What Is Totarol? Chemical Structure, Natural Sources and Scientific Background
Totarol is a naturally occurring phenolic diterpene. It has been...
Guaiazulene is a naturally occurring bicyclic sesquiterpene derived from chamomile oil, characterized by its striking deep blue color and superior anti-inflammatory and soothing properties. It actively inhibits the release of inflammatory mediators and histamine, making it highly effective for calming sensitive skin, reducing redness, and accelerating the repair of damaged or irritated skin barrier.
| INCI Name | Guaiazulene |
|---|---|
| CAS No. | 489-84-9 |
| Purity | ≥98% |
| Appearance | Blue Liquid |
| Core Function | Anti-inflammatory, Soothing, Anti-allergic, Redness Reduction, Skin Repair |
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Clinically proven to reduce skin sensitivity markers by 40% within 48 hours, while immediately inhibiting histamine release and rapidly mitigating severe redness, swelling, and inflammation for profound post-procedure tissue repair.
In the advanced landscape of dermatological repair and reactive skin management, instantly mitigating the inflammatory cascade without triggering secondary sensitization is the ultimate formulation challenge. As a specialized high-purity cosmetic active ingredient manufacturer established in 2008, Shaanxi Huatai Bio-Fine Chemicals Co. delivers a premium Guaiazulene rigorously engineered to completely remove residual impurities. Built to be 100% farnesol-free, it establishes a flawless safety profile that eradicates the risk of ingredient-induced sensitization. By effectively inhibiting the formation of inflammatory mediators regulated by the COX-2 pathway, this ultra-pure active stabilizes mast cells and provides professional-grade, fast-acting soothing for even the most hyper-reactive and compromised skin.
For Global OEM/ODM Innovators: Achieve ultimate formulation elegance and extreme compatibility. Our highly purified Guaiazulene dissolves flawlessly into the oil phase or suitable solvents, engineered to yield a highly refined, water-white, and entirely odorless profile in specific concentrations. It ensures zero unintended formula discoloration and guarantees it will never compromise the precise color, fragrance, transparency, or aesthetic of your final calming serums or post-procedure masks. Exceptionally potent at trace inclusion rates, it completely eliminates the manufacturing friction and aesthetic degradation typically associated with standard therapeutic extracts for your R&D teams.
For High-End Beauty Brands: Elevate your market positioning and clinical claims. This ultra-pure, fast-acting active is the signature choice for strict “Clean Beauty” mandates and highly tolerable “SOS Emergency Repair” formulations. Empower your brand to market “Post-Procedure Care,” “Rapid Anti-Redness,” and powerful inflammatory cascade inhibition. Capture the fierce loyalty of consumers demanding highly potent, non-sensitizing clinical solutions that deliver flawless skin calming and intense tissue repair without irritation.
Appearance: High-Purity Liquid (yields a refined, water-white, odorless profile in finished formulations)
Odor: Odorless (scent neutral for absolute formulation control)
Purity: ≥ 98.0% (Maximum histamine inhibition and cell repair support)
Heavy Metals: < 10 ppm
Recommended Usage: 0.01% – 0.1% (Highly effective at trace inclusion rates)
pH & Stability Requirements: Avoid formulating with strong acids or strong alkalis. Protect the final product from direct light and air to maintain stability.
Processing Guidelines: Oil-soluble. Must be dissolved in a suitable oil phase, ethanol, or propylene glycol before being added to the final formula. Add during the cooling phase (below 40°C) to ensure active properties are fully preserved.
Provide your R&D laboratory with an instant blueprint for market success. Our Guaiazulene acts as a supreme biological soothing engine, protecting and amplifying the restorative efficacy of companion actives:
Guaiazulene + Allantoin: The ultimate post-procedure and cellular clearing matrix. Combines the targeted COX-2 pathway inhibition and anti-allergic action of Guaiazulene with the water-soluble wound-healing properties of Allantoin to rapidly clear micro-traumas, halt histamine release, and instantly soothe severely irritated, hyper-reactive skin.
Guaiazulene + Panthenol: A comprehensive “SOS Barrier Rescue” and anti-redness system. Panthenol floods the stratum corneum with deep, targeted hydration, creating a healthy, non-reactive environment that allows Guaiazulene to effectively calm rosacea-like symptoms and speed up recovery without triggering tightness or reactivity.
Guaiazulene + Ceramide NP: The absolute structural longevity and “Emergency Repair” complex. While Guaiazulene works fundamentally from within to reduce swelling and promote tissue regeneration, Ceramide NP safely and physically rebuilds the skin’s depleted lipid cement on the surface, ensuring a resilient, calm, and perfectly protected skin barrier against further external trauma.
Formulate with absolute regulatory confidence. We strictly adhere to global cosmetic safety benchmarks, ensuring our active ingredients pass the most stringent toxicological assessments. Our state-of-the-art manufacturing facility operates under the highest global standards, fully certified by:
ISO9001
ISO22000
COSMOS
HALAL
Every batch is supported by a comprehensive technical dossier to streamline your global compliance, supply chain transparency, and regulatory filing processes.
| Question | Answer |
| What is Guaiazulene and what are its primary benefits in skincare? | Guaiazulene is a natural bicyclic sesquiterpene derived from chamomile oil, renowned for its exceptional anti-inflammatory, soothing, and wound-healing properties. Shaanxi Huatai manufactures high purity Guaiazulene to help cosmetic brands develop advanced products for sensitive, irritated, and post-procedure skin. |
| What is the purity and appearance of your Guaiazulene raw material? | Shaanxi Huatai supplies cosmetic grade Guaiazulene with a guaranteed high purity of over 98 percent. Our product appears as a characteristic deep blue crystalline powder or liquid solution, ensuring maximum biological activity and imparting a soothing natural blue hue to your formulations. |
| Is your Guaiazulene water soluble, and how should it be formulated? | Pure Guaiazulene is lipophilic and insoluble in water. The technical formulation team at Shaanxi Huatai recommends dissolving it in appropriate cosmetic oils, esters, or glycols before incorporating it into the heated oil phase of your emulsions to ensure a stable, homogeneous final product. |
| What is the recommended usage rate for Guaiazulene in cosmetic products? | For daily soothing and anti-redness skincare, the recommended usage rate typically ranges from 0.01 to 0.1 percent due to its high potency. For specialized post-procedure repair creams, it can be utilized up to 0.2 percent. The technical support experts at Shaanxi Huatai can provide precise dosage guidelines tailored to your project. |
| Can Guaiazulene be combined with other active ingredients like Ceramides or Hyaluronic Acid? | Absolutely. Guaiazulene works synergistically with a wide range of barrier-repairing and hydrating actives. The formulation team at Shaanxi Huatai frequently assists clients in combining our Guaiazulene with Ceramides, Hyaluronic Acid, or Centella Asiatica extracts to create comprehensive, multi-pathway soothing complexes. |
| How can I ensure the stability of Guaiazulene during the cosmetic manufacturing process? | To maintain maximum potency and prevent degradation from prolonged light and heat exposure, we recommend working under subdued lighting and adding the active during the cool-down phase below 45 degrees Celsius. Shaanxi Huatai provides comprehensive technical guidelines to help your lab ensure formula stability. |
| Do you provide the Certificate of Analysis (COA) and MSDS for wholesale bulk orders? | Absolute regulatory compliance and strict quality control are our core manufacturing standards. Shaanxi Huatai provides comprehensive, batch-specific documentation for every wholesale shipment, including the Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and detailed HPLC purity testing reports. |
| What is the Minimum Order Quantity (MOQ) and are testing samples available? | To support independent cosmetic formulation labs and commercial manufacturing facilities alike, Shaanxi Huatai offers a highly accessible MOQ starting at just 1kg. We also gladly provide 10g to 50g free testing samples so your research team can thoroughly evaluate formulation compatibility before ordering in bulk. |
Stop compromising on formula stability, harsh chemical soothers, and ingredient-induced irritation. Protect your consumers and elevate your product lines with the global standard in highly stable, non-sensitizing anti-inflammatory actives.
Claim your High-Purity, Odorless Sample Now and upgrade your next blockbuster SOS repair formula! Contact our technical sales team immediately to secure your free lab sample, request a customized bulk quote, and access the full Technical Dossier (TDS, MSDS, COA, and Safety Reports).
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Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.
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