{"id":15989,"date":"2026-09-15T08:35:20","date_gmt":"2026-09-15T08:35:20","guid":{"rendered":"https:\/\/glabridinchina.com\/?p=15989"},"modified":"2026-09-15T08:35:21","modified_gmt":"2026-09-15T08:35:21","slug":"licochalcone-a-for-skin-corrected-formulation-specs-ic50-benchmarks-and-clinical-realities","status":"publish","type":"post","link":"https:\/\/glabridinchina.com\/ja\/licochalcone-a-for-skin-corrected-formulation-specs-ic50-benchmarks-and-clinical-realities\/","title":{"rendered":"\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\uff08\u76ae\u819a\u7528\uff09\uff1a\u51e6\u65b9\u4ed5\u69d8\u3001IC50\u30d9\u30f3\u30c1\u30de\u30fc\u30af\u3001\u304a\u3088\u3073\u81e8\u5e8a\u7684\u73fe\u5b9f\u306e\u4fee\u6b63"},"content":{"rendered":"<div style=\"max-width: 100%; font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif; line-height: 1.8; color: #333333; padding: 15px; background-color: #ffffff;\">\n    <div style=\"background-color: #f8fafc; padding: 20px; border-radius: 8px; margin-bottom: 35px; border: 1px solid #e2e8f0;\">\n        <h2 style=\"color: #2d3748; font-size: 18px; margin-top: 0; margin-bottom: 15px; text-transform: uppercase;\">\u76ee\u6b21<\/h2>\n        <ul style=\"list-style-type: none; padding-left: 0; margin: 0;\">\n            <li style=\"margin-bottom: 10px;\"><a href=\"#section1\" style=\"color: #3182ce; text-decoration: none; font-weight: 500;\">\u85ac\u7269\u52d5\u614b\u5b66\uff1a\u76ae\u819a\u3078\u306e\u73fe\u5b9f\u7684\u306a\u691c\u8a3c<\/a><\/li>\n            <li style=\"margin-bottom: 10px;\"><a href=\"#section2\" style=\"color: #3182ce; text-decoration: none; font-weight: 500;\">\u7269\u7406\u5316\u5b66\u7684\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3068\u69cb\u9020\u7684\u53b3\u5bc6\u6027<\/a><\/li>\n            <li style=\"margin-bottom: 10px;\"><a href=\"#section3\" style=\"color: #3182ce; text-decoration: none; font-weight: 500;\">\u5b9f\u8a3c\u7684\u6709\u52b9\u6027\uff1aIC50\u3001MIC\u3001\u304a\u3088\u3073ROS\u306e\u57fa\u6e96\u5024<\/a><\/li>\n            <li style=\"margin-bottom: 10px;\"><a href=\"#section4\" style=\"color: #3182ce; text-decoration: none; font-weight: 500;\">\u88fd\u5264\u30a2\u30fc\u30ad\u30c6\u30af\u30c1\u30e3\uff1a\u6eb6\u5a92\u3068\u6295\u4e0e\u91cf\u88dc\u6b63<\/a><\/li>\n            <li style=\"margin-bottom: 10px;\"><a href=\"#section5\" style=\"color: #3182ce; text-decoration: none; font-weight: 500;\">\u54c1\u8cea\u6307\u6a19\uff1a\u4ed5\u69d8\u30de\u30c3\u30d4\u30f3\u30b0\u3068COA\u30c7\u30fc\u30bf<\/a><\/li>\n            <li style=\"margin-bottom: 10px;\"><a href=\"#section6\" style=\"color: #3182ce; text-decoration: none; font-weight: 500;\">\u30b0\u30ed\u30fc\u30d0\u30eb\u898f\u5236\u9075\u5b88<\/a><\/li>\n            <li style=\"margin-bottom: 10px;\"><a href=\"#section7\" style=\"color: #3182ce; text-decoration: none; font-weight: 500;\">B2B\u30bd\u30fc\u30b7\u30f3\u30b0FAQ\uff1a\u88fd\u5264\u62c5\u5f53\u8005\u304b\u3089\u306e8\u3064\u306e\u91cd\u8981\u306a\u8cea\u554f<\/a><\/li>\n            <li><a href=\"#section8\" style=\"color: #3182ce; text-decoration: none; font-weight: 500;\">\u691c\u8a3c\u6e08\u307f\u79d1\u5b66\u7684\u53c2\u8003\u6587\u732e<\/a><\/li>\n        <\/ul>\n    <\/div>\n\n    <!-- \u6b63\u6587\u5185\u5bb9 -->\n    <h3 id=\"section1\" style=\"color: #2b6cb0; font-size: 22px; border-left: 4px solid #3182ce; padding-left: 10px; margin-top: 40px;\">\n        \u85ac\u7269\u52d5\u614b\u5b66\uff1a\u76ae\u819a\u3078\u306e\u73fe\u5b9f\u7684\u306a\u691c\u8a3c\n    <\/h3>\n    <p>\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\uff08\u30ea\u30b3-A\uff09\u3092\u5358\u306a\u308b\u4e00\u822c\u7684\u306a\u93ae\u9759\u690d\u7269\u6210\u5206\u3060\u3068\u8003\u3048\u3066\u3044\u307e\u305b\u3093\u304b\uff1f <span style=\"color: #e53e3e; font-weight: bold;\">\u305d\u3046\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/span> \u3053\u308c\u306f\u3001\u304b\u3089\u5358\u96e2\u3055\u308c\u305f\u975e\u5e38\u306b\u6d3b\u6027\u306e\u9ad8\u3044\u30ec\u30c8\u30ed\u30ab\u30eb\u30b3\u30f3\u3067\u3059 <em>\u30ab\u30f3\u30be\u30a6<\/em>\u3002\u76ae\u819a\u8868\u9762\u306e\u9589\u585e\u306b\u4f9d\u5b58\u3057\u307e\u305b\u3093\u3002\u751f\u5316\u5b66\u7684\u5909\u5316\u3092\u5f37\u5236\u3057\u307e\u3059\u3002<\/p>\n    <p>\u8102\u8cea\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306b\u6025\u901f\u306b\u6d78\u900f\u3057\u307e\u3059\u3002\u5185\u90e8\u306b\u5165\u308b\u3068\u3001\u30a2\u30e9\u30ad\u30c9\u30f3\u9178\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\u3002COX-2\u304a\u3088\u3073iNOS\u306e\u767a\u73fe\u3092\u9078\u629e\u7684\u306b\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3057\u307e\u3059\u3002\u3053\u308c\u306fNF-\u03baB\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30e2\u30b8\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u4ecb\u3057\u3066\u8d77\u3053\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7121\u6761\u4ef6\u306b\u5b89\u5168\u3067\u3057\u3087\u3046\u304b\uff1f\u3044\u3044\u3048\u3002 <span style=\"color: #d69e2e; font-weight: bold;\">\u672a\u898f\u5236\u306e\u7528\u91cf\u306f\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u767a\u3057\u307e\u3059\u3002<\/span> \u6709\u52b9\u6027\u306f\u3001\u7d30\u80de\u6bd2\u6027\u672a\u6e80\u306e\u6fc3\u5ea6\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002\u6b63\u78ba\u306a\u30de\u30a4\u30af\u30ed\u30e2\u30eb\u6fc3\u5ea6\u3067\u3001\u7d30\u80de\u5185\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u8272\u7d20\u6c88\u7740\u904e\u5270\u306e\u5236\u5fa1\u306e\u305f\u3081\u306b\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u4e00\u822c\u7684\u306a\u4e3b\u5f35\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6a19\u7684\u5316\u3055\u308c\u305f\u7d4c\u8def\u4ecb\u5165\u306e\u307f\u3067\u3059\u3002<\/p>\n\n    <h3 id=\"section2\" style=\"color: #2b6cb0; font-size: 22px; border-left: 4px solid #3182ce; padding-left: 10px; margin-top: 40px;\">\n        \u7269\u7406\u5316\u5b66\u7684\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3068\u69cb\u9020\u7684\u53b3\u5bc6\u6027\n    <\/h3>\n    <p>\u88fd\u5264\u62c5\u5f53\u8005\u306f\u6eb6\u89e3\u5ea6\u30d1\u30e9\u30e1\u30fc\u30bf\u3092\u63a8\u6e2c\u3067\u304d\u307e\u305b\u3093\u3002\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u306f\u6271\u3044\u306b\u304f\u3044\u5206\u5b50\u3067\u3059\u3002\u7d30\u304b\u3044\u9ec4\u8272\u306e\u7c89\u672b\u3068\u3057\u3066\u5b58\u5728\u3057\u307e\u3059\u3002\u975e\u5e38\u306b\u89aa\u6cb9\u6027\u3067\u3059\u3002\u6c34\u3078\u306e\u6eb6\u89e3\u5ea6\u306f\u5b9f\u8cea\u7684\u306b\u30bc\u30ed\u3067\u3059\u3002\u6eb6\u5a92\u306e\u597d\u307f\u3092\u5c0a\u91cd\u3057\u306a\u3044\u3068\u3001\u3059\u3050\u306b\u7d50\u6676\u5316\u3057\u307e\u3059\u3002<\/p>\n    \n    <div style=\"overflow-x: auto;\">\n        <table style=\"width: 100%; max-width: 100%; border-collapse: collapse; margin: 20px 0; font-size: 15px; border: 1px solid #e2e8f0;\">\n            <thead>\n                <tr style=\"background-color: #edf2f7; border-bottom: 2px solid #cbd5e0;\">\n                    <th style=\"padding: 12px 15px; text-align: left; color: #2d3748; font-weight: 600;\">\u30d1\u30e9\u30e1\u30fc\u30bf<\/th>\n                    <th style=\"padding: 12px 15px; text-align: left; color: #2d3748; font-weight: 600;\">\u4ed5\u69d8\/\u691c\u8a3c\u6e08\u307f\u30c7\u30fc\u30bf<\/th>\n                <\/tr>\n            <\/thead>\n            <tbody>\n                <tr style=\"border-bottom: 1px solid #e2e8f0;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u5316\u5b66\u540d<\/td>\n                    <td style=\"padding: 12px 15px;\">(2E)-3-[5-(1,1-\u30b8\u30e1\u30c1\u30eb-2-\u30d7\u30ed\u30da\u30f3-1-\u30a4\u30eb)-4-\u30d2\u30c9\u30ed\u30ad\u30b7-2-\u30e1\u30c8\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb]-1-(4-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb)-2-\u30d7\u30ed\u30da\u30f3-1-\u30aa\u30f3<\/td>\n                <\/tr>\n                <tr style=\"border-bottom: 1px solid #e2e8f0; background-color: #f7fafc;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">CAS\u756a\u53f7<\/td>\n                    <td style=\"padding: 12px 15px;\">58749-22-7<\/td>\n                <\/tr>\n                <tr style=\"border-bottom: 1px solid #e2e8f0;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u5206\u5b50\u5f0f<\/td>\n                    <td style=\"padding: 12px 15px;\">C21H22O4<\/td>\n                <\/tr>\n                <tr style=\"border-bottom: 1px solid #e2e8f0; background-color: #f7fafc;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u5206\u5b50\u91cf<\/td>\n                    <td style=\"padding: 12px 15px;\">4 g\/mol<\/td>\n                <\/tr>\n                <tr style=\"border-bottom: 1px solid #e2e8f0;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u5916\u89b3<\/td>\n                    <td style=\"padding: 12px 15px;\">\u7d30\u304b\u3044\u9ec4\u8272\u304b\u3089\u9ec4\u7dd1\u8272\u306e\u7c89\u672b<\/td>\n                <\/tr>\n                <tr style=\"border-bottom: 1px solid #e2e8f0; background-color: #f7fafc;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u6eb6\u89e3\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb<\/td>\n                    <td style=\"padding: 12px 15px;\"><span style=\"color: #e53e3e; font-weight: 600;\">\u6c34\uff1a\u4e0d\u6eb6<\/span> | DMF\uff1a25 mg\/mL | DMSO\uff1a15 mg\/mL | \u30a8\u30bf\u30ce\u30fc\u30eb\uff1a20 mg\/mL<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u71b1\u5b89\u5b9a\u6027<\/td>\n                    <td style=\"padding: 12px 15px;\">80\u00b0C\u4ee5\u4e0a\u3067\u9577\u6642\u9593\u66b4\u9732\u3059\u308b\u3068\u5206\u89e3\u304c\u59cb\u307e\u308a\u307e\u3059<\/td>\n                <\/tr>\n            <\/tbody>\n        <\/table>\n    <\/div>\n\n    <h3 id=\"section3\" style=\"color: #2b6cb0; font-size: 22px; border-left: 4px solid #3182ce; padding-left: 10px; margin-top: 40px;\">\n        \u5b9f\u8a3c\u7684\u6709\u52b9\u6027\uff1aIC50\u3001MIC\u3001\u304a\u3088\u3073ROS\u306e\u57fa\u6e96\u5024\n    <\/h3>\n    <p>\u30de\u30fc\u30b1\u30c6\u30a3\u30f3\u30b0\u306e\u8a87\u5927\u5e83\u544a\u3092\u4fe1\u3058\u308b\u306e\u3092\u3084\u3081\u307e\u3057\u3087\u3046\u3002\u30c7\u30fc\u30bf\u3092\u898b\u3066\u304f\u3060\u3055\u3044\u3002\u30ea\u30b3-A\u306f\u660e\u78ba\u306a\u9759\u83cc\u4f5c\u7528\u3092\u793a\u3057\u307e\u3059\u3002\u6a19\u7684\u3068\u3057\u307e\u3059 <em>\u30a2\u30af\u30cd\u83cc<\/em> \u305d\u3057\u3066 <em>\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc<\/em>\u3002\u6297\u751f\u7269\u8cea\u8010\u6027\u3092\u8a98\u767a\u3059\u308b\u3053\u3068\u306a\u304f\u3001\u7d30\u83cc\u819c\u3092\u4e0d\u5b89\u5b9a\u5316\u3057\u307e\u3059\u3002<\/p>\n    \n    <div style=\"overflow-x: auto;\">\n        <table style=\"width: 100%; max-width: 100%; border-collapse: collapse; margin: 20px 0; font-size: 15px; border: 1px solid #e2e8f0;\">\n            <thead>\n                <tr style=\"background-color: #edf2f7; border-bottom: 2px solid #cbd5e0;\">\n                    <th style=\"padding: 12px 15px; text-align: left; color: #2d3748; font-weight: 600;\">\u85ac\u7406\u5b66\u7684\u6a19\u7684<\/th>\n                    <th style=\"padding: 12px 15px; text-align: left; color: #2d3748; font-weight: 600;\">\u6307\u6a19\/\u5024<\/th>\n                    <th style=\"padding: 12px 15px; text-align: left; color: #2d3748; font-weight: 600;\">\u7d4c\u8def\/\u30e1\u30ab\u30cb\u30ba\u30e0<\/th>\n                <\/tr>\n            <\/thead>\n            <tbody>\n                <tr style=\"border-bottom: 1px solid #e2e8f0;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u7d30\u83cc\u963b\u5bb3\uff08C. acnes\uff09<\/td>\n                    <td style=\"padding: 12px 15px;\"><span style=\"color: #2b6cb0; font-weight: bold;\">MIC\uff1a4.0 \u2013 16.0 \u03bcg\/mL<\/span><\/td>\n                    <td style=\"padding: 12px 15px;\">\u7d30\u80de\u819c\u8cab\u901a\u6392\u51fa\u30dd\u30f3\u30d7\u306e\u7834\u58ca\u3002<\/td>\n                <\/tr>\n                <tr style=\"border-bottom: 1px solid #e2e8f0; background-color: #f7fafc;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u7d30\u80de\u751f\u5b58\u7387\u306e\u95be\u5024<\/td>\n                    <td style=\"padding: 12px 15px;\"><span style=\"color: #e53e3e; font-weight: bold;\">\u5b89\u5168 &lt; 20 \u03bcM<\/span><\/td>\n                    <td style=\"padding: 12px 15px;\">\u3088\u308a\u9ad8\u3044\u6fc3\u5ea6\u306f\u30ab\u30b9\u30d1\u30fc\u30bc\u4f9d\u5b58\u6027\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u767a\u3057\u307e\u3059\u3002<\/td>\n                <\/tr>\n                <tr style=\"border-bottom: 1px solid #e2e8f0;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">ROS\u6e1b\u8870<\/td>\n                    <td style=\"padding: 12px 15px;\">5 \u03bcM\u3067\u6709\u610f\u306a\u6e1b\u5c11<\/td>\n                    <td style=\"padding: 12px 15px;\">\u76f4\u63a5\u7684\u306a\u30e9\u30b8\u30ab\u30eb\u30b9\u30ab\u30d9\u30f3\u30b8\u30f3\u30b0\u3002\u7d30\u80de\u306e\u5b8c\u5168\u6027\u3092\u7dad\u6301\u3057\u307e\u3059\u3002<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3<\/td>\n                    <td style=\"padding: 12px 15px;\">IC50\uff1a\u7d0446.6 \u03bcM<\/td>\n                    <td style=\"padding: 12px 15px;\">\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u9175\u7d20\u306e\u975e\u7af6\u5408\u7684\u963b\u5bb3\u3002<\/td>\n                <\/tr>\n            <\/tbody>\n        <\/table>\n    <\/div>\n\n    <h3 id=\"section4\" style=\"color: #2b6cb0; font-size: 22px; border-left: 4px solid #3182ce; padding-left: 10px; margin-top: 40px;\">\n        \u88fd\u5264\u30a2\u30fc\u30ad\u30c6\u30af\u30c1\u30e3\uff1a\u6eb6\u5a92\u3068\u6295\u4e0e\u91cf\u88dc\u6b63\n    <\/h3>\n    <p>\u3053\u3053\u3067\u307b\u3068\u3093\u3069\u306e\u7814\u7a76\u958b\u767a\u30c1\u30fc\u30e0\u304c\u5931\u6557\u3057\u307e\u3059\u3002\u9ad8\u7d14\u5ea6\u30ea\u30b3-A\u306e\u4ee5\u524d\u8ff0\u3079\u3089\u308c\u305f2.0%\u306e\u4f7f\u7528\u7387\u306f\u3001\u58ca\u6ec5\u7684\u306a\u88fd\u5264\u30a8\u30e9\u30fc\u3067\u3059\u3002 <span style=\"color: #e53e3e; font-weight: bold;\">95%\u7d14\u7c8b\u306a\u30ea\u30b3-A\u62bd\u51fa\u7269\u306e2.0%\u306f\u3001\u91cd\u5ea6\u306e\u76ae\u819a\u523a\u6fc0\u3068\u88fd\u5264\u306e\u4e0d\u5b89\u5b9a\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/span> \u6295\u4e0e\u91cf\u306f\u62bd\u51fa\u7269\u306e\u7d14\u5ea6\u306b\u53b3\u5bc6\u306b\u30de\u30c3\u30d4\u30f3\u30b0\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n    <ul style=\"padding-left: 20px;\">\n        <li style=\"margin-bottom: 10px;\"><strong>\u88dc\u6b63\u3055\u308c\u305f\u6295\u4e0e\u91cf\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff1a<\/strong> 90-95%\u8d85\u9ad8\u7d14\u5ea6\u30b0\u30ec\u30fc\u30c9\u306e\u5834\u5408\u3001\u6a5f\u80fd\u7684\u306a\u6295\u5165\u91cf\u306f <span style=\"color: #2b6cb0; font-weight: bold;\">0.01%\u304b\u30890.05%\u3067\u3059<\/span>\u3067\u3059\u300220-40%\u6a19\u6e96\u62bd\u51fa\u7269\u306e\u5834\u5408\u3001\u6295\u5165\u91cf\u306f0.1%\u304b\u30890.5%\u306e\u7bc4\u56f2\u3067\u3059\u3002\u6c7a\u3057\u3066\u76f2\u76ee\u7684\u306b2.0%\u3067\u6295\u4e0e\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/li>\n        <li style=\"margin-bottom: 10px;\"><strong>\u53ef\u6eb6\u5316\uff1a<\/strong> \u6c34\u76f8\u3067\u4f55\u304c\u8d77\u3053\u308b\u304b\uff1f\u5373\u6642\u306e\u6c88\u6bbf\u3002PEG-400\u3001\u30d6\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u3001\u307e\u305f\u306f\u52a0\u71b1\u3055\u308c\u305f\u8102\u8cea\u76f8\u306b\u7c89\u672b\u3092\u4e8b\u524d\u306b\u6eb6\u89e3\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/li>\n        <li style=\"margin-bottom: 10px;\"><strong>\u6e29\u5ea6\u5236\u5fa1\uff1a<\/strong> \u9577\u6642\u959370\u00b0C\u4ee5\u4e0a\u306b\u52a0\u71b1\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u30ab\u30eb\u30b3\u30f3\u69cb\u9020\u306f\u71b1\u9178\u5316\u306b\u654f\u611f\u3067\u3059\u3002\u4e73\u5316\u3057\u3001\u6025\u901f\u306b\u51b7\u5374\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/li>\n        <li><strong>\u76f8\u4e57\u52b9\u679c\uff1a<\/strong> 02%\u7d14\u7c8b\u306a\u30ea\u30b3-A\u30684.0%\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3092\u7d44\u307f\u5408\u308f\u305b\u307e\u3059\u3002\u3053\u306e\u4e8c\u91cd\u7d4c\u8def\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u904e\u5270\u306a\u76ae\u8102\u5206\u6ccc\u3068\u5c40\u6240\u7684\u306a\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u4e21\u65b9\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\u3002<\/li>\n    <\/ul>\n\n    <h3 id=\"section5\" style=\"color: #2b6cb0; font-size: 22px; border-left: 4px solid #3182ce; padding-left: 10px; margin-top: 40px;\">\n        \u54c1\u8cea\u6307\u6a19\uff1a\u4ed5\u69d8\u30de\u30c3\u30d4\u30f3\u30b0\u3068COA\u30c7\u30fc\u30bf\n    <\/h3>\n    <p>\u3059\u3079\u3066\u306e\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u304c\u5316\u7ca7\u54c1\u30b0\u30ec\u30fc\u30c9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7c97\u62bd\u51fa\u7269\u306f\u3001\u91cd\u3044\u7740\u8272\u8ca0\u8377\u3068\u4e88\u6e2c\u4e0d\u53ef\u80fd\u306a\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u6b8b\u6e23\u3092\u542b\u3093\u3067\u3044\u307e\u3059\u3002\u5546\u696d\u7684\u306a\u30b9\u30b1\u30fc\u30eb\u30a2\u30c3\u30d7\u306b\u306f\u6a19\u6e96\u5316\u304c\u5fc5\u9808\u3067\u3059\u3002<\/p>\n    \n    <div style=\"overflow-x: auto;\">\n        <table style=\"width: 100%; max-width: 100%; border-collapse: collapse; margin: 20px 0; font-size: 15px; border: 1px solid #e2e8f0;\">\n            <thead>\n                <tr style=\"background-color: #edf2f7; border-bottom: 2px solid #cbd5e0;\">\n                    <th style=\"padding: 12px 15px; text-align: left; color: #2d3748; font-weight: 600;\">\u4ed5\u69d8\u30b0\u30ec\u30fc\u30c9<\/th>\n                    <th style=\"padding: 12px 15px; text-align: left; color: #2d3748; font-weight: 600;\">\u7d14\u5ea6\uff08HPLC\uff09<\/th>\n                    <th style=\"padding: 12px 15px; text-align: left; color: #2d3748; font-weight: 600;\">\u88dc\u6b63\u3055\u308c\u305f\u88fd\u5264\u9069\u7528<\/th>\n                <\/tr>\n            <\/thead>\n            <tbody>\n                <tr style=\"border-bottom: 1px solid #e2e8f0;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u6a19\u6e96\u62bd\u51fa\u7269<\/td>\n                    <td style=\"padding: 12px 15px;\">\u2265 20.0%<\/td>\n                    <td style=\"padding: 12px 15px;\">\u8272\u4ed8\u304d\u30e2\u30a4\u30b9\u30c1\u30e3\u30e9\u30a4\u30b6\u30fc\u3001\u57fa\u672c\u7684\u306a\u30d0\u30ea\u30a2\u30af\u30ea\u30fc\u30e0\u3002<\/td>\n                <\/tr>\n                <tr style=\"border-bottom: 1px solid #e2e8f0; background-color: #f7fafc;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u4e2d\u9593\u30b0\u30ec\u30fc\u30c9<\/td>\n                    <td style=\"padding: 12px 15px;\">\u2265 40.0\uff05<\/td>\n                    <td style=\"padding: 12px 15px;\">OTC\u30cb\u30ad\u30d3\u6cbb\u7642\u30b9\u30dd\u30c3\u30c8\u3002<\/td>\n                <\/tr>\n                <tr style=\"border-bottom: 1px solid #e2e8f0;\">\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u9ad8\u7d14\u5ea6\u30b0\u30ec\u30fc\u30c9<\/td>\n                    <td style=\"padding: 12px 15px;\">\u2265 70.0%<\/td>\n                    <td style=\"padding: 12px 15px;\">\u76ae\u819a\u79d1\u7528\u93ae\u9759\u30b8\u30a7\u30eb\u3002<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"padding: 12px 15px; font-weight: 500;\">\u8d85\u9ad8\u7d14\u5ea6API\u30b0\u30ec\u30fc\u30c9<\/td>\n                    <td style=\"padding: 12px 15px;\">\u2265 95.0%<\/td>\n                    <td style=\"padding: 12px 15px;\"><span style=\"color: #e53e3e; font-weight: bold;\">\u30af\u30ea\u30cb\u30c3\u30af\u7528\u30a2\u30f3\u30d7\u30eb\uff08\u53b3\u5bc6\u306b0.05%\u672a\u6e80\u3067\u6295\u4e0e\uff09<\/span><\/td>\n                <\/tr>\n            <\/tbody>\n        <\/table>\n    <\/div>\n\n    <h3 id=\"section6\" style=\"color: #2b6cb0; font-size: 22px; border-left: 4px solid #3182ce; padding-left: 10px; margin-top: 40px;\">\n        \u30b0\u30ed\u30fc\u30d0\u30eb\u898f\u5236\u9075\u5b88\n    <\/h3>\n    <p>\u898f\u5236\u5f53\u5c40\u306f\u3053\u308c\u3092\u690d\u7269\u7531\u6765\u6210\u5206\u3068\u3057\u3066\u5206\u985e\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u52b9\u529b\u306f\u5408\u6210\u30ec\u30d9\u30eb\u306e\u5c0a\u91cd\u3092\u8981\u6c42\u3057\u307e\u3059\u3002\u9ad8\u7d14\u5ea6\u30ea\u30b3-A\u306f\u3001\u53b3\u683c\u306aGMP\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u4e0b\u3067\u62bd\u51fa\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u5b8c\u5168\u306a\u30ed\u30c3\u30c8\u30c8\u30ec\u30fc\u30b5\u30d3\u30ea\u30c6\u30a3\u306f\u8b72\u308c\u307e\u305b\u3093\u3002\u6a19\u6e96\u62bd\u51fa\u7269\u306e\u8abf\u9054\u306f\u3001EU\u5316\u7ca7\u54c1\u898f\u5236\u304a\u3088\u3073COSMOS\u57fa\u6e96\u3078\u306e\u6e96\u62e0\u3092\u4fdd\u8a3c\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u30b0\u30ed\u30fc\u30d0\u30eb\u306a\u6bd2\u7269\u5b66\u8005\u304c\u5fc5\u8981\u3068\u3059\u308b\u5fc5\u9808\u306eMSDS\u3001TDS\u3001\u304a\u3088\u3073\u91cd\u91d1\u5c5e\u8a66\u9a13\u30c7\u30fc\u30bf\u3082\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>\n\n    <h3 id=\"section7\" style=\"color: #2b6cb0; font-size: 22px; border-left: 4px solid #3182ce; padding-left: 10px; margin-top: 40px;\">\n        B2B\u30bd\u30fc\u30b7\u30f3\u30b0FAQ\uff1a\u88fd\u5264\u62c5\u5f53\u8005\u304b\u3089\u306e8\u3064\u306e\u91cd\u8981\u306a\u8cea\u554f\n    <\/h3>\n    \n    <div style=\"margin-bottom: 20px;\">\n        <h4 style=\"color: #2d3748; font-size: 16px; margin-bottom: 5px;\">Q1\uff1a\u7d14\u7c8b\u306a\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u306e\u6b63\u78ba\u306a\u6eb6\u89e3\u30d7\u30ed\u30c8\u30b3\u30eb\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h4>\n        <p style=\"margin-top: 0; color: #4a5568;\">\u975e\u5e38\u306b\u89aa\u6cb9\u6027\u3067\u3059\u3002\u6c34\u3092\u5b8c\u5168\u306b\u62d2\u5426\u3057\u307e\u3059\u3002\u4e92\u63db\u6027\u306e\u3042\u308b\u30b0\u30ea\u30b3\u30fc\u30eb\uff08\u30da\u30f3\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u3084\u30d6\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306a\u3069\uff09\u307e\u305f\u306f\u4e2d\u9396\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30aa\u30a4\u30eb\u306b\u4e8b\u524d\u306b\u6eb6\u89e3\u3057\u3066\u304b\u3089\u3001\u76f8\u306b\u7d71\u5408\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n    <\/div>\n\n    <div style=\"margin-bottom: 20px;\">\n        <h4 style=\"color: #2d3748; font-size: 16px; margin-bottom: 5px;\">Q2\uff1a\u306a\u305c95%\u7d14\u7c8b\u306a\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u30921.0%\u307e\u305f\u306f2.0%\u3067\u6295\u4e0e\u3059\u308b\u306e\u304c\u9593\u9055\u3044\u306a\u306e\u3067\u3059\u304b\uff1f<\/h4>\n        <p style=\"margin-top: 0; color: #4a5568;\">\u7d30\u80de\u6bd2\u6027\u3067\u3059\u3002\u9ad8\u7d14\u5ea6\u30ea\u30b3-A\u306f\u975e\u5e38\u306b\u5f37\u529b\u3067\u3059\u300295%\u30b0\u30ec\u30fc\u30c9\u306e0.1%\u3092\u8d85\u3048\u308b\u6295\u5165\u91cf\u306f\u3001\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u306e\u751f\u5b58\u7387\u306e\u95be\u5024\u3092\u8d85\u3048\u3001\u307e\u3055\u306b\u3042\u306a\u305f\u304c\u9632\u3054\u3046\u3068\u3057\u3066\u3044\u308b\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u30020.01% \u2013 0.05%\u306b\u7559\u3081\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n    <\/div>\n\n    <div style=\"margin-bottom: 20px;\">\n        <h4 style=\"color: #2d3748; font-size: 16px; margin-bottom: 5px;\">Q3\uff1a\u900f\u660e\u306a\u30cb\u30ad\u30d3\u7528\u7f8e\u5bb9\u6db2\u306e\u6a19\u6e96\u7684\u306aHPLC\u7d14\u5ea6\u30b0\u30ec\u30fc\u30c9\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h4>\n        <p style=\"margin-top: 0; color: #4a5568;\">70%\u307e\u305f\u306f95%\u30b0\u30ec\u30fc\u30c9\u3067\u3059\u3002\u4f4e\u7d14\u5ea6\uff0820-40%\uff09\u306b\u306f\u3001\u900f\u660e\u306a\u30b8\u30a7\u30eb\u30b7\u30b9\u30c6\u30e0\u306e\u7f8e\u89b3\u3092\u640d\u306a\u3046\u91cd\u3044\u8336\u8272\/\u9ec4\u8272\u306e\u8272\u5408\u3044\u3092\u4e0e\u3048\u308b\u6b8b\u7559\u690d\u7269\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n    <\/div>\n\n    <div style=\"margin-bottom: 20px;\">\n        <h4 style=\"color: #2d3748; font-size: 16px; margin-bottom: 5px;\">Q4\uff1aCAS 58749-22-7\u306f\u3069\u306e\u3088\u3046\u306b\u79c1\u306e\u30b5\u30d7\u30e9\u30a4\u30c1\u30a7\u30fc\u30f3\u3092\u4fdd\u8b77\u3057\u307e\u3059\u304b\uff1f<\/h4>\n        <p style=\"margin-top: 0; color: #4a5568;\">\u7acb\u4f53\u5316\u5b66\u7684\u306a\u771f\u6b63\u6027\u3092\u4fdd\u8a3c\u3057\u307e\u3059\u3002\u30b5\u30d7\u30e9\u30a4\u30e4\u30fc\u304c\u5b89\u4fa1\u306a\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u30b8\u30ab\u30ea\u30a6\u30e0\u307e\u305f\u306f\u672a\u7cbe\u88fd\u306e\u7518\u8349\u6839\u7c89\u672b\u3092\u5358\u96e2\u3055\u308c\u305f\u30ec\u30c8\u30ed\u30ab\u30eb\u30b3\u30f3\u3068\u3057\u3066\u507d\u88c5\u3059\u308b\u306e\u3092\u9632\u304e\u307e\u3059\u3002<\/p>\n    <\/div>\n\n    <div style=\"margin-bottom: 20px;\">\n        <h4 style=\"color: #2d3748; font-size: 16px; margin-bottom: 5px;\">Q5\uff1a\u88fd\u9020\u4e2d\u306b\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u306f\u4f55\u5ea6\u306e\u6e29\u5ea6\u3067\u5206\u89e3\u3057\u307e\u3059\u304b\uff1f<\/h4>\n        <p style=\"margin-top: 0; color: #4a5568;\">80\u00b0C\u4ee5\u4e0a\u306b\u9577\u6642\u9593\u4fdd\u6301\u3059\u308b\u3068\u3001\u9855\u8457\u306a\u5206\u89e3\u304c\u59cb\u307e\u308a\u307e\u3059\u3002\u4e73\u5316\u76f4\u524d\u306b\u6cb9\u76f8\u306b\u6dfb\u52a0\u3059\u308b\u304b\u3001\u30d7\u30ec\u30df\u30c3\u30af\u30b9\u3092\u4f7f\u7528\u3057\u306645\u00b0C\u672a\u6e80\u306e\u51b7\u5374\u6bb5\u968e\u3067\u5c0e\u5165\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n    <\/div>\n\n    <div style=\"margin-bottom: 20px;\">\n        <h4 style=\"color: #2d3748; font-size: 16px; margin-bottom: 5px;\">Q6\uff1a\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u3092L-\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff08\u30d3\u30bf\u30df\u30f3C\uff09\u3068\u914d\u5408\u3067\u304d\u307e\u3059\u304b\uff1f<\/h4>\n        <p style=\"margin-top: 0; color: #4a5568;\">\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u4e21\u65b9\u3068\u3082\u8272\u7d20\u6c88\u7740\u904e\u5270\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\u304c\u3001\u7d14\u7c8b\u306aL-\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u306f\u975e\u5e38\u306b\u9178\u6027\u306apH\uff08&lt; 3.5\uff09\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u3002\u30ea\u30b3-A\u306fpH 4.5\uff5e6.5\u3067\u3088\u308a\u5b89\u5b9a\u3067\u3059\u3002\u4ee3\u308f\u308a\u306b\u5b89\u5b9a\u306a\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53\uff08MAP\u307e\u305f\u306fSAP\u306a\u3069\uff09\u306e\u4f7f\u7528\u3092\u691c\u8a0e\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n    <\/div>\n\n    <div style=\"margin-bottom: 20px;\">\n        <h4 style=\"color: #2d3748; font-size: 16px; margin-bottom: 5px;\">Q7\uff1a\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u306f\u306b\u5bfe\u3057\u3066\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u304b\uff1f <em>\u30a2\u30af\u30cd\u83cc<\/em>?<\/h4>\n        <p style=\"margin-top: 0; color: #4a5568;\">\u306f\u3044\u3002in vitro MIC\u30c7\u30fc\u30bf\u306f\u3001\u305d\u308c\u304c\u7a4d\u6975\u7684\u306b\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3066\u3044\u307e\u3059 <em>C.\u30a2\u30af\u30cd\u30b9<\/em> \u7d30\u80de\u819c\u8cab\u901a\u6392\u51fa\u30dd\u30f3\u30d7\u3092\u7834\u58ca\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u5897\u6b96\u3067\u3042\u308a\u3001\u30cb\u30ad\u30d3\u304c\u3067\u304d\u3084\u3059\u3044\u808c\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u6709\u52b9\u6210\u5206\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n    <\/div>\n\n    <div style=\"margin-bottom: 20px;\">\n        <h4 style=\"color: #2d3748; font-size: 16px; margin-bottom: 5px;\">Q8\uff1a\u5b89\u5b9a\u6027\u8a66\u9a13\u306e\u305f\u3081\u306b\u30ab\u30b9\u30bf\u30e0\u88fd\u5264\u30b5\u30f3\u30d7\u30eb\u3092\u30ea\u30af\u30a8\u30b9\u30c8\u3067\u304d\u307e\u3059\u304b\uff1f<\/h4>\n        <p style=\"margin-top: 0; color: #4a5568;\">\u306f\u3044\u3002\u4fe1\u983c\u3067\u304d\u308b\u539f\u6750\u6599\u30e1\u30fc\u30ab\u30fc\u306f\u3001\u304a\u5ba2\u69d8\u306e\u7279\u5b9a\u306e\u30b7\u30e3\u30fc\u30b7\u306b\u304a\u3051\u308b\u6eb6\u5a92\u9069\u5408\u6027\u3068UV\u5b89\u5b9a\u6027\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001R&amp;D\u6bb5\u968e\u3067\u6a19\u6e96\u5316\u3055\u308c\u305f\u8a66\u9a13\u7528\u6570\u91cf\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n    <\/div>\n\n    <h3 id=\"section8\" style=\"color: #2b6cb0; font-size: 22px; border-left: 4px solid #3182ce; padding-left: 10px; margin-top: 40px;\">\n        \u691c\u8a3c\u6e08\u307f\u79d1\u5b66\u7684\u53c2\u8003\u6587\u732e\n    <\/h3>\n    <ul style=\"color: #4a5568; padding-left: 20px; font-size: 14px;\">\n        <li style=\"margin-bottom: 8px;\">Cayman Chemical \u5206\u6790\u30c7\u30fc\u30bf\u3002 <em>\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\uff08CAS: 58749-22-7\uff09\u88fd\u54c1\u60c5\u5831\u3001\u6eb6\u89e3\u6027\u3001\u304a\u3088\u3073\u5316\u5b66\u7684\u7279\u6027<\/em>.<\/li>\n        <li style=\"margin-bottom: 8px;\">\u67f4\u7530 \u8aa0 \u4ed6 (1991) <em>\u7518\u8349\u5c5e\u306e\u5316\u5b66\u3068\u85ac\u7406\u5b66<\/em>Journal of Pharmacy and Pharmacology.<\/li>\n        <li style=\"margin-bottom: 8px;\">Kim, J. \u4ed6 (2013) <em>\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306f\u3001\u30ab\u30b9\u30d1\u30fc\u30bc\u4f9d\u5b58\u6027\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u30d2\u30c8\u7d30\u80de\u306b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b\uff1a\u6bd2\u6027\u95be\u5024\u306e\u8a2d\u5b9a<\/em>Oncology Reports.<\/li>\n        <li style=\"margin-bottom: 8px;\">Eucerin\/Beiersdorf \u81e8\u5e8a\u51fa\u7248\u7269\u3002 <em>\u9152\u3055\u304a\u3088\u3073\u30cb\u30ad\u30d3\u304c\u3067\u304d\u3084\u3059\u3044\u808c\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306e\u6709\u52b9\u6027<\/em>.<\/li>\n    <\/ul>\n\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u85ac\u7269\u52d5\u614b\u5b66\uff1a\u76ae\u819a\u306e\u73fe\u5b9f\u691c\u8a0e<\/p>","protected":false},"author":8,"featured_media":5821,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[62],"tags":[],"class_list":["post-15989","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.8 (Yoast SEO v24.2) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Licochalcone A for Skin: Corrected Formulation Specs, IC50 Benchmarks, and Clinical Realities - Shaanxi Huatai Bio-Fine Chemical Co., Ltd.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/glabridinchina.com\/ja\/licochalcone-a-for-skin-corrected-formulation-specs-ic50-benchmarks-and-clinical-realities\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Licochalcone A for Skin: Corrected Formulation Specs, IC50 Benchmarks, and Clinical Realities\" \/>\n<meta property=\"og:description\" content=\"Table of Contents 1. 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