Stearyl Glycyrrhetinate

The “Oil-Soluble Gold” for Soothing Lipid-Based Formulations

Formulating high-end creams, sunscreens, or anhydrous products like lip balms? Huatai Bio presents Stearyl Glycyrrhetinate, a premium lipid-soluble derivative of Glycyrrhetinic Acid. Unlike water-soluble alternatives, this ingredient dissolves seamlessly in oil phases, ensuring deep penetration and potent anti-inflammatory action without crystallization. it allows you to add powerful soothing benefits to your oil-based formulas without compromising color or texture. Sourced from natural licorice and refined to 98% purity, it is the stability your brand deserves.

1. Product Overview & Key Specifications

Stearyl Glycyrrhetinate (SG) is widely used in cosmetics due to its good compatibility and high safety profile. It offers extensive functionality, including UV protection, whitening, conditioning, antipruritic, moisturizing, and antibacterial effects. Its primary strength lies in its enhanced anti-allergic and soothing function compared to its precursor, Glycyrrhetinic Acid.

2. Technical Highlights & Critical Parameters

We provide the hard data R&D teams need to ensure seamless formulation and superior performance.

2.1 Stearyl Glycyrrhetinate Core Efficacy

• Anti-Allergy and Soothing: The most notable function is its superior anti-allergic and soothing capability.
• Moisturization and Antipruritic: It helps relieve itching and maintain skin moisture levels.
• Enhanced Absorption: It has strong transdermal absorption, allowing for deeper penetration and efficacy.
• Broad Spectrum Functionality: Also provides antibacterial and auxiliary whitening effects.

2.2 Customizable Grade Options

Storage Condition: Avoid light, ventilation, dry, in a sealed space.

3. Mechanism of Action

Stearyl Glycyrrhetinate’s soothing mechanism is confirmed by advanced 3D skin model testing:

• Tissue Morphology: Based on a 3D epidermal model (EPIKUTIS), treatment with 0.05%, 0.1%, and 0.2% SG significantly improved damaged viable cells compared to the control group (NC), and showed improvement in stratum corneum thickening.
• Cytokine Suppression: SG effectively exerts its soothing function by regulating the secretion of inflammatory factors IL-1A, TNF-A, and PGE-2.

4. Core Advantages & Market USPs

4.1 Competitive Edge for Your Brand

• Superior Soothing: Proven efficacy in regulating key inflammatory cytokines (IL-1A, TNF-A, PGE-2) and improving damaged skin morphology.
• High Permeability: The ester structure allows for strong transdermal absorption, enhancing overall efficacy.
• Dual Solubility: Available in both Alcohol Soluble and Water Soluble 98% grades, providing maximum formulation flexibility.
• Multi-Functional: Covers Anti-allergy, Soothing, Moisturizing, and Antibacterial claims.

5. Formulation Guidelines

• Recommended Use Level: 0.1% – 2% for both grades.
• Dissolution Advice: Formulators can select the appropriate 98% grade (Alcohol Soluble or Water Soluble) based on the target formula base.
• Ideal Use: Core active ingredient in anti-allergy creams, anti-itch lotions, and sensitive skin repair serums.

6. Quality Assurance & Regulatory Confidence

We are committed to the highest standards of quality and regulatory compliance.

6.1 Certificate Section

Our quality and safety credentials include:

• COSMOS (Natural and Organic Cosmetic Standard)
• ISO 9001 Quality Management System
• ISO 22000 Food Safety Management System
• HALAL Certification
• IQNET (The International Certification Network)
• Technical Dossier (Certificate of Analysis – COA, Technical Data Sheet – TDS, Material Safety Data Sheet – MSDS)

7. Recommended Synergistic Combinations

• Stearyl Glycyrrhetinate + Ceramides: Enhance anti-allergy and barrier repair synergy.
• Stearyl Glycyrrhetinate + Hyaluronic Acid: Combine potent soothing with intensive, long-lasting moisturization.

8. Typical Applications & Success Stories

• Industry Validation: Widely used in professional derma-cosmetic lines targeting eczema, irritation, and sensitivity.
• Product Categories: Anti-Redness Creams, Barrier Repair Balms, Sensitive Facial Cleansers, Baby Care.

9. Scientific Evidence & Literature Support

9.1 Research Abstracts

• Soothing Efficacy – Tissue Morphology Test: In a 3D epidermal skin model (EPIKUTIS), compared to the control group (NC), samples of SG at 0.05%, 0.1%, and 0.2% concentration showed significant improvement in viable cell damage and some improvement in stratum corneum thickening.

• Soothing Efficacy – Cytokine Test: SG effectively soothes skin by regulating the secretion of inflammatory cytokines IL-1A, TNF-A, and PGE-2.

10. Stability and Safety Data Summary

• Safety Profile: Highly compatible and safe for use in cosmetics.
• Stability: Both 98% powder grades guarantee a 24-month shelf life when stored under recommended conditions.

11. Frequently Asked Questions

Q1: How does Stearyl Glycyrrhetinate differ from Dipotassium Glycyrrhizate?

A: SG is an ester derivative, giving it stronger transdermal absorption and different solubility options (Alcohol/Water Soluble) compared to DG (Dipotassium Glycyrrhizate) which is purely water-soluble.

Q2: Is the 98% grade powder water-soluble?

A: Yes, we offer a dedicated 98% white powder grade that is water-soluble, alongside an alcohol-soluble grade.

Q3: What is the recommended dosage for the highest soothing effect?

A: Experimental data shows a high efficacy at concentrations up to 0.2% on the 3D skin model, with the recommended use level being 0.1% to 2%.

Q4: What are the main benefits for damaged skin?

A: It reduces inflammatory factors (IL-1A, TNF-A, PGE-2) and helps improve the morphology of the damaged stratum corneum and viable cell layers.

Source the Advanced Soothing Ester for Premium Sensitive Skin Repair Formulas.

🔒 Get Your Technical Dossier: Access TDS, MSDS, COA and Safety Reports.

🔬 Apply for a Free Sample: Test the superior anti-allergic power of Stearyl Glycyrrhetinate today.

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