
The Ultra-Fast Neuro-Soothing Specialist for Stinging and Redness Relief
Liquiritigenin is a high-purity flavonoid aglycone derived from Licorice (Glycyrrhiza glabra). It is a premium cosmetic grade active specifically engineered to address “Neurogenic Inflammation”—the immediate stinging and burning sensations often felt by sensitive skin. By targeting the sensory nerve response, it provides a “lightning-fast” calming effect and visibly reduces transient redness.
| CAS No. | 578-86-9 |
|---|---|
| Source | High-Purity Licorice Root Extraction |
| Appearance Color | White to Off-white Crystalline Powder |
| Key Parameter | Purity ≥ 98.0% / Fast-Acting Sensory Relief |
| Solubility | Soluble in Ethanol and Glycols; Partially Water-Soluble |
Clinically proven to reduce perceived stinging and neurogenic irritation by 60% within just 3 minutes, instantly switching off visible redness and discomfort.
In the advanced dermatological skincare sector, providing instant relief without triggering further irritation is the ultimate formulation challenge. Our premium Cosmetic-Grade Liquiritigenin is rigorously engineered to completely remove impurities. Built to be 100% farnesol-free, it establishes a flawless safety profile that eradicates the risk of ingredient-induced sensitization. By selectively modulating TRPV1 receptors (the skin’s heat and pain sensors), this high-purity flavonoid aglycone halts the inflammatory cascade, neutralizes free radicals, and delivers immediate sensory comfort to hyper-reactive skin.

For Global OEM/ODM Innovators: Achieve ultimate formulation elegance and extreme compatibility. Unlike crude, dark licorice extracts, our highly purified Liquiritigenin integrates seamlessly without significantly darkening the final product. It delivers a refined, entirely odorless profile and water-white clarity when properly formulated, ensuring it will never compromise the precise color, fragrance, or aesthetic of your final emulsion. Exceptionally stable in air and light, it completely eliminates manufacturing friction for your R&D teams.
For High-End Beauty Brands: Elevate your market positioning and clinical claims. This ultra-pure active is the signature choice for strict “Clean Beauty” mandates and highly tolerable “SOS Emergency Repair” formulations. Empower your brand to market “First-Aid” soothing and “Anti-Stinging” miracles. Capture the fierce loyalty of consumers demanding highly potent, non-sensitizing neuro-calming care that delivers visible redness reduction and sensory dampening within minutes of application.
Appearance: Refined high-purity powder (clear formulation friendly; avoids crude extract darkening)
Odor: Odorless (scent neutral)
Purity: ≥ 98.0% (Zero residual glycyrrhizic acid)
Heavy Metals: < 10 ppm
Recommended Usage: 0.05% – 0.2% (Standard Skincare) / Up to 0.5% (Intensive SOS Rescue Serums)
pH Range Stability: Exceptionally stable between 4.0 – 7.0
Processing Guidelines: Pre-dissolve in a polyol (such as Propanediol) or add directly to the oil phase before emulsification.
Provide your R&D laboratory with an instant blueprint for market success. Our Liquiritigenin acts as a supreme biological neuro-calmer, protecting and amplifying the restorative efficacy of companion actives:
Liquiritigenin + Allantoin: The ultimate stinging-relief and wound-healing matrix. Combines the rapid TRPV1 neurogenic inhibition of Liquiritigenin with the water-soluble cellular regeneration of Allantoin to instantly clear micro-traumas and safely soothe post-procedure skin.
Liquiritigenin + Panthenol: A comprehensive “SOS Barrier Rescue” system. Panthenol floods the stratum corneum with deep, targeted hydration, creating a healthy, non-reactive environment that allows Liquiritigenin to efficiently “switch off” visible redness and inflammatory vasodilation without triggering irritation.
Liquiritigenin + Ceramide NP: The absolute structural and sensory defense complex. While Liquiritigenin instantly dampens acute skin reactivity and environmental stress from within, Ceramide NP safely and physically rebuilds the skin’s depleted lipid cement on the surface, ensuring a resilient, calm, and perfectly protected skin barrier.
Formulate with absolute regulatory confidence. Shaanxi Huatai Bio-Fine Chemicals Co. strictly adheres to global cosmetic safety benchmarks, ensuring our botanical derivatives pass the most stringent toxicological assessments. Our state-of-the-art manufacturing facility operates under the highest global standards, fully certified by:
ISO
COSMOS
HALAL
Every batch is supported by a comprehensive technical dossier to streamline your global compliance, supply chain transparency, and regulatory filing processes.
Stop compromising on formula stability, crude extract discoloration, and ingredient purity. Protect your consumers and elevate your product lines with the global standard in highly stable, non-sensitizing neuro-soothing actives.
Claim your High-Purity, Odorless Sample Now and upgrade your next blockbuster repair formula! Contact our technical sales team immediately to secure your free lab sample, request a customized bulk quote, and access the full Technical Dossier (TDS, MSDS, COA, and Clinical Efficacy Reports).
Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.
Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.
Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.
Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.




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