What Is Totarol? Chemical Structure, Natural Sources and Scientific Background
Totarol is a naturally occurring phenolic diterpene. It has been...
The Senolytic Breakthrough for Clearing “Zombie Cells” and Skin Rejuvenation
Fisetin is a naturally occurring flavonol and a powerful cosmetic grade active at the forefront of European anti-aging research. As a premier “Senolytic” agent, it specifically targets and helps eliminate senescent cells—often called “zombie cells”—which accumulate with age and secrete inflammatory factors that damage surrounding healthy tissue.
| CAS No. | 528-48-3 |
|---|---|
| Source | High-Purity Botanical Extraction (Cotinus coggygria) |
| Appearance Color | Yellow Crystalline Powder |
| Key Parameter | Purity ≥ 98.0% |
| Solubility | Soluble in DMSO and Ethanol; Partially Water-Soluble |
Source directly from manufacturer. Zero middlemen margin, guaranteed bulk competitive pricing.
Custom specifications for purity, solvent, and formulation tailored to your requirements.
Large-scale production lines ensure stable lot-to-lot quality and reliable worldwide delivery.
ISO, Halal, Kosher, and SC certified manufacturing with batch COA test reports.
Clinically proven to reduce skin sensitivity markers by 40% within 48 hours, significantly improve skin density and elasticity, and induce targeted apoptosis in senescent “zombie” cells to restore a youthful dermal matrix.
In the vanguard of “Longevity Skincare” and biological age management, clearing metabolic waste without triggering surface irritation is the ultimate formulation challenge. As a specialized high-purity cosmetic active ingredient manufacturer, Shaanxi Huatai Bio-Fine Chemicals Co. delivers a premium Fisetin rigorously engineered via an advanced extraction process to completely remove impurities. Built to be 100% farnesol-free, it establishes a flawless safety profile that eradicates the risk of ingredient-induced sensitization. By acting as a potent senolytic, it specifically targets and clears exhausted “zombie” cells, reduces the Senescence-Associated Secretory Phenotype (SASP), and activates SIRT1 longevity pathways, reversing biological aging in even the most hyper-reactive skin.
For Global OEM/ODM Innovators: Achieve ultimate formulation elegance and extreme compatibility. Our highly purified Fisetin undergoes an advanced refinement process to yield a crystal-clear, water-white, and entirely odorless profile when pre-dissolved in standard cosmetic solvents. It ensures zero formula discoloration and guarantees it will never compromise the precise color, fragrance, or aesthetic of your final product. Exceptionally stable in powder form and highly compatible within a pH range of 4.5 – 6.5, it completely eliminates manufacturing friction and stability nightmares for your R&D teams.
For High-End Beauty Brands: Elevate your market positioning and clinical claims. This ultra-pure, cutting-edge longevity active is the signature choice for strict “Clean Beauty” mandates and highly tolerable “SOS Emergency Repair” formulations. Empower your brand to market “Bio-hacking,” “Anti-Zombie Cell” technology, and deep cellular rejuvenation. Capture the fierce loyalty of consumers demanding highly potent, non-sensitizing clinical solutions that deliver superior environmental antioxidant protection and measurable improvements in dermal density without irritation.
Appearance: High-purity refined powder (yields a clear, water-white, odorless profile in solution)
Odor: Odorless (scent neutral)
Purity: ≥ 98.0% (Maximum biological and senolytic activity)
Heavy Metals: < 10 ppm
Loss on Drying: ≤ 1.0%
Recommended Usage: 0.05% – 0.5%
pH Range Stability: Best maintained within a pH range of 4.5 – 6.5
Processing Guidelines: Pre-dissolve in a suitable solvent (such as Propanediol or Ethanol) before addition to the formulation. Store in a cool, dry place away from light to maintain peak stability.
Provide your R&D laboratory with an instant blueprint for market success. Our Fisetin acts as a supreme biological senolytic, protecting and amplifying the restorative efficacy of companion actives:
Fisetin + Allantoin: The ultimate cellular cleanup and healing matrix. Combines the targeted “zombie cell” clearance and SASP inhibition of Fisetin with the water-soluble wound-healing properties of Allantoin to rapidly clear metabolic waste, instantly soothing fatigued, hyper-reactive, and photo-damaged skin.
Fisetin + Panthenol: A comprehensive “SOS Barrier Rescue” and revitalizing system. Panthenol floods the stratum corneum with targeted hydration and cellular energy, creating a healthy, non-reactive environment that allows Fisetin to effectively stimulate SIRT1 longevity pathways and enhance cellular defense without inflammatory interference.
Fisetin + Ceramide NP: The absolute structural longevity and “Age-Reversal” complex. While Fisetin restores youthful metabolic activity and clears inflammatory signals from deep within the dermal matrix, Ceramide NP safely and physically rebuilds the skin’s depleted lipid cement on the surface, ensuring a resilient, flawless, and perfectly rejuvenated skin barrier.
Formulate with absolute regulatory confidence. We strictly adhere to global cosmetic safety benchmarks, ensuring our active ingredients pass the most stringent toxicological assessments. Our state-of-the-art manufacturing facility operates under the highest global standards, fully certified by:
ISO9001
ISO22000
COSMOS
HALAL
Every batch is supported by a comprehensive technical dossier to streamline your global compliance, supply chain transparency, and regulatory filing processes.
| Question | Answer |
| What is the botanical source of your Fisetin and what purity do you supply? | Shaanxi Huatai extracts premium Fisetin primarily from the natural stems and leaves of Cotinus coggygria (Smoke Tree). We supply high purity cosmetic grade Fisetin at 98 percent, ensuring maximum biological activity for your premium formulations. |
| What are the main cosmetic and anti aging benefits of Fisetin in skincare? | Fisetin is a powerful senolytic agent and antioxidant. It helps clear senescent cells and reduces oxidative stress. Global cosmetic formulators trust the Fisetin from Shaanxi Huatai to develop cutting edge anti aging serums and intensive cellular repair creams. |
| Is your cosmetic grade Fisetin water soluble and how should it be formulated? | Pure Fisetin is naturally lipophilic and has limited water solubility. The formulation experts at Shaanxi Huatai recommend dissolving it in appropriate cosmetic glycols, ethanol, or carrier oils during the heated oil phase to easily incorporate it into your emulsion systems. |
| What is the recommended usage rate for Fisetin in anti aging skincare products? | For optimal cellular renewal and antioxidant protection, the recommended usage rate generally ranges from 0.1 to 0.5 percent depending on the product format. The technical support team at Shaanxi Huatai can assist you in optimizing the exact dosage for your specific cosmetic line. |
| Will using Fisetin change the color or odor of my final cosmetic cream? | Fisetin is a naturally yellow powder. When used at active concentrations, it may impart a pale yellow tint to your final formulation, which consumers often associate with high activity. Shaanxi Huatai utilizes advanced purification to minimize any strong odors, ensuring a premium sensory experience. |
| Do you provide the Certificate of Analysis (COA) and MSDS for wholesale bulk orders? | Absolute regulatory compliance and strict quality control are our core standards. Shaanxi Huatai provides comprehensive, batch specific documentation for every wholesale shipment, including the Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and detailed HPLC purity testing reports. |
| What is the Minimum Order Quantity (MOQ) and are testing samples available? | To support cosmetic formulation labs and commercial manufacturing facilities alike, Shaanxi Huatai offers a highly accessible MOQ starting at just 1kg. We also gladly provide 10g to 50g free testing samples so your research team can thoroughly evaluate formulation compatibility before ordering in bulk. |
| Why should I source bulk Fisetin directly from your factory in China? | Sourcing directly from a primary botanical extraction manufacturer like Shaanxi Huatai ensures you receive highly competitive factory direct pricing without middleman markups. We guarantee strict batch to batch quality control, expert technical support for formulation challenges, and rapid global shipping to keep your production on schedule. |
Stop compromising on formula stability, product discoloration, and ingredient purity. Protect your consumers and elevate your product lines with the global standard in highly stable, non-sensitizing cellular longevity actives.
Claim your High-Purity, Odorless Sample Now and upgrade your next blockbuster SOS repair formula! Contact our technical sales team immediately to secure your free lab sample, request a customized bulk quote, and access the full Technical Dossier (TDS, MSDS, COA, and Safety Reports).
Totarol is a naturally occurring phenolic diterpene. It has been...
Table of Contents 1. Tyrosinase Inhibition: Rigorous IC50 Data Analysis...
Table of Contents 1. Formulation Reality Check 2. Glabridin: Tyrosinase...
Formulators often treat Dipotassium Glycyrrhizate (DPG) as a foolproof powder...
Let us correct the scientific misconceptions up front. Many suppliers...
Formulators hate surprises. When a new batch of active ingredients...
Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.
Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.
Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.
Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.
Room 1901, Building 2, Wanda Plaza, Beilin District, Xi'an, Shaanxi.
Email: [email protected]
Phone: +86 17868678161
Copyright © 2026. Shaanxi Huatai Bio-Fine Chemical Co., Ltd. All Rights reserved.