{"id":15388,"date":"2026-07-14T09:04:01","date_gmt":"2026-07-14T09:04:01","guid":{"rendered":"https:\/\/glabridinchina.com\/?p=15388"},"modified":"2026-07-14T09:04:02","modified_gmt":"2026-07-14T09:04:02","slug":"the-brutal-chemistry-of-alpha-arbutin-and-kojic-acid-ph-conflicts-stability-data-and-compounding-protocols","status":"publish","type":"post","link":"https:\/\/glabridinchina.com\/ja\/the-brutal-chemistry-of-alpha-arbutin-and-kojic-acid-ph-conflicts-stability-data-and-compounding-protocols\/","title":{"rendered":"The Brutal Chemistry of Alpha Arbutin and Kojic Acid: pH Conflicts, Stability Data, and Compounding Protocols"},"content":{"rendered":"

\u5316\u7ca7\u54c1\u88fd\u9020\u30e9\u30dc\u306b\u5165\u308a\u3001\u4e3b\u4efb\u5316\u5b66\u8005\u306b\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u3068\u30b3\u30a6\u30b8\u9178\u306e\u6df7\u5408\u3092\u4f9d\u983c\u3057\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002\u5f7c\u3089\u306e\u9854\u8272\u304c\u843d\u3061\u308b\u306e\u3092\u898b\u3066\u304f\u3060\u3055\u3044\u3002<\/p>

\u30d6\u30e9\u30f3\u30c9\u306f\u3053\u306e\u7d44\u307f\u5408\u308f\u305b\u3092\u7406\u8ad6\u4e0a\u306f\u6c17\u306b\u5165\u3063\u3066\u3044\u307e\u3059\u3002\u3069\u3061\u3089\u306e\u6210\u5206\u3082\u8272\u7d20\u6c88\u7740\u904e\u5270\u306b\u52b9\u679c\u7684\u306b\u4f5c\u7528\u3057\u307e\u3059\u3002\u51e6\u65b9\u8005\u306f\u901a\u5e38\u3001\u305d\u308c\u3089\u3092\u4e00\u7dd2\u306b\u6271\u3046\u3053\u3068\u3092\u5acc\u3044\u307e\u3059\u3002\u5148\u6708\u3001\u3042\u308b\u30af\u30e9\u30a4\u30a2\u30f3\u30c8\u304c\u30d7\u30ec\u30df\u30a2\u30e0\u7f8e\u767d\u7f8e\u5bb9\u6db2\u306e\u5168\u751f\u7523\u30ed\u30c3\u30c8\u3092\u5ec3\u68c4\u3059\u308b\u306e\u3092\u898b\u307e\u3057\u305f\u3002\u6e29\u304b\u3044\u5009\u5eab\u306b3\u9031\u9593\u7f6e\u3044\u305f\u3060\u3051\u3067\u3082\u3001\u6db2\u4f53\u306f\u53e4\u304f\u9178\u5316\u3057\u305f\u30da\u30cb\u30fc\u306e\u3088\u3046\u306a\u8272\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>

\u8272\u306e\u5909\u5316\u3088\u308a\u3082\u60aa\u3044\u3053\u3068\u306f\u4f55\u3067\u3057\u3087\u3046\u304b\uff1f\u7f8e\u5bb9\u6db2\u306f\u6280\u8853\u7684\u306b\u9055\u6cd5\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>

\u5f37\u529b\u306a\u6709\u52b9\u6210\u5206\u30922\u3064\u6c34\u30d9\u30fc\u30b9\u306b\u6df7\u305c\u3066\u3001\u6700\u826f\u306e\u7d50\u679c\u3092\u671f\u5f85\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u6df7\u5408\u30bf\u30f3\u30af\u5185\u306e\u5b9f\u969b\u306e\u5316\u5b66\u7684\u6226\u5834\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>

\"\u30b3\u30a6\u30b8\u9178\"<\/figure><\/div>

\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u3068\u30b3\u30a6\u30b8\u9178\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u540c\u3058\u90e8\u4f4d\u3001\u3059\u306a\u308f\u3061\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u9175\u7d20\u3067\u653b\u6483\u3057\u307e\u3059\u3002\u30b3\u30a6\u30b8\u9178\u306f\u722a\u306e\u3088\u3046\u306a\u50cd\u304d\u3092\u3057\u307e\u3059\u3002\u9175\u7d20\u306e\u6a5f\u80fd\u306b\u5fc5\u8981\u306a\u9285\u30a4\u30aa\u30f3\u3092\u30ad\u30ec\u30fc\u30c8\u3057\u3001\u52b9\u679c\u7684\u306b\u6a5f\u68b0\u3092\u7834\u58ca\u3057\u307e\u3059\u3002\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u30c7\u30b3\u30a4\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002\u30e1\u30e9\u30cb\u30f3\u306e\u5929\u7136\u306e\u69cb\u6210\u8981\u7d20\u3092\u6a21\u5023\u3057\u3001\u7af6\u5408\u963b\u5bb3\u306b\u3088\u3063\u3066\u9175\u7d20\u306e\u30ae\u30a2\u3092\u8a70\u307e\u3089\u305b\u307e\u3059\u3002<\/p>

\u76f8\u4e57\u52b9\u679c\u306f\u5de8\u5927\u3067\u3059\u3002\u5b89\u5b9a\u6027\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u60aa\u5922\u3067\u3059\u3002<\/p>

\u30b3\u30a6\u30b8\u9178\u306f\u975e\u5e38\u306b\u53cd\u5fdc\u6027\u304c\u9ad8\u3044\u3067\u3059\u3002\u7a7a\u6c17\u3084\u7d2b\u5916\u7dda\u306b\u3055\u3089\u3055\u308c\u308b\u3068\u6025\u901f\u306b\u9178\u5316\u3057\u3001\u6697\u8910\u8272\u306e\u30dd\u30ea\u30de\u30fc\u5316\u5408\u7269\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u6c34\u4e2d\u306e\u5fae\u91cf\u306e\u9244\uff08Fe3+\uff09\u3068\u6fc0\u3057\u304f\u7d50\u5408\u3057\u3001\u6eb6\u6db2\u3092\u307b\u307c\u77ac\u6642\u306b\u8840\u306e\u3088\u3046\u306a\u8d64\u8272\u307e\u305f\u306f\u6697\u8910\u8272\u306b\u5909\u3048\u307e\u3059\u3002<\/p>

\u3057\u304b\u3057\u3001\u6700\u5927\u306e\u8105\u5a01\u306fpH\u306e\u7af6\u5408\u3067\u3059\u3002<\/p>

\u30b3\u30a6\u30b8\u9178\u306f\u672c\u8cea\u7684\u306b\u9178\u6027\u3067\u3059\u3002\u6c34\u306b\u52a0\u3048\u308b\u3068\u3001pH\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u30b0\u30ea\u30b3\u30b7\u30c9\u3067\u3059\u30024.5\u304b\u30896.5\u306e\u5b89\u5b9a\u3057\u305fpH\u74b0\u5883\u304c\u5fc5\u8981\u3067\u3059\u3002\u30b3\u30a6\u30b8\u9178\u304c\u51e6\u65b9pH\u30924.0\u672a\u6e80\u306b\u5f15\u304d\u4e0b\u3052\u308b\u3068\u3001\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u30b0\u30ea\u30b3\u30b7\u30c9\u7d50\u5408\u304c\u7834\u58ca\u3055\u308c\u59cb\u3081\u307e\u3059\u3002\u3053\u306e\u52a0\u6c34\u5206\u89e3\u53cd\u5fdc\u306b\u3088\u308a\u3001\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u304c\u7f8e\u5bb9\u6db2\u306b\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u306f\u3001\u4e16\u754c\u306e\u307b\u3068\u3093\u3069\u306e\u5e02\u5834\u3067\u5316\u7ca7\u54c1\u3067\u306f\u53b3\u3057\u304f\u7981\u6b62\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>

\u7de9\u885d\u5316\u3055\u308c\u3066\u3044\u306a\u3044\u30b3\u30a6\u30b8\u9178\u3068\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u7f8e\u5bb9\u6db2\u306f\u3001\u5358\u306b\u8336\u8272\u306b\u306a\u308b\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u306f\u6709\u6bd2\u3067\u898f\u5236\u306b\u6e96\u62e0\u3057\u306a\u3044\u5371\u967a\u7269\u306b\u5206\u89e3\u3055\u308c\u307e\u3059\u3002<\/p>

\u3053\u308c\u3089\u306e\u539f\u6599\u3092\u30c8\u30f3\u5358\u4f4d\u3067\u88fd\u9020\u3059\u308b\u30e1\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3001\u79c1\u305f\u3061\u306f\u5fb9\u5e95\u7684\u306a\u5206\u6790\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002\u7cbe\u88fd\u3055\u308c\u3066\u3044\u306a\u3044\u5b89\u4fa1\u306a\u7c89\u672b\u3092\u8cfc\u5165\u3057\u305f\u305f\u3081\u306b\u3001\u30d6\u30e9\u30f3\u30c9\u304c\u7e70\u308a\u8fd4\u3057\u5931\u6557\u3059\u308b\u306e\u3092\u898b\u3066\u304d\u307e\u3057\u305f\u3002\u30b5\u30d7\u30e9\u30a4\u30e4\u30fc\u306b\u53b3\u683c\u306a\u4ed5\u69d8\u3092\u8981\u6c42\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>

\u3053\u3053\u306b\u3001\u5b89\u5b9a\u6027\u3068\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u3092\u4fdd\u8a3c\u3059\u308b\u305f\u3081\u306b\u5f53\u793e\u304c\u5b9f\u65bd\u3059\u308b\u5206\u6790\u8a3c\u660e\u66f8\uff08COA\uff09\u306e\u30d9\u30f3\u30c1\u30de\u30fc\u30af\u3092\u793a\u3057\u307e\u3059\u3002<\/p>

\u539f\u6750\u6599\u54c1\u8cea\u4ed5\u69d8\uff08COA\u30d9\u30f3\u30c1\u30de\u30fc\u30af\uff09<\/h3>
Analytical Parameter<\/strong><\/td>\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\uff08\u9ad8\u7d14\u5ea6\uff09<\/strong><\/td>\u30b3\u30a6\u30b8\u9178\uff08\u5316\u7ca7\u54c1\u30b0\u30ec\u30fc\u30c9\uff09<\/strong><\/td><\/tr><\/thead>
\u5916\u89b3<\/strong><\/td>\u767d\u8272\u7d50\u6676\u6027\u7c89\u672b<\/td>\u307b\u307c\u767d\u8272\u306e\u7d50\u6676\u6027\u7c89\u672b<\/td><\/tr>
\u7d14\u5ea6\uff08HPLC\uff09<\/strong><\/td>\u2265 99.5%<\/td>\u2265 99.8%<\/td><\/tr>
\u6bd4\u65cb\u5149\u5ea6<\/strong><\/td>+174.0\u00b0\uff5e+186.0\u00b0<\/td>\u8a72\u5f53\u306a\u3057<\/td><\/tr>
\u91cd\u91d1\u5c5e\uff08\u5408\u8a08\uff09<\/strong><\/td>\u2264 10 ppm<\/td>\u2264 10 ppm<\/td><\/tr>
\u9244\uff08Fe3+\uff09\u5236\u9650<\/strong><\/td>\u2264 2 ppm<\/td>1 ppm\u4ee5\u4e0b<\/td><\/tr>
\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u5236\u9650<\/strong><\/td>\u2264 10 ppm<\/td>\u8a72\u5f53\u306a\u3057<\/td><\/tr>
\u4e7e\u71e5\u6e1b\u91cf<\/strong><\/td>\u2264 0.5%<\/td>\u2264 0.5%<\/td><\/tr><\/tbody><\/table><\/figure>

\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u6bd4\u65cb\u5149\u5ea6\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u3053\u308c\u306f\u3001\u5b89\u4fa1\u3067\u5b89\u5b9a\u6027\u306e\u4f4e\u3044\u300c\u30d9\u30fc\u30bf\u300d\u7570\u6027\u4f53\u3067\u306f\u306a\u304f\u3001\u975e\u5e38\u306b\u52b9\u679c\u7684\u306a\u300c\u30a2\u30eb\u30d5\u30a1\u300d\u7570\u6027\u4f53\u3092\u53d6\u5f97\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u307e\u3059\u3002\u30b3\u30a6\u30b8\u9178\u306e\u9244\u5236\u9650\u3092\u898b\u3066\u304f\u3060\u3055\u3044\u3002\u5f53\u793e\u306f\u305d\u308c\u30921 ppm\u672a\u6e80\u306b\u5236\u9650\u3057\u3066\u3044\u307e\u3059\u3002\u30b3\u30a6\u30b8\u9178\u306b\u9244\u5206\u304c\u9ad8\u3044\u5834\u5408\u3001\u5145\u586b\u30e9\u30a4\u30f3\u306b\u5230\u9054\u3059\u308b\u524d\u306b\u51e6\u65b9\u304c\u5909\u8272\u3057\u307e\u3059\u3002<\/p>

\u3053\u306e\u30c7\u30e5\u30aa\u3092\u5b9f\u969b\u306b\u5b89\u5b9a\u3055\u305b\u308b\u306b\u306f\u3069\u3046\u3059\u308c\u3070\u3088\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>

\u5f53\u793e\u306f\u3001\u5b9f\u9a13\u5ba4\u306745\u65e5\u9593\u306e\u52a0\u901f\u5b89\u5b9a\u6027\u304a\u3088\u3073\u71b1\u30a2\u30c3\u30bb\u30a4\uff0845\u2103\uff09\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002\u6a19\u6e96\u7684\u306a2%\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u30681%\u30b3\u30a6\u30b8\u9178\u306e\u6c34\u6027\u30d9\u30fc\u30b9\u306e\u5206\u89e3\u3092\u8ffd\u8de1\u3057\u307e\u3057\u305f\u3002\u8272\u306e\u5909\u5316\u3001\u6d3b\u6027\u7269\u8cea\u306e\u4fdd\u6301\u3001\u305d\u3057\u3066\u6700\u3082\u91cd\u8981\u306a\u3053\u3068\u306b\u3001\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3\u306e\u751f\u6210\u3092\u76e3\u8996\u3057\u307e\u3057\u305f\u3002<\/p>

45\u65e5\u9593\u52a0\u901f\u5b89\u5b9a\u6027\u30a2\u30c3\u30bb\u30a4\uff0845\u2103 + \u7d2b\u5916\u7dda\u66b4\u9732\uff09<\/h3>
\u51e6\u65b9\u30d7\u30ed\u30c8\u30b3\u30eb<\/strong><\/td>\u7de9\u885d\/\u4fdd\u8b77\u30b7\u30b9\u30c6\u30e0<\/strong><\/td>pH\u30c9\u30ea\u30d5\u30c8\uff080\u65e5\u76ee\uff5e45\u65e5\u76ee\uff09<\/strong><\/td>\u6d3b\u6027\u30b3\u30a6\u30b8\u9178\u4fdd\u6301\u7387<\/strong><\/td>\u691c\u51fa\u3055\u308c\u305f\u30d2\u30c9\u30ed\u30ad\u30ce\u30f3<\/strong><\/td><\/tr><\/thead>
\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff08\u672a\u7de9\u885d\uff09<\/strong><\/td>\u306a\u3057<\/td>8 \u2192 3.6<\/td>3%\uff08\u6fc3\u8910\u8272\uff09<\/td>145 ppm\uff08\u5931\u683c\uff09<\/td><\/tr>
\u30d7\u30ed\u30c8\u30b3\u30ebA<\/strong><\/td>1% EDTA<\/td>8 \u2192 4.1<\/td>68%\uff08\u9ec4\u8272\uff09<\/td>35 ppm\uff08\u5931\u683c\uff09<\/td><\/tr>
\u30d7\u30ed\u30c8\u30b3\u30ebB<\/strong><\/td>1% EDTA + 0.2%\u4e9c\u786b\u9178\u6c34\u7d20\u30ca\u30c8\u30ea\u30a6\u30e0<\/td>8 \u2192 4.3<\/td>89%\uff08\u6de1\u9ec4\u8272\uff09<\/td>12 ppm\uff08\u5883\u754c\u7dda\uff09<\/td><\/tr>
\u6700\u9069\u5316\u30d7\u30ed\u30c8\u30b3\u30eb<\/strong><\/td>EDTA + \u4e9c\u786b\u9178\u5869 + \u30af\u30a8\u30f3\u9178\/\u30af\u30a8\u30f3\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u7de9\u885d\u6db2<\/td>2 \u2192 5.1<\/td>97%\uff08\u900f\u660e\uff09<\/td>\u672a\u691c\u51fa\uff08\u5408\u683c\uff09<\/td><\/tr><\/tbody><\/table><\/figure>

\u751f\u30c7\u30fc\u30bf\u306f\u3001\u51e6\u65b9\u306e\u73fe\u5b9f\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3059\u3002\u30ad\u30ec\u30fc\u30c8\u5264\uff08EDTA\uff09\u3092\u8ffd\u52a0\u3059\u308b\u3060\u3051\u3067\u306f\u4e0d\u5341\u5206\u3067\u3059\u3002\u6297\u9178\u5316\u5264\uff08\u4e9c\u786b\u9178\u6c34\u7d20\u30ca\u30c8\u30ea\u30a6\u30e0\uff09\u3092\u8ffd\u52a0\u3059\u308b\u3060\u3051\u3067\u306f\u4e0d\u5341\u5206\u3067\u3059\u3002pH\u3092\u56fa\u5b9a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u6700\u9069\u5316\u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u306f\u3001\u30af\u30a8\u30f3\u9178\u3068\u30af\u30a8\u30f3\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u7de9\u885d\u30b7\u30b9\u30c6\u30e0\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001pH\u304c5.2\u306b\u3057\u3063\u304b\u308a\u3068\u4fdd\u6301\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30b3\u30a6\u30b8\u9178\u304c\u6c34\u3092\u9178\u6027\u5316\u3059\u308b\u306e\u3092\u9632\u304e\u3001\u305d\u306e\u7d50\u679c\u3001\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u304c\u52a0\u6c34\u5206\u89e3\u3055\u308c\u308b\u306e\u3092\u9632\u304e\u307e\u3059\u3002<\/p>

\u79c1\u305f\u3061\u306f\u7814\u7a76\u958b\u767a\u30d1\u30fc\u30c8\u30ca\u30fc\u306b\u3001\u3053\u306e\u7d44\u307f\u5408\u308f\u305b\u306e\u305f\u3081\u306e3\u3064\u306e\u7d76\u5bfe\u7684\u306a\u914d\u5408\u30eb\u30fc\u30eb\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>

  1. pH\u3092\u56fa\u5b9a\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/strong> \u6d3b\u6027\u7269\u8cea\u3092\u8ffd\u52a0\u3059\u308b\u524d\u306b\u7de9\u885d\u30b7\u30b9\u30c6\u30e0\u3092\u4f5c\u6210\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u53b3\u683c\u306apH 5.0\uff5e5.5\u3092\u76ee\u6a19\u3068\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/li>\n\n
  2. \u91d1\u5c5e\u3092\u5c01\u3058\u8fbc\u3081\u3066\u304f\u3060\u3055\u3044\u3002<\/strong> \u52a0\u71b1\u6c34\u76f8\u306b0.1% EDTA\u4e8c\u30ca\u30c8\u30ea\u30a6\u30e0\u3092\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u30b3\u30a6\u30b8\u9178\u3092\u5c0e\u5165\u3059\u308b\u524d\u306b\u3001\u3059\u3079\u3066\u306e\u5fae\u91cf\u306e\u91d1\u5c5e\u3092\u6355\u6349\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n\n
  3. \u9178\u7d20\u6355\u6349\u5264\u3092\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/strong> \u4e9c\u786b\u9178\u6c34\u7d20\u30ca\u30c8\u30ea\u30a6\u30e0\uff080.1%\uff5e0.2%\uff09\u3092\u8ffd\u52a0\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u30b3\u30a6\u30b8\u9178\u304c\u305d\u3046\u3059\u308b\u5fc5\u8981\u304c\u306a\u3044\u3088\u3046\u306b\u3001\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u3092\u5f15\u304d\u53d7\u3051\u307e\u3059\u3002\u306f\u3044\u3001\u308f\u305a\u304b\u306a\u786b\u9ec4\u81ed\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30f3\u30c6\u30ea\u30b8\u30a7\u30f3\u30c8\u306b\u30de\u30b9\u30ad\u30f3\u30b0\u3057\u306a\u3044\u3068\u3001\u88fd\u54c1\u306f\u5931\u6557\u3057\u307e\u3059\u3002<\/li>\n\n
  4. \u51b7\u9593\u52a0\u5de5\u306e\u307f\u3002<\/strong> \u3069\u3061\u3089\u306e\u6210\u5206\u3082\u71b1\u306b\u975e\u5e38\u306b\u5f31\u3044\uff08\u30b5\u30fc\u30e2\u30e9\u30d3\u30ea\u30c6\u30a3\u304c\u9ad8\u3044\uff09\u3067\u3059\u300240\u2103\u3092\u8d85\u3048\u308b\u6e29\u5ea6\u306b\u7d76\u5bfe\u306b\u3055\u3089\u3055\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002\u5ba4\u6e29\u306e\u6c34\u306b\u4e88\u5099\u6eb6\u89e3\u3057\u3001\u6700\u7d42\u51b7\u5374\u6bb5\u968e\u3067\u6dfb\u52a0\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/li><\/ol>

    \u898f\u5236\u74b0\u5883\u306f\u4e16\u754c\u7684\u306b\u53b3\u3057\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u6b27\u5ddeSCCS\uff08\u6d88\u8cbb\u8005\u5b89\u5168\u79d1\u5b66\u59d4\u54e1\u4f1a\uff09\u306f\u5b89\u5168\u30de\u30fc\u30b8\u30f3\u3092\u6700\u7d42\u6c7a\u5b9a\u3057\u307e\u3057\u305f\u3002\u30b3\u30a6\u30b8\u9178\u306f\u9854\u304a\u3088\u3073\u624b\u7528\u88fd\u54c1\u3067\u306f1%\u306b\u53b3\u3057\u304f\u5236\u9650\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306f\u3001\u9854\u7528\u30af\u30ea\u30fc\u30e0\u3067\u306f\u6700\u59272%\u307e\u3067\u8a31\u53ef\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>

    4%\u306e\u30b3\u30a6\u30b8\u9178\u3067\u808c\u306e\u660e\u308b\u3055\u3092\u7121\u7406\u3084\u308a\u6539\u5584\u3059\u308b\u3053\u3068\u306f\u3082\u3046\u3067\u304d\u307e\u305b\u3093\u3002\u6cd5\u5f8b\u3067\u7981\u6b62\u3055\u308c\u3066\u3044\u307e\u3059\u30022%\u306e\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u30681%\u306e\u30b3\u30a6\u30b8\u9178\u306e\u6b63\u78ba\u3067\u8a08\u7b97\u3055\u308c\u305f\u76f8\u4e57\u52b9\u679c\u306b\u983c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\u3001\u7de9\u885d\u30d7\u30ed\u30c8\u30b3\u30eb\u3001\u304a\u3088\u3073\u539f\u6750\u6599\u306e\u7d14\u5ea6\u304c\u5b8c\u74a7\u3067\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/p>

    \u5f53\u793e\u306f\u3001\u4e16\u754c\u4e2d\u306e\u88fd\u9020\u65bd\u8a2d\u306b\u7d14\u7c8b\u3067\u975e\u5e38\u306b\u5b89\u5b9a\u3057\u305f\u5316\u7ca7\u54c1\u6709\u52b9\u6210\u5206\u3092\u4f9b\u7d66\u3057\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u958b\u767a\u5316\u5b66\u8005\u304c\u81ea\u8eab\u306e\u30d9\u30f3\u30c1\u3067\u3053\u308c\u3089\u306e\u5b89\u5b9a\u6027\u8a66\u9a13\u3092\u518d\u73fe\u3067\u304d\u308b\u3088\u3046\u306b\u3001\u6b63\u78ba\u306a\u30e9\u30dc\u30b5\u30f3\u30d7\u30eb\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u9ad8\u6027\u80fd\u30b9\u30ad\u30f3\u30b1\u30a2\u306f\u3001\u59a5\u5354\u306e\u306a\u3044\u539f\u6750\u6599\u304b\u3089\u59cb\u307e\u308a\u307e\u3059\u3002\u5b89\u4fa1\u3067\u4e0d\u5b89\u5b9a\u306a\u7c89\u672b\u3067\u3001\u5316\u5b66\u7684\u306b\u512a\u308c\u305f\u51e6\u65b9\u3092\u53f0\u7121\u3057\u306b\u3057\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/p>

    \u53c2\u7167\u304a\u3088\u3073\u53c2\u7167\u3055\u308c\u305f\u516c\u958b\u30c7\u30fc\u30bf\u30bd\u30fc\u30b9\uff1a<\/strong><\/p>

    • SCCS\uff08\u6d88\u8cbb\u8005\u5b89\u5168\u79d1\u5b66\u59d4\u54e1\u4f1a\uff09\u3001\u30b3\u30a6\u30b8\u9178\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u610f\u898b\uff08SCCS\/1637\/21\uff09\u30022022\u5e743\u6708\u63a1\u629e\u306e\u6700\u7d42\u7248\u3002<\/li>\n\n
    • SCCS\u3001\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u610f\u898b\uff08SCCS\/1642\/22\uff09\u30022023\u5e743\u6708\u63a1\u629e\u306e\u6700\u7d42\u7248\u3002<\/li>\n\n
    • Burnett, C. L.\u4ed6\u3002\u300c\u5316\u7ca7\u54c1\u306b\u4f7f\u7528\u3055\u308c\u308b\u30b3\u30a6\u30b8\u9178\u306e\u5b89\u5168\u6027\u8a55\u4fa1\u306b\u95a2\u3059\u308b\u6700\u7d42\u5831\u544a\u66f8\u300d\u3002 International Journal of Toxicology<\/em> 6 (2010): 244S-273S\u3002<\/li>\n\n
    • Smit, N., Vicanova, J., & Pavel, S.\u300c\u5929\u7136\u306e\u7f8e\u767d\u6210\u5206\u3092\u63a2\u3057\u3066\u300d\u3002 \u56fd\u969b\u5206\u5b50\u79d1\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb<\/em> 12 (2009): 5326-5349\u3002<\/li><\/ul>","protected":false},"excerpt":{"rendered":"

      \u3069\u3093\u306a\u5316\u7ca7\u54c1\u88fd\u9020\u30e9\u30dc\u306b\u5165\u3063\u3066\u3001\u4e3b\u4efb\u5316\u5b66\u8005\u306b\u30a2\u30eb\u30d5\u30a1\u30a2\u30eb\u30d6\u30c1\u30f3\u3068\u30b3\u30a6\u30b8\u9178\u3092\u6df7\u305c\u308b\u3088\u3046\u306b\u983c\u3093\u3067\u307f\u3066\u304f\u3060\u3055\u3044\u3002\u5f7c\u3089\u306e\u9854\u304c\u66c7\u308b\u306e\u3092\u898b\u308b\u3067\u3057\u3087\u3046\u3002\u30d6\u30e9\u30f3\u30c9\u306f\u3053\u306e\u7d44\u307f\u5408\u308f\u305b\u3092\u597d\u307f\u307e\u3059\u2026<\/p>","protected":false},"author":8,"featured_media":11051,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60],"tags":[],"class_list":["post-15388","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-product-news"],"yoast_head":"\nThe Brutal Chemistry of Alpha Arbutin and Kojic Acid: pH Conflicts, Stability Data, and Compounding Protocols - Shaanxi Huatai Bio-Fine Chemical Co., Ltd.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/glabridinchina.com\/ja\/the-brutal-chemistry-of-alpha-arbutin-and-kojic-acid-ph-conflicts-stability-data-and-compounding-protocols\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Brutal Chemistry of Alpha Arbutin and Kojic Acid: pH Conflicts, Stability Data, and Compounding Protocols\" \/>\n<meta property=\"og:description\" content=\"Walk into any cosmetics manufacturing lab and ask the head chemist to mix Alpha Arbutin with Kojic Acid. 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