Active skincare ingredients
  • Fisetin
  • Shaanxi Huatai Bio-Fine Chemicals Co., Ltd

Fisetin

The Senolytic Breakthrough for Clearing “Zombie Cells” and Skin Rejuvenation

Fisetin is a naturally occurring flavonol and a powerful cosmetic grade active at the forefront of European anti-aging research. As a premier “Senolytic” agent, it specifically targets and helps eliminate senescent cells—often called “zombie cells”—which accumulate with age and secrete inflammatory factors that damage surrounding healthy tissue.

CAS No.

528-48-3

Source

High-Purity Botanical Extraction (Cotinus coggygria)

Appearance Color

Yellow Crystalline Powder

Key Parameter

Purity ≥ 98.0%

Solubility

Soluble in DMSO and Ethanol; Partially Water-Soluble

The Ultimate 100% Farnesol-Free Fisetin: Custom-Engineered for Extremely Sensitive Skin & Zero Sensitization

Clinically proven to reduce skin sensitivity markers by 40% within 48 hours, significantly improve skin density and elasticity, and induce targeted apoptosis in senescent “zombie” cells to restore a youthful dermal matrix.

In the vanguard of “Longevity Skincare” and biological age management, clearing metabolic waste without triggering surface irritation is the ultimate formulation challenge. As a specialized high-purity cosmetic active ingredient manufacturer, Shaanxi Huatai Bio-Fine Chemicals Co. delivers a premium Fisetin rigorously engineered via an advanced extraction process to completely remove impurities. Built to be 100% farnesol-free, it establishes a flawless safety profile that eradicates the risk of ingredient-induced sensitization. By acting as a potent senolytic, it specifically targets and clears exhausted “zombie” cells, reduces the Senescence-Associated Secretory Phenotype (SASP), and activates SIRT1 longevity pathways, reversing biological aging in even the most hyper-reactive skin.

Unlocking Unmatched Business Value

For Global OEM/ODM Innovators: Achieve ultimate formulation elegance and extreme compatibility. Our highly purified Fisetin undergoes an advanced refinement process to yield a crystal-clear, water-white, and entirely odorless profile when pre-dissolved in standard cosmetic solvents. It ensures zero formula discoloration and guarantees it will never compromise the precise color, fragrance, or aesthetic of your final product. Exceptionally stable in powder form and highly compatible within a pH range of 4.5 – 6.5, it completely eliminates manufacturing friction and stability nightmares for your R&D teams.

For High-End Beauty Brands: Elevate your market positioning and clinical claims. This ultra-pure, cutting-edge longevity active is the signature choice for strict “Clean Beauty” mandates and highly tolerable “SOS Emergency Repair” formulations. Empower your brand to market “Bio-hacking,” “Anti-Zombie Cell” technology, and deep cellular rejuvenation. Capture the fierce loyalty of consumers demanding highly potent, non-sensitizing clinical solutions that deliver superior environmental antioxidant protection and measurable improvements in dermal density without irritation.

Product Overview & Core Specifications

  • Appearance: High-purity refined powder (yields a clear, water-white, odorless profile in solution)

  • Odor: Odorless (scent neutral)

  • Purity: ≥ 98.0% (Maximum biological and senolytic activity)

  • Heavy Metals: < 10 ppm

  • Loss on Drying: ≤ 1.0%

  • Recommended Usage: 0.05% – 0.5%

  • pH Range Stability: Best maintained within a pH range of 4.5 – 6.5

  • Processing Guidelines: Pre-dissolve in a suitable solvent (such as Propanediol or Ethanol) before addition to the formulation. Store in a cool, dry place away from light to maintain peak stability.

Ready-to-Use Solutions: The Golden Synergies

Provide your R&D laboratory with an instant blueprint for market success. Our Fisetin acts as a supreme biological senolytic, protecting and amplifying the restorative efficacy of companion actives:

  • Fisetin + Allantoin: The ultimate cellular cleanup and healing matrix. Combines the targeted “zombie cell” clearance and SASP inhibition of Fisetin with the water-soluble wound-healing properties of Allantoin to rapidly clear metabolic waste, instantly soothing fatigued, hyper-reactive, and photo-damaged skin.

  • Fisetin + Panthenol: A comprehensive “SOS Barrier Rescue” and revitalizing system. Panthenol floods the stratum corneum with targeted hydration and cellular energy, creating a healthy, non-reactive environment that allows Fisetin to effectively stimulate SIRT1 longevity pathways and enhance cellular defense without inflammatory interference.

  • Fisetin + Ceramide NP: The absolute structural longevity and “Age-Reversal” complex. While Fisetin restores youthful metabolic activity and clears inflammatory signals from deep within the dermal matrix, Ceramide NP safely and physically rebuilds the skin’s depleted lipid cement on the surface, ensuring a resilient, flawless, and perfectly rejuvenated skin barrier.

Uncompromising Quality Assurance

Formulate with absolute regulatory confidence. We strictly adhere to global cosmetic safety benchmarks, ensuring our active ingredients pass the most stringent toxicological assessments. Our state-of-the-art manufacturing facility operates under the highest global standards, fully certified by:

  • ISO9001

  • ISO22000

  • COSMOS

  • HALAL

Every batch is supported by a comprehensive technical dossier to streamline your global compliance, supply chain transparency, and regulatory filing processes.

Upgrade Your Next Bestseller Today

Stop compromising on formula stability, product discoloration, and ingredient purity. Protect your consumers and elevate your product lines with the global standard in highly stable, non-sensitizing cellular longevity actives.

Claim your High-Purity, Odorless Sample Now and upgrade your next blockbuster SOS repair formula! Contact our technical sales team immediately to secure your free lab sample, request a customized bulk quote, and access the full Technical Dossier (TDS, MSDS, COA, and Safety Reports).

Empower Your Skin Science: Develop Next-Generation Formulations with Our Premium Active Ingredients.

Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.

Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.

Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.

Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.

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