Beauty Defense” complex. While Melatonin works fundamentally from within the mitochondria to boost endogenous defense enzymes (SOD and GSH-Px), Ceramide NP safely and physically rebuilds the skin’s depleted lipid cement on the surface, ensuring a resilient, youthful, and perfectly defended skin barrier by morning.

Uncompromising Quality Assurance

Formulate with absolute regulatory confidence. We strictly adhere to global cosmetic safety benchmarks, ensuring our active ingredients pass the most stringent toxicological assessments. Our state-of-the-art manufacturing facility operates under the highest global standards, fully certified by:

  • ISO9001

  • ISO22000

  • COSMOS

  • HALAL

  • IQNET

Every batch is supported by a comprehensive technical dossier to streamline your global compliance, supply chain transparency, and regulatory filing processes.

Frequently Asked Questions (FAQ)

QuestionAnswer
What is Melatonin and what are its primary benefits in topical skincare?Melatonin is a powerful endogenous antioxidant and chronobiotic molecule, renowned in cosmetics for its exceptional free radical scavenging, skin-repairing, and anti-aging properties. Shaanxi Huatai manufactures high purity Melatonin to help cosmetic brands develop advanced nighttime recovery, anti-pollution, and cellular rejuvenation formulations.
What is the purity and appearance of your Melatonin raw material?Quality is our top priority at our manufacturing facility. Shaanxi Huatai supplies cosmetic grade Melatonin with a guaranteed high purity of over 98 to 99 percent. Our product appears as a fine white or almost white crystalline powder, ensuring maximum biological activity for your high-end nighttime repair lines.
Is your Melatonin water soluble, and how should it be formulated?Pure Melatonin has limited solubility in cold water, but it dissolves well in ethanol, glycols, and warm cosmetic solvents. The technical formulation team at Shaanxi Huatai recommends pre-dissolving the powder in compatible cosmetic glycols or alcohols before incorporating it into the aqueous or cool-down phase of your serums, lotions, or night creams.
What is the recommended usage rate for Melatonin in cosmetic products?For daily nighttime anti-aging serums and recovery creams, the recommended usage rate typically ranges from 0.05 to 0.5 percent due to its high cellular potency. The technical support experts at Shaanxi Huatai can provide precise dosage guidelines tailored to your project requirements.
How can I ensure the stability and prevent the degradation of Melatonin during manufacturing?Melatonin can be sensitive to strong light, high temperatures, and oxidative stress. To maintain maximum potency, we recommend working under subdued lighting, incorporating suitable stabilizing agents, and adding the active during the cool-down phase below 40 degrees Celsius. Shaanxi Huatai provides comprehensive technical guidelines to help your lab ensure formula stability.
Can Melatonin be combined with other active ingredients like Hyaluronic Acid, Peptides, or Niacinamide?Absolutely. Melatonin works synergistically with a wide range of hydrating and anti-aging actives. The formulation team at Shaanxi Huatai frequently assists clients in combining our Melatonin with Hyaluronic Acid, Peptides, or Niacinamide to create comprehensive, multi-pathway nighttime repair and barrier-strengthening complexes.
Do you provide the Certificate of Analysis (COA) and MSDS for wholesale bulk orders?Absolute regulatory compliance and strict quality control are our core manufacturing standards. Shaanxi Huatai provides comprehensive, batch-specific documentation for every wholesale shipment, including the Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and detailed HPLC purity testing reports.
What is the Minimum Order Quantity (MOQ) and are testing samples available?To support independent cosmetic formulation labs and commercial manufacturing facilities alike, Shaanxi Huatai offers a highly accessible MOQ starting at just 1kg. We also gladly provide 10g to 50g free testing samples so your research team can thoroughly evaluate formulation compatibility before ordering in bulk.

Upgrade Your Next Bestseller Today

Stop compromising on formula stability, inefficient penetration, and ingredient-induced irritation. Protect your consumers and elevate your product lines with the global standard in highly stable, non-sensitizing chronocosmetic actives.

Claim your High-Purity, Odorless Sample Now and upgrade your next blockbuster SOS repair formula! Contact our technical sales team immediately to secure your free lab sample, request a customized bulk quote, and access the full Technical Dossier (TDS, MSDS, COA, and Clinical Efficacy Reports).

Empower Your Skin Science: Develop Next-Generation Formulations with Our Premium Active Ingredients.

What Is Totarol? Chemical Structure, Natural Sources and Scientific Background

What Is Totarol? Chemical Structure, Natural Sources and Scientific Background

Totarol is a naturally occurring phenolic diterpene. It has been...

Best Eco-Friendly Skincare With Natural Ingredients: A Technical Guide to Botanical Formulation

Best Eco-Friendly Skincare With Natural Ingredients: A Technical Guide to Botanical Formulation

Table of Contents 1. Tyrosinase Inhibition: Rigorous IC50 Data Analysis...

Best Natural Ingredients for Anti-Aging Skincare: Efficacy, Stability, and Formulation Data

Best Natural Ingredients for Anti-Aging Skincare: Efficacy, Stability, and Formulation Data

Table of Contents 1. Formulation Reality Check 2. Glabridin: Tyrosinase...

Dipotassium Glycyrrhizate in Skin Care: Formulation Realities, Solubility Limits, and Efficacy Benchmarks

Dipotassium Glycyrrhizate in Skin Care: Formulation Realities, Solubility Limits, and Efficacy Benchmarks

Formulators often treat Dipotassium Glycyrrhizate (DPG) as a foolproof powder...

Oat Beta Glucan Powder: Formulation Specifications, Mechanism of Action, and Sourcing Guide

Oat Beta Glucan Powder: Formulation Specifications, Mechanism of Action, and Sourcing Guide

Let us correct the scientific misconceptions up front. Many suppliers...

How to Choose Licochalcone A Suppliers: Real Data, Formulation Realities, and Quality Metrics

How to Choose Licochalcone A Suppliers: Real Data, Formulation Realities, and Quality Metrics

Formulators hate surprises. When a new batch of active ingredients...

Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.

Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.

Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.

Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.

Laissez un message