Supplier of high-purity functional skin care ingredients

Shaanxi Huatai Bio-Fine Chemical Co., Ltd. Products

Shaanxi Huatai Bio-Fine Chemical Co., Ltd. Factory

Shaanxi Huatai Bio-Fine Chemical Co., Ltd. Exhibition

Shaanxi Huatai Bio-Fine Chemical Co., Ltd.

Glycyrrhetinic Acid

The Gold Standard Triterpenoid for Soothing and Anti-Inflammatory Applications

Glycyrrhetinic Acid, also known as Enoxolone, is the metabolite of Glycyrrhizic Acid and a key triterpenoid active ingredient in licorice. Standardized to an ultra-high purity of 98 Percent (UV) and provided as a fine white powder, it is highly valued for its exceptional anti-inflammatory, anti-allergic, and soothing properties. Its lipophilic (oil-soluble) nature makes it ideal for superior skin penetration in high-end cosmetic and dermatological formulations.

CAS No.	471-53-4
Source	Licorice Root
Appearance	Fine White Powder
Active Content (Purity)	98 Percent
Core Function	Potent Anti-Inflammatory, Anti-Allergy, Soothing, Oil-Soluble Skin Repair
Solubility	Soluble in Oil, Ethanol, and Organic Solvents (Lipophilic)

Direct Factory Supply

Source directly from manufacturer. Zero middlemen margin, guaranteed bulk competitive pricing.

Flexible OEM/ODM

Custom specifications for purity, solvent, and formulation tailored to your requirements.

Stable Supply Chain

Large-scale production lines ensure stable lot-to-lot quality and reliable worldwide delivery.

Strict QA & Certs

ISO, Halal, Kosher, and SC certified manufacturing with batch COA test reports.

1. Product Overview & Market Relevance

Our 98 Percent Glycyrrhetinic Acid is a highly concentrated, bioavailable ingredient known for its therapeutic efficacy, particularly in treating redness, irritation, and sensitivity. Its superior purity and white color make it a premium choice for formulations where clarity, colorlessness, and maximum performance are non-negotiable, such as professional-grade skincare and pharmaceutical creams.

2. Technical Highlights and Critical Parameters

2.1 Mechanism of Action

Anti-inflammatory: Modulates the inflammatory response by affecting corticosteroid metabolism, providing potent relief from various skin irritations (e.g., UV-induced erythema, contact dermatitis).
Soothing & Repair: Acts to reduce redness and support the skin’s natural repair process, making it essential in sensitive skin formulas.
Sebum Control: Shows mild regulating effects on sebum production and is beneficial in acne-prone skin care.

2.2 Standard Technical Specifications

Parameter	Specification (98 Percent UV Grade)
Purity (HPLC/UV)	>= 98 Percent
Appearance	Uniform Fine White Powder
Odor	Very Faint, Characteristic
Mesh Size	100-200 Mesh (Very Fine)
Loss on Drying	<= 1.0 Percent
Heavy Metals (as Pb)	<= 10 ppm
Arsenic (As)	<= 1 ppm
Recommended Use Rate (in formula)	0.05 Percent – 1.0 Percent (Standard)
Shelf Life	24 Months
Storage	Store tightly sealed in a cool, dark, and dry place.

3. Market Positioning and Core Advantages

Lipophilic Efficacy: As an oil-soluble triterpenoid, it penetrates deeply, ensuring the active compound reaches target skin layers effectively.
Pharmaceutical Grade: The 98 Percent purity meets the high standards required for topical drugs and advanced cosmeceuticals.
Colorless Formulation: The white powder form allows for clean, transparent, or perfectly white final products without imparting color.

4. Formulation Guidelines

Integration Phase: Must be dissolved in the oil phase or a suitable lipophilic solvent (e.g., ethanol, glycols, or carrier oils) with gentle heating (approx. 60°C) before emulsification.
pH Stability: Highly stable across typical cosmetic pH ranges (4.5 – 7.5).
Synergy: Often combined with moisturizing agents (like Ceramides) and other soothing agents (like Bisabolol) for enhanced barrier function repair.

5. Quality Assurance and Regulatory Confidence

Our quality and safety credentials include:

COSMOS (Natural and Organic Cosmetic Standard)
ISO 9001 Quality Management System
ISO 22000 Food Safety Management System
HALAL Certification
IQNET (The International Certification Network)
Technical Dossier (Certificate of Analysis – COA, Technical Data Sheet – TDS, Material Safety Data Sheet – MSDS)

6. Typical Applications

Dermatological Creams: Anti-irritant, anti-redness, and anti-allergic formulations.
Sensitive Skincare: Post-peel products, soothing serums, and sensitive eye area treatments.
Oral Hygiene: Toothpastes and mouthwashes for gum health and anti-inflammation.
Sun Care: After-sun soothing lotions and erythema reduction products.

7. Scientific Evidence Summary

Clinical Efficacy: Documented in numerous studies for its ability to significantly reduce UV-induced erythema and skin irritation.
Bioavailability: Its lipophilic nature ensures high skin absorption rates compared to the parent, water-soluble Glycyrrhizic Acid.

8. Frequently Asked Questions (FAQ)

Question	Answer
What is Glycyrrhetinic Acid and what are its primary benefits in skincare?	Glycyrrhetinic Acid is a potent pentacyclic triterpene derivative extracted from licorice root, renowned for its exceptional anti-inflammatory, soothing, and skin-conditioning properties. It effectively reduces redness, calms irritation, and accelerates skin barrier recovery. Shaanxi Huatai manufactures high purity Glycyrrhetinic Acid to help cosmetic brands develop advanced sensitive skin, soothing, and anti-redness formulations.
What is the purity and appearance of your Glycyrrhetinic Acid raw material?	Quality is our top priority at our manufacturing facility. Shaanxi Huatai supplies cosmetic grade Glycyrrhetinic Acid with a guaranteed high purity of over 98 percent. Our product appears as a fine white crystalline powder, ensuring maximum biological activity and safety for your high-end cosmetic lines.
Is your Glycyrrhetinic Acid water soluble, and how should it be formulated?	Pure Glycyrrhetinic Acid has limited solubility in water at neutral pH. The technical formulation team at Shaanxi Huatai recommends dispersing the powder and utilizing compatible cosmetic glycols, mild alkaline adjustment, or appropriate solubilizers to ensure complete incorporation into your serums, lotions, and creams.
What is the recommended usage rate for Glycyrrhetinic Acid in cosmetic products?	For daily soothing serums, anti-redness lotions, and sensitive skin care, the recommended usage rate typically ranges from 0.1 to 1.0 percent. For specialized intensive repair treatments, it can be utilized up to 2.0 percent. The technical formulation experts at Shaanxi Huatai can provide precise dosage guidelines tailored to your project.
Why is Glycyrrhetinic Acid widely favored for sensitive and reactive skin formulations?	Glycyrrhetinic Acid mimics natural cortisol-like soothing action to effectively downregulate inflammatory mediators without the adverse side effects of steroids, making it ideal for compromised skin. Shaanxi Huatai provides high purity active ingredients ideal for crafting safe, highly effective products for sensitive skin.
Can Glycyrrhetinic Acid be combined with other active ingredients like Ceramides, Niacinamide, or Panthenol?	Absolutely. Glycyrrhetinic Acid works synergistically with a wide range of barrier-restoring and calming actives. The formulation team at Shaanxi Huatai frequently assists clients in combining our Glycyrrhetinic Acid with Ceramides, Niacinamide, or Panthenol to create comprehensive, multi-pathway soothing and barrier-repair complexes.
Do you provide the Certificate of Analysis (COA) and MSDS for wholesale bulk orders?	Absolute regulatory compliance and strict quality control are our core manufacturing standards. Shaanxi Huatai provides comprehensive, batch-specific documentation for every wholesale shipment, including the Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and detailed HPLC purity testing reports.
What is the Minimum Order Quantity (MOQ) and are testing samples available?	To support independent cosmetic formulation labs and commercial manufacturing facilities alike, Shaanxi Huatai offers a highly accessible MOQ starting at just 1kg. We also gladly provide 10g to 50g free testing samples so your research team can thoroughly evaluate formulation compatibility before ordering in bulk.

Source our 98 Percent Purity Glycyrrhetinic Acid, the key to advanced anti-inflammatory and soothing formulations.

🔒 Get Your Technical Dossier: Access TDS, MSDS, COA, and Clinical Efficacy Reports.
🔬 Apply for a Free Sample: Test the superior soothing and anti-irritant power of Glycyrrhetinic Acid today.
📞 Get a Customized Quote: Discuss bulk orders and high-purity specifications.

Empower Your Skin Science: Develop Next-Generation Formulations with Our Premium Active Ingredients.

Why choose us

Huatai Bio provides a comprehensive portfolio of high-efficacy cosmetic active ingredients, empowering global brands to create next-generation skincare formulations for high-end skincare formulation needs.

Comprehensive Solutions & Innovation: Our categories cover the full spectrum of market requirements: Anti-aging & Firming, Oil-Control & Anti-acne, Anti-inflammatory & Soothing,Antioxidant Defense, Brightening,and Hydration & Barrier Repair.We offer both established classics and cutting-edge actives.

Driven by a passion for scientific excellence, our state-of-the-art R&D laboratory is dedicated to exploring the frontier of bio-active molecules. Beyond supplying ingredients, we offer end-to-end formulation consultancy and customized solution development. Our team of expert chemists works closely with your brand to overcome complex stability issues and sensory challenges, ensuring your final product stands out in a competitive global market.

Uncompromising Quality & Credibility:We ensure every batch of our Active skincare ingredients meets rigorous quality standards, including COSMOS, ISO 9001/22000, and HALAL Certification. This commitment, backed by a complete Technical Dossier, offers clinically-backed solutions and guaranteed compliance for every formulation challenge.