{"id":7194,"date":"2025-12-01T08:48:26","date_gmt":"2025-12-01T08:48:26","guid":{"rendered":"https:\/\/glabridinchina.com\/?p=7194"},"modified":"2026-07-15T02:41:33","modified_gmt":"2026-07-15T02:41:33","slug":"glycyrrhizin-and-glycyrrhizic-acid-for-skin-care","status":"publish","type":"post","link":"https:\/\/glabridinchina.com\/ja\/glycyrrhizin-and-glycyrrhizic-acid-for-skin-care\/","title":{"rendered":"\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u305f\u3081\u306e\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u3068\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178"},"content":{"rendered":"

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\u5316\u5b66\u306b\u3064\u3044\u3066\u6b63\u78ba\u306b\u7406\u89e3\u3057\u307e\u3057\u3087\u3046\u3002\u51e6\u65b9\u8005\u306f\u3001\u7518\u8349\u306e\u8a98\u5c0e\u4f53\u3092\u6df7\u540c\u3059\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002<\/p>

\u30b0\u30ea\u30c1\u30eb\u30ea\u30b8\u30f3\u306f\u5929\u7136\u306e\u30b5\u30dd\u30cb\u30f3\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u7518\u8349\uff08Glycyrrhiza glabra\uff09\u306e\u6839\u306b\u542b\u307e\u308c\u308b\u4e3b\u8981\u306a\u7518\u5473\u5316\u5408\u7269\u3067\u3059\u3002\u305d\u308c\u3092\u62bd\u51fa\u3057\u7cbe\u88fd\u3059\u308b\u3068\u3001\u5f37\u529b\u306a\u751f\u7406\u6d3b\u6027\u7269\u8cea\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>

\u30b0\u30ea\u30c1\u30eb\u30ea\u30b8\u30f3\u3092\u52a0\u6c34\u5206\u89e3\u3059\u308b\u3068\u3001\u7cd6\u9396\u304c\u9664\u53bb\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u308a\u3001\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\uff08\u30b0\u30ea\u30c1\u30eb\u30ea\u30b8\u30f3\u9178\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>

\u306a\u305c\u3053\u308c\u304c\u91cd\u8981\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u308c\u306f\u3001\u305d\u308c\u3089\u304c\u76ae\u819a\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306b\u76f4\u63a5\u50cd\u304d\u304b\u3051\u308b\u304b\u3089\u3067\u3059\u3002\u305d\u308c\u3089\u306f\u3001\u9589\u585e\u6027\u4fdd\u6e7f\u5264\u306e\u3088\u3046\u306b\u8868\u9762\u306b\u7559\u307e\u308b\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u3089\u306f\u8868\u76ae\u306b\u6d78\u900f\u3057\u307e\u3059\u3002\u305d\u308c\u3089\u306f\u300111-\u30d9\u30fc\u30bf\u30d2\u30c9\u30ed\u30ad\u30b7\u30b9\u30c6\u30ed\u30a4\u30c9\u30c7\u30d2\u30c9\u30ed\u30b2\u30ca\u30fc\u30bc\u3068\u547c\u3070\u308c\u308b\u9175\u7d20\u3092\u30d6\u30ed\u30c3\u30af\u3057\u307e\u3059\u3002\u3053\u306e\u7279\u5b9a\u306e\u9175\u7d20\u306f\u3001\u901a\u5e38\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u3092\u7834\u58ca\u3057\u307e\u3059\u3002\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306f\u3001\u76ae\u819a\u306b\u7d44\u307f\u8fbc\u307e\u308c\u305f\u6d88\u706b\u5668\u3067\u3059\u3002\u9175\u7d20\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u306f\u5929\u7136\u306e\u6d88\u706b\u5668\u3092\u3088\u308a\u9577\u304f\u6a5f\u80fd\u3055\u305b\u307e\u3059\u3002\u5c40\u6240\u7684\u306a\u533b\u85ac\u54c1\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u4f7f\u7528\u305b\u305a\u306b\u3001\u6df1\u3044\u6297\u708e\u75c7\u52b9\u679c\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>

\u4ed5\u69d8\u306e\u5185\u8a33\uff1a\u6709\u52b9\u6210\u5206\u3092\u77e5\u308b<\/p>

\u4e73\u6db2\u306b\u4f55\u3092\u5165\u308c\u3066\u3044\u308b\u306e\u304b\u3092\u6b63\u78ba\u306b\u77e5\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u4e16\u754c\u306e\u5316\u7ca7\u54c1\u30d6\u30e9\u30f3\u30c9\u5411\u3051\u306b\u9ad8\u7d14\u5ea6\u30b0\u30ec\u30fc\u30c9\u3092\u88fd\u9020\u3057\u3066\u3044\u307e\u3059\u3002\u5b89\u4fa1\u3067\u4f4e\u7d14\u5ea6\u306e\u30b0\u30ec\u30fc\u30c9\u3092\u8cfc\u5165\u3059\u308b\u3068\u3001\u91cd\u91d1\u5c5e\u3084\u4e0d\u5b89\u5b9a\u306a\u690d\u7269\u30ef\u30c3\u30af\u30b9\u3092\u51e6\u65b9\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u30af\u30ea\u30fc\u30e0\u306f3\u304b\u6708\u5f8c\u306b\u5909\u8272\u3057\u3001\u3072\u3069\u3044\u81ed\u3044\u304c\u3059\u308b\u3067\u3057\u3087\u3046\u3002<\/p>

\u4ee5\u4e0b\u306f\u3001\u9ad8\u7d14\u5ea6\u5316\u7ca7\u54c1\u30d0\u30c3\u30c1\u3092\u30ea\u30ea\u30fc\u30b9\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3059\u308b\u6a19\u6e96\u7684\u306a\u4ed5\u69d8\u30c7\u30fc\u30bf\u3067\u3059\u3002<\/p>

\u30d1\u30e9\u30e1\u30fc\u30bf<\/strong><\/td>\u4ed5\u69d8\u30d9\u30f3\u30c1\u30de\u30fc\u30af<\/strong><\/td>\u8a66\u9a13\u65b9\u6cd5<\/strong><\/td><\/tr><\/thead>
\u5916\u89b3<\/td>\u767d\u8272\u304b\u3089\u6de1\u9ec4\u8272\u306e\u7d50\u6676\u6027\u7c89\u672b<\/td>\u76ee\u8996\u691c\u67fb<\/td><\/tr>
\u6d3b\u6027\u7d14\u5ea6<\/td>\u2265 98.0%<\/td>HPLC<\/td><\/tr>
CAS\u756a\u53f7<\/td>1405-86-3<\/td>\u8a72\u5f53\u306a\u3057<\/td><\/tr>
\u6eb6\u89e3\u5ea6<\/td>\u71b1\u6c34\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\u3001\u30b0\u30ea\u30b3\u30fc\u30eb\u306b\u53ef\u6eb6<\/td>\u85ac\u5c40\u65b9\u6cd5<\/td><\/tr>
\u4e7e\u71e5\u6e1b\u91cf<\/td>\u2264 5.0%<\/td>\u6442\u6c0f105\u5ea6\u30012\u6642\u9593<\/td><\/tr>
\u91cd\u91d1\u5c5e\uff08Pb\uff09<\/td>\u2264 10 ppm<\/td>\u539f\u5b50\u5438\u5149<\/td><\/tr>
\u30d2\u7d20\uff08As\uff09<\/td>\u2264 2 ppm<\/td>\u539f\u5b50\u5438\u5149<\/td><\/tr><\/tbody><\/table><\/figure>

\u5b9f\u969b\u306e\u5b9f\u9a13\u30c7\u30fc\u30bf\uff1a\u6709\u52b9\u6027\u306e\u30d9\u30f3\u30c1\u30de\u30fc\u30af<\/p>

\u79c1\u305f\u3061\u306f\u5e0c\u671b\u306b\u57fa\u3065\u3044\u3066\u51e6\u65b9\u3092\u7d44\u307f\u7acb\u3066\u307e\u305b\u3093\u3002\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u3066\u51e6\u65b9\u3092\u7d44\u307f\u7acb\u3066\u307e\u3059\u3002\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u306e\u3053\u308c\u3089\u306e\u5206\u5b50\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001\u76f4\u63a5\u6bd4\u8f03\u5b9f\u9a13\u3092\u79c1\u305f\u3061\u306e\u7814\u7a76\u6240\u3067\u5b9f\u65bd\u3057\u307e\u3059\u3002<\/p>

\u30d2\u30c8\u8868\u76ae\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3092\u63a1\u53d6\u3057\u3001\u904e\u9177\u306a\u7d2b\u5916\u7dda\u306b\u3055\u3089\u3057\u3066\u708e\u75c7\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3057\u305f\u3002\u6b21\u306b\u3001\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3E2\uff08PGE2\uff09\u306e\u653e\u51fa\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002PGE2\u306f\u3001\u76ae\u819a\u306e\u8d64\u307f\u3001\u816b\u308c\u3001\u75db\u307f\u3092\u5f15\u304d\u8d77\u3053\u3059\u4e3b\u8981\u306a\u5316\u5b66\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc\u3067\u3059\u3002<\/p>

\u6cbb\u7642\u7fa4<\/strong><\/td>PGE2\u653e\u51fa\u30ec\u30d9\u30eb\uff08pg\/mL\uff09<\/strong><\/td>\u963b\u5bb3\u7387<\/strong><\/td><\/tr><\/thead>
\u672a\u51e6\u7406\uff08\u6b63\u5e38\uff09<\/td>45<\/td>\u8a72\u5f53\u306a\u3057<\/td><\/tr>
\u7d2b\u5916\u7dda\u66b4\u9732\uff08\u6709\u52b9\u6210\u5206\u306a\u3057\uff09<\/td>320<\/td>0%<\/td><\/tr>
\u7d2b\u5916\u7dda + 0.1% \u30d1\u30f3\u30c6\u30ce\u30fc\u30eb<\/td>265<\/td>17%<\/td><\/tr>
\u7d2b\u5916\u7dda + 0.1% \u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178<\/td>115<\/td>64%<\/td><\/tr>
\u7d2b\u5916\u7dda + 0.5% \u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178<\/td>68<\/td>78%<\/td><\/tr><\/tbody><\/table><\/figure>

\u6570\u5024\u3092\u898b\u3066\u304f\u3060\u3055\u3044\u3002\u30d1\u30f3\u30c6\u30ce\u30fc\u30eb\u306f\u6709\u540d\u306a\u93ae\u9759\u5264\u3067\u3059\u304c\u3001\u540c\u6fc3\u5ea6\u3067\u306f\u3001\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u306f\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u4e0a\u3067\u305d\u308c\u3092\u5287\u7684\u306b\u4e0a\u56de\u308a\u307e\u3059\u3002\u91cd\u5ea6\u306e\u8d64\u307f\u306e\u8efd\u6e1b\u304c\u8fc5\u901f\u306b\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>

\u51e6\u65b9\u306e\u73fe\u5b9f\uff1a\u30bf\u30f3\u30af\u5185\u3067\u306e\u4f5c\u696d<\/p>

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\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u306f\u3001\u72ec\u81ea\u306e\u51e6\u65b9\u7279\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u5f31\u9178\u6027\u3067\u3059\u3002\u6c34\u5206\u91cf\u306e\u591a\u3044\u7f8e\u5bb9\u6db2\u306b\u4f7f\u7528\u3059\u308b\u3068\u3001\u30d0\u30c3\u30c1\u306epH\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5f93\u6765\u306e\u30ab\u30eb\u30dc\u30de\u30fc\u306b\u983c\u3063\u3066\u7f8e\u5bb9\u6db2\u3092\u5897\u7c98\u3055\u305b\u3066\u3044\u308b\u5834\u5408\u3001\u3053\u306e\u7a81\u7136\u306epH\u4f4e\u4e0b\u306f\u30dd\u30ea\u30de\u30fc\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u7834\u58ca\u3057\u307e\u3059\u3002\u6fc3\u539a\u306a\u7f8e\u5bb9\u6db2\u306f\u77ac\u6642\u306b\u6c34\u72b6\u306b\u306a\u308a\u307e\u3059\u3002<\/p>

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\u5206\u6790\u8a3c\u660e\u66f8\uff08COA\uff09\u3092\u8aad\u3080<\/p>

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\u5b9f\u4e16\u754c\u306e\u5fdc\u7528\u4e8b\u4f8b<\/p>

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\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u304a\u3088\u3073\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u306f\u3001\u512a\u308c\u305f\u5b89\u5168\u6027\u306e\u5b9f\u7e3e\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u5316\u7ca7\u54c1\u6210\u5206\u5be9\u67fb\u5c02\u9580\u5bb6\u30d1\u30cd\u30eb\uff08CIR\uff09\u306f\u3001\u3053\u308c\u3089\u306e\u5316\u5408\u7269\u3092\u5e83\u7bc4\u306b\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u5f7c\u3089\u306f\u3001\u73fe\u5728\u306e\u5316\u7ca7\u54c1\u7528\u9014\u306b\u304a\u3044\u3066\u5b89\u5168\u3067\u3042\u308b\u3068\u5224\u65ad\u3057\u307e\u3057\u305f\u3002\u5149\u7dda\u904e\u654f\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u305b\u3093\u3002\u76ae\u819a\u3092\u8584\u304f\u3057\u307e\u305b\u3093\u3002\u3053\u306e\u30b0\u30ed\u30fc\u30d0\u30eb\u306a\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u306b\u3088\u308a\u3001\u898f\u5236\u4e0a\u306e\u61f8\u5ff5\u306a\u304f\u3001\u5358\u4e00\u306eSKU\u3092\u51e6\u65b9\u3057\u3001\u30a2\u30b8\u30a2\u3001\u30e8\u30fc\u30ed\u30c3\u30d1\u3001\u5317\u7c73\u3067\u8ca9\u58f2\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>

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\u76f8<\/strong><\/td>INCI\u540d<\/strong><\/td>\u30d1\u30fc\u30bb\u30f3\u30c6\u30fc\u30b8 (%)<\/strong><\/td>\u95a2\u6570<\/strong><\/td><\/tr><\/thead>
A<\/td>Water (Aqua)<\/td>Q.S. 100\u307e\u3067<\/td>\u6eb6\u5a92<\/td><\/tr>
A<\/td>\u30b0\u30ea\u30bb\u30ea\u30f3<\/td>3.0<\/td>\u4fdd\u6e7f\u5264<\/td><\/tr>
A<\/td>\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\uff08\u4f4e\u5206\u5b50\u91cf\uff09<\/td>0.2<\/td>\u30c7\u30a3\u30fc\u30d7\u30cf\u30a4\u30c9\u30ec\u30fc\u30b7\u30e7\u30f3<\/td><\/tr>
B<\/td>\u30d7\u30ed\u30d1\u30f3\u30b8\u30aa\u30fc\u30eb<\/td>5.0<\/td>\u6d78\u900f\u4fc3\u9032\u5264<\/td><\/tr>
B<\/td>\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178 (98%)<\/td>0.15<\/td>\u30a2\u30af\u30c6\u30a3\u30d6\u30fb\u30b9\u30fc\u30b8\u30f3\u30b0\u30fb\u30a8\u30f3\u30b8\u30f3<\/td><\/tr>
B<\/td>\u30a2\u30e9\u30f3\u30c8\u30a4\u30f3<\/td>0.2<\/td>\u76ae\u819a\u4fdd\u8b77\u5264<\/td><\/tr>
C<\/td>\u30bb\u30e9\u30df\u30c9NP<\/td>0.1<\/td>\u30d0\u30ea\u30a2\u8102\u8cea<\/td><\/tr>
D<\/td>\u30d2\u30c9\u30ed\u30ad\u30b7\u30a8\u30c1\u30eb\u30bb\u30eb\u30ed\u30fc\u30b9<\/td>0.4<\/td>\u30ec\u30aa\u30ed\u30b8\u30fc\u30fb\u30e2\u30c7\u30a3\u30d5\u30a1\u30a4\u30e4\u30fc<\/td><\/tr>
E<\/td>\u30d5\u30a7\u30ce\u30ad\u30b7\u30a8\u30bf\u30ce\u30fc\u30eb\u3001\u30a8\u30c1\u30eb\u30d8\u30ad\u30b7\u30eb\u30b0\u30ea\u30bb\u30ea\u30f3<\/td>0.8<\/td>\u5e83\u57df\u30b9\u30da\u30af\u30c8\u30eb\u9632\u8150\u5264<\/td><\/tr><\/tbody><\/table><\/figure>

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\u5f15\u7528\u3055\u308c\u305f\u516c\u958b\u6587\u732e\u304a\u3088\u3073\u6a29\u5a01\u3042\u308b\u53c2\u8003\u6587\u732e\uff1a<\/p>

  1. \u5316\u7ca7\u54c1\u6210\u5206\u30ec\u30d3\u30e5\u30fc\uff08CIR\uff09\u5c02\u9580\u5bb6\u30d1\u30cd\u30eb\u3002\uff082007\u5e74\uff09\u3002\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u3001\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u30ab\u30ea\u30a6\u30e0\u3001\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u30b8\u30ab\u30ea\u30a6\u30e0\u3001\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u30a2\u30f3\u30e2\u30cb\u30a6\u30e0\u3001\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u306e\u5b89\u5168\u6027\u8a55\u4fa1\u306b\u95a2\u3059\u308b\u6700\u7d42\u5831\u544a\u66f8\u3002International Journal of Toxicology\u3002<\/li>\n\n
  2. Saeedi, M.\u3089\u3002\uff082003\u5e74\uff09\u3002\u7518\u8349\u30b2\u30eb\u306b\u3088\u308b\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u6cbb\u7642\u3002Journal of Dermatological Treatment, 14(3), 153-157\u3002<\/li>\n\n
  3. Asl, M. N. & Hosseinzadeh, H. (2008)\u3002Glycyrrhiza sp. \u304a\u3088\u3073\u305d\u306e\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u306e\u85ac\u7406\u5b66\u7684\u52b9\u679c\u306e\u30ec\u30d3\u30e5\u30fc\u3002Phytotherapy Research, 22(6), 709-724\u3002<\/li>\n\n
  4. \u6b27\u5dde\u59d4\u54e1\u4f1a\uff08CosIng\uff09\u5316\u7ca7\u54c1\u6210\u5206\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9 \u2013 \u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u306e\u898f\u5236\u72b6\u6cc1\u3002<\/li><\/ol>","protected":false},"excerpt":{"rendered":"

    I see formulators make the same mistake every week. They want to calm irritated skin. They buy a drum of generic brown licorice extract. They…<\/p>","protected":false},"author":8,"featured_media":6422,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60],"tags":[],"class_list":["post-7194","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-product-news"],"yoast_head":"\nGlycyrrhizin and Glycyrrhizic Acid for Skin Care - Shaanxi Huatai Bio-Fine Chemical Co., Ltd.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/glabridinchina.com\/ja\/glycyrrhizine-et-acide-glycyrrhizique-pour-les-soins-de-la-peau\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Glycyrrhizin and Glycyrrhizic Acid for Skin Care\" \/>\n<meta property=\"og:description\" content=\"I see formulators make the same mistake every week. 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