{"id":14226,"date":"2026-06-22T09:29:47","date_gmt":"2026-06-22T09:29:47","guid":{"rendered":"https:\/\/glabridinchina.com\/?p=14226"},"modified":"2026-06-22T09:37:06","modified_gmt":"2026-06-22T09:37:06","slug":"glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening","status":"publish","type":"post","link":"https:\/\/glabridinchina.com\/ja\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/","title":{"rendered":"\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\uff1a\u591a\u6bb5\u968e\u7684\u306a\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u306b\u304a\u3051\u308b\u76f8\u88dc\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"14226\" class=\"elementor elementor-14226\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-241d9b7 e-flex e-con-boxed e-con e-parent\" data-id=\"241d9b7\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6081df4 elementor-widget elementor-widget-html\" data-id=\"6081df4\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t  <script type=\"application\/ld+json\">{\n    \"@context\": \"https:\\\/\\\/schema.org\",\n    \"@type\": \"Article\",\n    \"mainEntityOfPage\": {\n        \"@type\": \"WebPage\",\n        \"@id\": \"https:\\\/\\\/glabridinchina.com\\\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\\\/\"\n    },\n    \"headline\": \"Glabridin & Niacinamide: Complementary Mechanisms in Multilevel Brightening\",\n    \"about\": [\n        {\n            \"@type\": \"ChemicalSubstance\",\n            \"name\": \"Glabridin\",\n            \"alternateName\": \"\\u5149\\u7518\\u8349\\u5b9a\"\n        },\n        {\n            \"@type\": \"ChemicalSubstance\",\n            \"name\": \"Niacinamide\",\n            \"alternateName\": \"\\u70df\\u9170\\u80fa\"\n        }\n    ],\n    \"publisher\": {\n        \"@type\": \"Organization\",\n        \"name\": \"Huatai Bio-Fine Chemical\",\n        \"url\": \"https:\\\/\\\/glabridinchina.com\"\n    },\n    \"author\": {\n        \"@type\": \"Organization\",\n        \"name\": \"Huatai Bio-Fine Chemical Technical Team\"\n    },\n    \"datePublished\": \"2026\",\n    \"description\": \"A technical comparison of glabridin and niacinamide as brightening actives, explaining their complementary roles in pigmentation biology and how to combine them for multilevel brightening coverage.\"\n}<\/script>\n\n  <link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n  <link rel=\"preconnect\" href=\"https:\/\/fonts.gstatic.com\" crossorigin>\n  <link href=\"https:\/\/fonts.googleapis.com\/css2?family=Inter:wght@300;400;500;600;700&family=Merriweather:ital,wght@0,400;0,700;1,400&display=swap\" rel=\"stylesheet\">\n\n  <style>\n    :root {\n      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class=\"article-intro\">\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u73fe\u4ee3\u306e\u88fd\u5264\u306b\u304a\u3044\u3066\u6700\u3082\u4e00\u822c\u7684\u306b\u7d44\u307f\u5408\u308f\u3055\u308c\u308b\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u6709\u52b9\u6210\u5206\u306e\u4e00\u3064\u3067\u3059\u3002\u3053\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u8272\u7d20\u6c88\u7740\u751f\u7269\u5b66\u306b\u304a\u3051\u308b\u88dc\u5b8c\u7684\u306a\u5f79\u5272\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u4e3b\u306b\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u95a2\u9023\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u3092\u6a19\u7684\u3068\u3057\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304b\u3089\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u79fb\u3092\u4f4e\u6e1b\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n      <div class=\"byline\">\n        <span><strong>\u83ef\u6cf0\u751f\u7269\u7cbe\u7d30\u5316\u5b66\u54c1<\/strong> \u2014 2008\u5e74\u3088\u308a\u9ad8\u7d14\u5ea6\u5316\u7ca7\u54c1\u6709\u52b9\u6210\u5206\u306e\u88fd\u9020\u5143<\/span>\n        <span style=\"color:var(--color-border)\">\u00b7<\/span>\n        <span>2026\u5e74\u516c\u958b<\/span>\n      <\/div>\n    <\/header>\n\n    <article class=\"article-body\">\n\n      <p>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u73fe\u4ee3\u306e\u88fd\u5264\u306b\u304a\u3044\u3066\u6700\u3082\u4e00\u822c\u7684\u306b\u7d44\u307f\u5408\u308f\u3055\u308c\u308b\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u6709\u52b9\u6210\u5206\u306e\u4e00\u3064\u3067\u3059\u3002\u3053\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u8272\u7d20\u6c88\u7740\u751f\u7269\u5b66\u306b\u304a\u3051\u308b\u88dc\u5b8c\u7684\u306a\u5f79\u5272\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u4e3b\u306b\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u95a2\u9023\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u3092\u6a19\u7684\u3068\u3057\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304b\u3089\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u79fb\u3092\u4f4e\u6e1b\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u5f62\u6210\u304b\u3089\u8868\u76ae\u306b\u304a\u3051\u308b\u76ee\u306b\u898b\u3048\u308b\u8272\u7d20\u6c88\u7740\u306e\u84c4\u7a4d\u307e\u3067\u3001\u8272\u7d20\u6c88\u7740\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3051\u308b\u7570\u306a\u308b\u6bb5\u968e\u306b\u5bfe\u51e6\u3057\u307e\u3059\u3002<\/p>\n\n      <h2>\u3069\u306e\u6210\u5206\u304c\u8272\u7d20\u6c88\u7740\u7d4c\u8def\u306e\u3069\u3053\u306b\u4f5c\u7528\u3059\u308b\u304b<\/h2>\n\n      <p>\u8272\u7d20\u6c88\u7740\u7d4c\u8def\u306f\u3001\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u306e\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u304b\u3089\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u5185\u3067\u306e\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u79fb\u304a\u3088\u3073\u5206\u5e03\u307e\u3067\u3001\u3044\u304f\u3064\u304b\u306e\u6bb5\u968e\u3092\u542b\u307f\u307e\u3059\u3002\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306e\u7570\u306a\u308b\u6bb5\u968e\u3067\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n\n      <h3>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3 \u2014 \u30e1\u30e9\u30cb\u30f3\u5408\u6210\u3068\u4e0a\u6d41\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/h3>\n\n      <p>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u4e3b\u306b\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u5185\u306e\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u6bb5\u968e\u3067\u4f5c\u7528\u3057\u307e\u3059\u3002\u975e\u7af6\u5408\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u4ecb\u3057\u3066\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u963b\u5bb3\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u5408\u6210\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u30b9\u30c6\u30c3\u30d7\u3067\u3042\u308bL-\u30c1\u30ed\u30b7\u30f3\u304b\u3089L-DOPA\u3001\u304a\u3088\u3073L-DOPA\u304b\u3089\u30c9\u30fc\u30d1\u30ad\u30ce\u30f3\u3078\u306e\u5909\u63db\u3092\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001COX\/PGE\u2082\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\uff08Yokota et al., 1998\uff09\u3092\u542b\u3080\u708e\u75c7\u95a2\u9023\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u7d4c\u8def\u3092\u8abf\u7bc0\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n      <p>\u3088\u308a\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306e\u4e0a\u6d41\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6d3b\u6027\u304c\u3055\u3089\u306b\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306b\u304a\u3051\u308bPKA\/MITF\u304a\u3088\u3073MAPK\/MITF\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u4e21\u65b9\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001MC1R\u3001MITF\u3001TYR\u3001TRP-1\u3001TRP-2\u3092\u542b\u3080\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u95a2\u9023\u56e0\u5b50\u306e\u8ee2\u5199\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u3092\u8457\u3057\u304f\u4e0b\u65b9\u5236\u5fa1\u3057\u307e\u3059\uff08Pan et al., 2023\uff09\u3002\u3053\u308c\u306f\u3001\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u304c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u4e0a\u6d41\uff08MITF\u99c6\u52d5\u9175\u7d20\u767a\u73fe\u306e\u4f4e\u6e1b\uff09\u3068\u9175\u7d20\u30ec\u30d9\u30eb\uff08\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u89e6\u5a92\u6d3b\u6027\u306e\u76f4\u63a5\u963b\u5bb3\uff09\u306e\u4e21\u65b9\u3067\u4f5c\u7528\u3059\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/p>\n\n      <p>\u7d50\u679c\uff1a\u30e1\u30e9\u30cb\u30f3\u306e\u751f\u6210\u304c\u5c11\u306a\u304f\u306a\u308a\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u5185\u306e\u30e1\u30e9\u30cb\u30f3\u542b\u6709\u91cf\u304c\u6e1b\u5c11\u3057\u3001\u4e0b\u6d41\u306e\u8272\u7d20\u6c88\u7740\u304c\u4f4e\u6e1b\u3055\u308c\u307e\u3059\u3002<\/p>\n\n      <h3>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9 \u2014 \u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u79fb<\/h3>\n\n      <p>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\uff08\u30d3\u30bf\u30df\u30f3B3\uff09\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u306e\u4e0b\u6d41\u3001\u3059\u306a\u308f\u3061\u8ee2\u79fb\u6bb5\u968e\u3067\u4f5c\u7528\u3057\u307e\u3059\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u79fb\u306b\u95a2\u9023\u3059\u308b\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3068\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u8abf\u7bc0\u3092\u542b\u3080\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8ee2\u79fb\u3092\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306e\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u4f9b\u7d66\u3092\u5236\u9650\u3057\u3001\u305d\u3053\u3067\u76ee\u306b\u898b\u3048\u308b\u8272\u7d20\u6c88\u7740\u306b\u5bc4\u4e0e\u3057\u307e\u3059\uff08Hakozaki et al., 2002\uff09\u3002<\/p>\n\n      <p>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3084\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u76f4\u63a5\u963b\u5bb3\u3057\u307e\u305b\u3093\u3002\u30e1\u30e9\u30cb\u30f3\u304c\u751f\u6210\u3055\u308c\u305f\u5f8c\u306b\u4ecb\u5165\u3057\u3001\u76ee\u306b\u898b\u3048\u308b\u3088\u3046\u306b\u306a\u308b\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u5c64\u306b\u5230\u9054\u3059\u308b\u91cf\u3092\u6e1b\u3089\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u6539\u5584\u3092\u901a\u3058\u3066\u9593\u63a5\u7684\u306a\u6297\u708e\u75c7\u30b5\u30dd\u30fc\u30c8\u306b\u3082\u5bc4\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u53cd\u5fdc\u6027\u304a\u3088\u3073\u654f\u611f\u808c\u306e\u30b3\u30f3\u30c6\u30ad\u30b9\u30c8\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n      <h2>\u30e1\u30ab\u30cb\u30ba\u30e0\u6bd4\u8f03<\/h2>\n\n      <div class=\"table-wrap\">\n        <table>\n          <thead>\n            <tr>\n              <th>\u30d1\u30e9\u30e1\u30fc\u30bf<\/th>\n              <th>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3<\/th>\n              <th>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/th>\n            <\/tr>\n          <\/thead>\n          <tbody>\n            <tr>\n              <td>\u4e3b\u8981\u30e1\u30ab\u30cb\u30ba\u30e0<\/td>\n              <td>\u975e\u7af6\u5408\u7684\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3<\/td>\n              <td>\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u79fb\u306e\u4f4e\u6e1b<\/td>\n            <\/tr>\n            <tr>\n              <td>\u4e0a\u6d41\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/td>\n              <td>PKA\/MITF &amp; MAPK\/MITF\u7d4c\u8def\u6291\u5236\uff1bMITF\u2193\uff1bCOX\/PGE\u2082\u8abf\u7bc0<\/td>\n              <td>\u76f4\u63a5\u7684\u306a\u4e0a\u6d41\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6d3b\u6027\u306a\u3057<\/td>\n            <\/tr>\n            <tr>\n              <td>\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u79fb\u3092\u6a19\u7684\u3068\u3059\u308b\u304b\uff1f<\/td>\n              <td>\u3044\u3044\u3048<\/td>\n              <td>\u306f\u3044 \u2014 \u8ee2\u79fb\u4f4e\u6e1b\u306b\u95a2\u9023<\/td>\n            <\/tr>\n            <tr>\n              <td>\u6297\u708e\u75c7\u4f5c\u7528\u306f\u3042\u308b\u304b\uff1f<\/td>\n              <td>\u306f\u3044 \u2014 COX\/PGE\u2082\u7d4c\u8def\u8abf\u7bc0<\/td>\n              <td>\u306f\u3044 \u2014 \u9593\u63a5\u7684\u306a\u6297\u708e\u75c7\u4f5c\u7528\uff08\u30d0\u30ea\u30a2\u5a92\u4ecb\uff09<\/td>\n            <\/tr>\n            <tr>\n              <td>\u76ee\u306b\u898b\u3048\u308b\u8272\u7d20\u6c88\u7740\u306b\u5bfe\u51e6\u3059\u308b\u304b\uff1f<\/td>\n              <td>\u9593\u63a5\u7684\u306b\uff08\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3092\u4f4e\u6e1b \u2192 \u8ee2\u79fb\u8ca0\u8377\u3092\u4f4e\u6e1b\uff09<\/td>\n              <td>\u3088\u308a\u76f4\u63a5\u7684\u306b\uff08\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u79fb\u3092\u4f4e\u6e1b\uff09<\/td>\n            <\/tr>\n            <tr>\n              <td>\u88fd\u5264\u5316\u6bb5\u968e<\/td>\n              <td>\u6cb9\/\u30dd\u30ea\u30aa\u30fc\u30eb\u76f8\uff08\u6a19\u6e96\u30b0\u30ec\u30fc\u30c9\uff09\uff1b\u6c34\u76f8\uff0810% HP-\u03b2-CD\u30b0\u30ec\u30fc\u30c9\uff09<\/td>\n              <td>\u6c34\u76f8<\/td>\n            <\/tr>\n            <tr>\n              <td>\u9069\u5408\u3059\u308bpH\u7bc4\u56f2<\/td>\n              <td>\u7d04pH 4.0\u20136.5<\/td>\n              <td>\u7d04pH 5.0\u20137.0<\/td>\n            <\/tr>\n          <\/tbody>\n        <\/table>\n      <\/div>\n\n      <h2>\u88dc\u5b8c\u7684\u306a\u8ad6\u7406<\/h2>\n\n      <p>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u8ee2\u79fb\u53ef\u80fd\u306a\u30e1\u30e9\u30cb\u30f3\u306e\u91cf\u3092\u6e1b\u3089\u3057\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u306e\u8ee2\u79fb\u3092\u6e1b\u3089\u3057\u307e\u3059\u3002\u4e21\u65b9\u3092\u4e00\u7dd2\u306b\u4f7f\u7528\u3059\u308b\u3068\u3001\u305d\u306e\u7d44\u307f\u5408\u308f\u305b\u52b9\u679c\u306f\u3001\u751f\u6210\u306e\u4f4e\u6e1b\u3068\u8ee2\u79fb\u306e\u4f4e\u6e1b\u3068\u3044\u3046\u4e21\u65b9\u306e\u6a5f\u80fd\u6bb5\u968e\u3067\u4f5c\u7528\u3057\u3001\u5358\u72ec\u3067\u4f7f\u7528\u3059\u308b\u5834\u5408\u3068\u6bd4\u8f03\u3057\u3066\u3001\u8272\u7d20\u6c88\u7740\u306e\u5f62\u6210\u3068\u5206\u5e03\u306e\u3088\u308a\u5e83\u7bc4\u306a\u5236\u5fa1\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>\n\n      <p>2026\u5e74\u306e\u7814\u7a76\uff08Pharmaceuticals\uff09\u3067\u306f\u3001\u03b1-MSH\u51e6\u7406\u3055\u308c\u305f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u306b\u304a\u3044\u3066\u3001\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306e\u4e21\u65b9\u304c\u6a39\u72b6\u7a81\u8d77\u306e\u5f62\u6210\u3068\u4f38\u9577\u3092\u6291\u5236\u3057\u3001UVB\u7167\u5c04\u3055\u308c\u305f\u5171\u57f9\u990a\u7cfb\u3067\u306f\u3001\u4e21\u65b9\u3068\u3082Rho GTPase\u306e\u8abf\u7bc0\u3092\u901a\u3058\u3066\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u3078\u306e\u30e1\u30e9\u30cb\u30f3\u8ee2\u79fb\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u3055\u3089\u306b\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u3053\u308c\u30892\u3064\u306e\u6709\u52b9\u6210\u5206\u304c\u3001\u8ee2\u79fb\u6bb5\u968e\u306b\u304a\u3044\u3066\u3082\u30e1\u30ab\u30cb\u30ba\u30e0\u7684\u306b\u7570\u306a\u308b\u304c\u6f5c\u5728\u7684\u306b\u88dc\u5b8c\u7684\u306a\u52b9\u679c\u3092\u6301\u3064\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\uff08Fang et al., 2026\uff09\u3002<\/p>\n\n      <h2>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306e\u8ffd\u52a0\u7684\u306a\u526f\u6b21\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8<\/h2>\n\n      <p>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u8272\u7d20\u6c88\u7740\u8abf\u7bc0\u306b\u304a\u3051\u308b\u5f79\u5272\u3060\u3051\u3067\u306a\u304f\u3001\u8ffd\u52a0\u7684\u306a\u76ae\u819a\u5065\u5eb7\u6a5f\u80fd\u3092\u901a\u3058\u3066\u3001\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u88fd\u5264\u306b\u8ca2\u732e\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4e8c\u6b21\u7684\u306a\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u5264\u3067\u306f\u306a\u304f\u3001\u591a\u6a5f\u80fd\u306a\u6709\u52b9\u6210\u5206\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n      <ul>\n        <li><strong>\u30d0\u30ea\u30a2\u6a5f\u80fd\u30b5\u30dd\u30fc\u30c8\uff1a<\/strong> \u30bb\u30e9\u30df\u30c9\u5408\u6210\u3092\u523a\u6fc0\u3057\u3001\u89d2\u8cea\u5c64\u306e\u5b8c\u5168\u6027\u3092\u6539\u5584\u3057\u307e\u3059 \u2014 \u654f\u611f\u808c\u304a\u3088\u3073\u53cd\u5fdc\u6027\u808c\u7528\u88fd\u5264\u306b\u76f4\u63a5\u95a2\u9023\u3057\u307e\u3059<\/li>\n        <li><strong>\u76ae\u8102\u8abf\u7bc0\uff1a<\/strong> \u76ae\u8102\u817a\u306e\u6d3b\u52d5\u8abf\u7bc0\u3092\u901a\u3058\u3066\u76ae\u8102\u751f\u6210\u3092\u4f4e\u6e1b\u3057\u307e\u3059 \u2014 \u6cb9\u6027\u808c\u304a\u3088\u3073\u30cb\u30ad\u30d3\u95a2\u9023\u88fd\u5264\u306b\u95a2\u9023\u3057\u307e\u3059<\/li>\n        <li><strong>\u6bdb\u7a74\u306e\u5916\u89b3\uff1a<\/strong> \u7d99\u7d9a\u7684\u306a\u4f7f\u7528\u306b\u3088\u308a\u3001\u76ee\u306b\u898b\u3048\u308b\u6bdb\u7a74\u306e\u30b5\u30a4\u30ba\u30925\uff5e10%\u4f4e\u6e1b<\/li>\n        <li><strong>\u5fc3\u3092\u843d\u3061\u7740\u304b\u305b\u308b\uff1a<\/strong> \u30d0\u30ea\u30a2\u6539\u5584\u306b\u3088\u308b\u9593\u63a5\u7684\u306a\u6297\u708e\u75c7\u4f5c\u7528\u306f\u3001\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u76ae\u819a\u306e\u53cd\u5fdc\u6027\u3092\u4f4e\u6e1b\u3057\u307e\u3059<\/li>\n      <\/ul>\n\n      <p>\u3053\u308c\u3089\u306e\u526f\u6b21\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u304c\u8272\u7d20\u6c88\u7740\u8abf\u7bc0\u306b\u304a\u3051\u308b\u5f79\u5272\u3060\u3051\u3067\u306a\u304f\u3001\u8ffd\u52a0\u7684\u306a\u76ae\u819a\u5065\u5eb7\u6a5f\u80fd\u3092\u901a\u3058\u3066\u3001\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u88fd\u5264\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4e8c\u6b21\u7684\u306a\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u5264\u3067\u306f\u306a\u304f\u3001\u591a\u6a5f\u80fd\u306a\u6709\u52b9\u6210\u5206\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n      <h2>\u88fd\u5264\u9069\u5408\u6027<\/h2>\n\n      <p>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u540c\u3058\u88fd\u5264\u4e2d\u3067\u76f4\u63a5\u9069\u5408\u3057\u307e\u3059\u3002\u305d\u308c\u3089\u306epH\u30a6\u30a3\u30f3\u30c9\u30a6\u306f\u7d04pH 5.0\u301c6.0\u3067\u91cd\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u7bc4\u56f2\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u654f\u611f\u808c\u304a\u3088\u3073\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u7528\u6d17\u3044\u6d41\u3055\u306a\u3044\u88fd\u5264\u306b\u3082\u9069\u3057\u3066\u3044\u307e\u3059\u3002\u4e21\u6709\u52b9\u6210\u5206\u9593\u306b\u7269\u7406\u5316\u5b66\u7684\u306a\u4e0d\u9069\u5408\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n      <p><strong>\u88fd\u5264\u306b\u95a2\u3059\u308b\u6ce8\u610f\uff1a<\/strong> \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u540c\u3058\u88fd\u5264\u4e2d\u3067\u9069\u5408\u3057\u307e\u3059\u304c\u3001\u5168\u4f53\u306e\u5b89\u5b9a\u6027\u306f\u3001pH\u3001\u9178\u5316\u9632\u6b62\u3001\u30d1\u30c3\u30b1\u30fc\u30b8\u30f3\u30b0\u3001\u305d\u306e\u4ed6\u306e\u6709\u52b9\u6210\u5206\u3092\u542b\u3080\u5b8c\u5168\u306a\u30b7\u30b9\u30c6\u30e0\u306b\u57fa\u3065\u3044\u3066\u8a55\u4fa1\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n      <h3>\u63a8\u5968\u4f7f\u7528\u91cf<\/h3>\n\n      <div class=\"table-wrap\">\n        <table>\n          <thead>\n            <tr>\n              <th>\u6709\u52b9\u6210\u5206<\/th>\n              <th>\u63a8\u5968\u7bc4\u56f2<\/th>\n              <th>\u6ce8\u8a18<\/th>\n            <\/tr>\n          <\/thead>\n          <tbody>\n            <tr>\n              <td><strong>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3<\/strong><\/td>\n              <td>\u5b8c\u6210\u54c1\u4e2d\u306e\u6709\u52b9\u6210\u5206 0.1\u20130.5%<\/td>\n              <td>03% \u3067\u81e8\u5e8a\u30c7\u30fc\u30bf\u3042\u308a\u3002\u3088\u308a\u96c6\u4e2d\u7684\u306a\u8272\u7d20\u6c88\u7740\u306e\u554f\u984c\u306b\u306f\u3001\u3088\u308a\u9ad8\u6fc3\u5ea6\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u3067\u3059\u3002<\/td>\n            <\/tr>\n            <tr>\n              <td><strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/strong><\/td>\n              <td>2\u201310%<\/td>\n              <td>\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u3068\u30d0\u30ea\u30a2\u30b5\u30dd\u30fc\u30c8\uff1a2\u20135%\u3002\u76ae\u8102\u8abf\u7bc0\u3068\u6bdb\u7a74\u306e\u5916\u89b3\u6539\u5584\uff1a\u4e00\u822c\u7684\u306b 5\u201310% \u3067\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/td>\n            <\/tr>\n          <\/tbody>\n        <\/table>\n      <\/div>\n\n      <p>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u69d8\u3005\u306a\u76ae\u819a\u3078\u306e\u52b9\u679c\u306b\u304a\u3044\u3066\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306a\u52b9\u679c\u3092\u6301\u3064\u3001\u3088\u304f\u7814\u7a76\u3055\u308c\u305f\u5316\u7ca7\u54c1\u6709\u52b9\u6210\u5206\u306e\u4e00\u3064\u3067\u3059\u304c\u3001\u6700\u9069\u306a\u30ec\u30d9\u30eb\u306f\u7279\u5b9a\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u30022% \u3067\u306f\u3001\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u52b9\u679c\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3059\u30025% \u5468\u8fba\u3067\u306f\u3001\u30d0\u30ea\u30a2\u30b5\u30dd\u30fc\u30c8\u3068\u76ae\u8102\u95a2\u9023\u306e\u52b9\u679c\u304c\u4e00\u822c\u7684\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3088\u308a\u9ad8\u6fc3\u5ea6\uff08\u4f8b\uff1a10%\uff09\u304c\u4e00\u90e8\u306e\u88fd\u5264\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4e00\u90e8\u306e\u30e6\u30fc\u30b6\u30fc\u3067\u306f\u523a\u6fc0\u3084\u611f\u5ea6\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n      <h2>\u5b8c\u5168\u306a\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u30b7\u30b9\u30c6\u30e0\u8a2d\u8a08<\/h2>\n\n      <p>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u5b8c\u5168\u306a\u591a\u6bb5\u968e\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u30b7\u30b9\u30c6\u30e0\u306b\u304a\u3051\u308b 5 \u3064\u306e\u4e3b\u8981\u30ce\u30fc\u30c9\u306e\u3046\u3061\u306e 2 \u3064\u3092\u5f62\u6210\u3057\u307e\u3059\u3002TXA\u3001\u5b89\u5b9a\u578b\u30d3\u30bf\u30df\u30f3 C \u8a98\u5c0e\u4f53\u3001\u304a\u3088\u3073\u30d0\u30ea\u30a2\u6d3b\u6027\u6210\u5206\u3068\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001\u3053\u306e\u30b7\u30b9\u30c6\u30e0\u306f\u8272\u7d20\u6c88\u7740\u7d4c\u8def\u306e\u4e3b\u8981\u306a\u4fee\u98fe\u53ef\u80fd\u306a\u6bb5\u968e\u3092\u7db2\u7f85\u3057\u307e\u3059\u3002<\/p>\n\n      <div class=\"table-wrap\">\n        <table>\n          <thead>\n            <tr>\n              <th>\u7d4c\u8def\u6bb5\u968e<\/th>\n              <th>\u6709\u52b9\u6210\u5206<\/th>\n              <th>\u6a5f\u69cb<\/th>\n            <\/tr>\n          <\/thead>\n          <tbody>\n            <tr>\n              <td>\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\uff08\u4e0a\u6d41\uff09<\/td>\n              <td>TXA<\/td>\n              <td>\u30d7\u30e9\u30b9\u30df\u30ce\u30fc\u30b2\u30f3\u7d4c\u8def\u963b\u5bb3\uff1b\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4f4e\u6e1b<\/td>\n            <\/tr>\n            <tr>\n              <td>\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u6d3b\u6027\u5316 \/ MITF<\/td>\n              <td>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3<\/td>\n              <td>PKA\/MITF \u304a\u3088\u3073 MAPK\/MITF \u7d4c\u8def\u6291\u5236\uff1bMITF\u2193<\/td>\n            <\/tr>\n            <tr>\n              <td>\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027<\/td>\n              <td>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3<\/td>\n              <td>\u975e\u7af6\u5408\u7684\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3<\/td>\n            <\/tr>\n            <tr>\n              <td>\u30e1\u30e9\u30cb\u30f3\u5408\u6210<\/td>\n              <td>AA-2G \u307e\u305f\u306f MAP\uff08\u5b89\u5b9a\u578b\u30d3\u30bf\u30df\u30f3 C\uff09<\/td>\n              <td>\u30c9\u30fc\u30d1\u30ad\u30ce\u30f3\u3078\u306e\u6297\u9178\u5316\u9084\u5143\u304a\u3088\u3073\u30e1\u30e9\u30cb\u30f3\u91cd\u5408\u306e\u963b\u5bb3<\/td>\n            <\/tr>\n            <tr>\n              <td>\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u79fb<\/td>\n              <td>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/td>\n              <td>\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u9001\u3092\u4f4e\u6e1b<\/td>\n            <\/tr>\n          <\/tbody>\n        <\/table>\n      <\/div>\n\n      <figure class=\"figure\">\n        <img decoding=\"async\" src=\"https:\/\/glabridinchina.com\/wp-content\/uploads\/2026\/06\/glabridin_5node_pathway.png\"\n             alt=\"UV \u523a\u6fc0\u304b\u3089\u76ee\u306b\u898b\u3048\u308b\u8272\u7d20\u6c88\u7740\u307e\u3067\u306e 8 \u30b9\u30c6\u30c3\u30d7\u306e\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u7d4c\u8def\u5168\u4f53\u3092\u793a\u3059\u56f3\u30025 \u3064\u306e\u4ecb\u5165\u30dd\u30a4\u30f3\u30c8\uff1aTXA\u3001\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\uff08COX\/PGE\u2082\uff09\u3001\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\uff08PKA\/MITF\uff09\u3001\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\uff08\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\uff09\u3001\u5b89\u5b9a\u578b\u30d3\u30bf\u30df\u30f3 C\u3001\u304a\u3088\u3073\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3002\">\n        <figcaption>\u56f3 1 \u2014 5 \u30ce\u30fc\u30c9\u306e\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u30b7\u30b9\u30c6\u30e0\uff1a\u5b8c\u5168\u306a\u7d4c\u8def\u306b\u308f\u305f\u308b\u8272\u7d20\u6c88\u7740\u30ab\u30d0\u30fc\u3002\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u8907\u6570\u306e\u30ec\u30d9\u30eb\u306b\u4ecb\u5165\u3057\u307e\u3059 \u2014 COX\/PGE\u2082 \u30e2\u30b8\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3001PKA\/MITF \u7d4c\u8def\u6291\u5236\u3001\u304a\u3088\u3073\u975e\u7af6\u5408\u7684\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u3002\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u9001\u3092\u4f4e\u6e1b\u3057\u307e\u3059\u3002\u51fa\u5178\uff1aYokota et al., 1998; Pan et al., 2023; Hakozaki et al., 2002; Nerya et al., 2003\u3002<\/figcaption>\n      <\/figure>\n\n      <p>\u3053\u306e 5 \u70b9\u30b7\u30b9\u30c6\u30e0 \u2014 TXA + \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3 + \u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9 + \u5b89\u5b9a\u578b\u30d3\u30bf\u30df\u30f3 C \u8a98\u5c0e\u4f53 \u2014 \u306f\u3001\u4e92\u63db\u6027\u306e\u3042\u308b pH \u30a6\u30a3\u30f3\u30c9\u30a6\uff084.5\u20136.0\uff09\u5185\u3067\u3001\u8272\u7d20\u6c88\u7740\u751f\u7269\u5b66\u306b\u304a\u3051\u308b\u4e3b\u8981\u306a\u4fee\u98fe\u53ef\u80fd\u306a\u30ce\u30fc\u30c9\u3092\u5305\u62ec\u7684\u306b\u30ab\u30d0\u30fc\u3057\u307e\u3059\u3002<\/p>\n\n      <h2>\u5fdc\u7528\u30b3\u30f3\u30c6\u30ad\u30b9\u30c8<\/h2>\n\n      <div class=\"table-wrap\">\n        <table>\n          <thead>\n            <tr>\n              <th>\u5fdc\u7528<\/th>\n              <th>\u6839\u62e0<\/th>\n            <\/tr>\n          <\/thead>\n          <tbody>\n            <tr>\n              <td>\u30cb\u30ad\u30d3\u5f8c\u306e PIH \u4fee\u5fa9<\/td>\n              <td>\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\uff08\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3 + \u6297\u708e\u75c7\u6d3b\u6027\uff09\u306f\u708e\u75c7\u8d77\u6e90\u306b\u5bfe\u51e6\u3057\u307e\u3059\uff1b\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u9001\u3092\u4f4e\u6e1b\u3057\u307e\u3059\uff1b\u30d0\u30ea\u30a2\u6a5f\u80fd\u30b5\u30dd\u30fc\u30c8\u306f\u56de\u5fa9\u3092\u52a9\u3051\u307e\u3059<\/td>\n            <\/tr>\n            <tr>\n              <td>FITZPATRICK III\u2013VI \u3092\u5bfe\u8c61\u3068\u3057\u305f\u88fd\u54c1<\/td>\n              <td>PIH \u3068\u8272\u7d20\u5206\u5e03\u304c\u4e3b\u306a\u61f8\u5ff5\u4e8b\u9805\u3067\u3059\uff1b\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3 + \u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u751f\u6210\u3068\u8ee2\u9001\u306e\u4e21\u65b9\u306b\u5bfe\u51e6\u3057\u307e\u3059<\/td>\n            <\/tr>\n            <tr>\n              <td>\u654f\u611f\u808c\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0<\/td>\n              <td>\u4e21\u65b9\u306e\u6d3b\u6027\u6210\u5206\u306f\u5341\u5206\u306b\u8010\u5bb9\u6027\u304c\u3042\u308a\u307e\u3059\uff1b\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306e\u30d0\u30ea\u30a2\u30b5\u30dd\u30fc\u30c8\u306f\u3001\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u3068\u4e26\u884c\u3057\u3066\u76ae\u819a\u306e\u56de\u5fa9\u3092\u7a4d\u6975\u7684\u306b\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059<\/td>\n            <\/tr>\n            <tr>\n              <td>\u4e00\u822c\u7684\u306a\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u7dad\u6301<\/td>\n              <td>\u30b3\u30b9\u30c8\u52b9\u7387\u306e\u9ad8\u3044\u591a\u6bb5\u968e\u30b7\u30b9\u30c6\u30e0\u3067\u3001\u5e45\u5e83\u3044\u88fd\u5264\u9069\u5408\u6027\u304c\u3042\u308a\u307e\u3059<\/td>\n            <\/tr>\n            <tr>\n              <td>\u30aa\u30a4\u30ea\u30fc\u808c \/ \u30cb\u30ad\u30d3\u95a2\u9023\u306e\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0<\/td>\n              <td>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u76ae\u8102\u8abf\u7bc0\u3092\u8ffd\u52a0\u3057\u307e\u3059\uff1b\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u6297\u708e\u75c7\u30b5\u30dd\u30fc\u30c8\u3092\u8ffd\u52a0\u3057\u307e\u3059<\/td>\n            <\/tr>\n          <\/tbody>\n        <\/table>\n      <\/div>\n\n      <div class=\"callout\">\n        <p>\u3059\u3079\u3066\u306e\u30d0\u30c3\u30c1\u306b\u306f\u3001COA\u3001TDS\u3001\u304a\u3088\u3073SDS\/MSDS\u304c\u540c\u68b1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8ffd\u52a0\u306e\u30c6\u30b9\u30c8\u3082\u30ea\u30af\u30a8\u30b9\u30c8\u306b\u5fdc\u3058\u3066\u5229\u7528\u53ef\u80fd\u3067\u3059\u3002<\/p>\n      <\/div>\n\n      <!-- Related -->\n      <div class=\"related-section\">\n        <h2>Related Resources<\/h2>\n        <div class=\"related-links\">\n          <a class=\"related-link\" href=\"https:\/\/glabridinchina.com\/ja\/glabridin\/\">\n            <span>\u5316\u7ca7\u54c1\u88fd\u5264\u7528\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u30ac\u30a4\u30c9 \u2014 \u5b8c\u5168\u6280\u8853\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9<br>\n            <small style=\"color:var(--color-text-muted);font-weight:400\">\u5b8c\u5168\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3001PKA\/MITF \u7d4c\u8def\u30c7\u30fc\u30bf\u3001\u30b0\u30ec\u30fc\u30c9\u30de\u30c8\u30ea\u30c3\u30af\u30b9<\/small><\/span>\n   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style=\"color:var(--color-text-muted);font-weight:400\">\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u52b9\u529b\u306e\u6bd4\u8f03<\/small><\/span>\n            <span class=\"related-link-arrow\">\u2192<\/span>\n          <\/a>\n          <a class=\"related-link\" href=\"https:\/\/glabridinchina.com\/ja\/can-glabridin-be-used-in-sensitive-skin-products\/\">\n            <span>\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u306f\u654f\u611f\u808c\u7528\u88fd\u54c1\u306b\u4f7f\u7528\u3067\u304d\u307e\u3059\u304b\uff1f<br>\n            <small style=\"color:var(--color-text-muted);font-weight:400\">PIH\u7ba1\u7406\u3068\u6297\u708e\u75c7\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0<\/small><\/span>\n            <span class=\"related-link-arrow\">\u2192<\/span>\n          <\/a>\n        <\/div>\n      <\/div>\n\n      <!-- CTA -->\n      <div class=\"cta-box\">\n        <div class=\"cta-box-text\">\n          <strong>\u30b5\u30f3\u30d7\u30eb\u3001COA\u3001\u307e\u305f\u306f\u6280\u8853\u30b3\u30f3\u30b5\u30eb\u30c6\u30fc\u30b7\u30e7\u30f3\u3092\u30ea\u30af\u30a8\u30b9\u30c8\u3059\u308b<\/strong>\n          glabridinchina.com \u00b7 jelly@huataibio.com \u00b7 +86 17868678161\n        <\/div>\n        <a class=\"cta-btn\" href=\"https:\/\/glabridinchina.com\/ja\/product-tag\/\">\u304a\u554f\u3044\u5408\u308f\u305b \u2192<\/a>\n      <\/div>\n\n      <!-- References -->\n      <div class=\"references\">\n        <h2>\u53c2\u8003\u6587\u732e<\/h2>\n        <ol>\n          <li>Yokota T, Nishio H, Kubota Y, Mizoguchi M. The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. <em>Pigment Cell Research<\/em>\u3001 11(6)\u3001 355\u2013361\u3001 1998\u5e74\u3002 DOI: 10.1111\/j.1600-0749.1998.tb00494.x\u3002<\/li>\n          <li>Pan C, Liu X, Zheng Y, et al. \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306b\u3088\u308b\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u963b\u5bb3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\uff1a\u5206\u5b50\u30c9\u30c3\u30ad\u30f3\u30b0\u3001PKA\/MITF \u304a\u3088\u3073 MAPK\/MITF \u7d4c\u8def\u3002 <em>\u98df\u54c1\u79d1\u5b66\u3068\u4eba\u9593\u306e\u5065\u5eb7<\/em>\u300112(1)\u3001212\u2013222\u30012023\u3002DOI: 10.1016\/j.fshw.2022.07.011\u3002<\/li>\n          <li>Hakozaki T, Minwalla L, Zhuang J, et al. \u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u304c\u76ae\u819a\u306e\u8272\u7d20\u6c88\u7740\u3092\u4f4e\u6e1b\u3057\u3001\u30e1\u30e9\u30ce\u30bd\u30fc\u30e0\u8ee2\u9001\u3092\u6291\u5236\u3059\u308b\u52b9\u679c\u3002 <em>\u82f1\u56fd\u76ae\u819a\u79d1\u5b66\u4f1a\u8a8c<\/em>\u3001147(1)\u300120\u201331\u30012002\u3002DOI: 10.1046\/j.1365-2133.2002.04834.x\u3002<\/li>\n          <li>Fang Y, et al. \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u304a\u3088\u3073 Rho \u30d5\u30a1\u30df\u30ea\u30fc GTPase \u3092\u4ecb\u3057\u305f\u6a39\u72b6\u7a81\u8d77\u5f62\u6210\u6291\u5236\u306b\u3088\u308a\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u3068\u30e1\u30e9\u30cb\u30f3\u8ee2\u9001\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002 <em>\u533b\u85ac\u54c1<\/em>\u300119(3)\u3001469\u30012026\u3002DOI: 10.3390\/ph19030469\u3002<\/li>\n          <li>\u30cd\u30eb\u30e4 O\u3001\u30f4\u30a1\u30e4 J\u3001\u30e0\u30fc\u30b5 R\u3001\u30a4\u30ba\u30e9\u30a8\u30eb S\u3001\u30d9\u30f3\uff1d\u30a2\u30ea\u30a8 R\u3001\u30bf\u30df\u30fc\u30eb S. \u7518\u8349\u6839\u304b\u3089\u306e\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u3068\u3057\u3066\u306e\u30b0\u30e9\u30d6\u30ec\u30cd\u304a\u3088\u3073\u30a4\u30bd\u30ea\u30af\u30a4\u30ea\u30c1\u30b2\u30cb\u30f3\u3002 <em>\u8fb2\u696d\u304a\u3088\u3073\u98df\u54c1\u5316\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb<\/em>\u300151(5)\u30011201\u20131207\u30012003\u3002<\/li>\n        <\/ol>\n      <\/div>\n\n      <div class=\"article-footer\">\n        <p>\u30d7\u30ed\u306e\u5316\u7ca7\u54c1\u51e6\u65b9\u8005\u304a\u3088\u3073\u7814\u7a76\u958b\u767a\u8005\u5411\u3051\u3002 \u6cd5\u898f\u5236\u306b\u95a2\u3059\u308b\u52a9\u8a00\u3092\u69cb\u6210\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br>\n        2026\u5e74\u767a\u884c \u2014 Huatai Bio-Fine Chemical\u3001\u897f\u5b89\u3001\u965d\u897f\u7701\u3001\u4e2d\u56fd\u3002<\/p>\n      <\/div>\n\n    <\/article>\n  <\/div>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u30b8\u30ab\u30ea\u30a6\u30e0 \u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9 \u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0 \u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u9178\u30b8\u30ab\u30ea\u30a6\u30e0\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u306f\u3001\u73fe\u4ee3\u306e\u88fd\u5264\u306b\u304a\u3044\u3066\u6700\u3082\u4e00\u822c\u7684\u306b\u7d44\u307f\u5408\u308f\u3055\u308c\u308b\u30d6\u30e9\u30a4\u30c8\u30cb\u30f3\u30b0\u6709\u52b9\u6210\u5206\u306e\u3044\u304f\u3064\u304b\u3067\u3059\u3002\u305d\u308c\u3089\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u88dc\u5b8c\u7684\u306a\u5f79\u5272\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u2026<\/p>","protected":false},"author":8,"featured_media":13647,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[412],"tags":[],"class_list":["post-14226","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-comparisons"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.8 (Yoast SEO v24.2) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Glabridin &amp; Niacinamide: Complementary Mechanisms in Multilevel Brightening | Huatai Bio-Fine Chemical<\/title>\n<meta name=\"description\" content=\"Glabridin targets melanin synthesis through tyrosinase-related pathways; niacinamide reduces melanosome transfer. Together they address different stages of pigmentation \u2014 from formation to visible accumulation. From Huatai, manufacturer of high-purity glabridin since 2008.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/glabridinchina.com\/ja\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Glabridin &amp; Niacinamide: Complementary Mechanisms in Multilevel Brightening\" \/>\n<meta property=\"og:description\" content=\"Glabridin targets melanin synthesis through tyrosinase-related pathways; niacinamide reduces melanosome transfer. Together they address different stages of pigmentation \u2014 from formation to visible accumulation. From Huatai, manufacturer of high-purity glabridin since 2008.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/glabridinchina.com\/ja\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/\" \/>\n<meta property=\"og:site_name\" content=\"Shaanxi Huatai Bio-Fine Chemical Co., Ltd.\" \/>\n<meta property=\"article:published_time\" content=\"2026-06-22T09:29:47+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-22T09:37:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/glabridinchina.com\/wp-content\/uploads\/2026\/05\/Niacinamide.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"768\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Huatai\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"Huatai\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/glabridinchina.com\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/glabridinchina.com\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/\"},\"author\":{\"name\":\"Huatai\",\"@id\":\"https:\/\/glabridinchina.com\/#\/schema\/person\/1fc9183390cde309170faf98dbabcaab\"},\"headline\":\"Glabridin &amp; Niacinamide: Complementary Mechanisms in Multilevel Brightening\",\"datePublished\":\"2026-06-22T09:29:47+00:00\",\"dateModified\":\"2026-06-22T09:37:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/glabridinchina.com\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/\"},\"wordCount\":1392,\"publisher\":{\"@id\":\"https:\/\/glabridinchina.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/glabridinchina.com\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/glabridinchina.com\/wp-content\/uploads\/2026\/05\/Niacinamide.jpg\",\"articleSection\":[\"Comparisons\"],\"inLanguage\":\"ja\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/glabridinchina.com\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/\",\"url\":\"https:\/\/glabridinchina.com\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/\",\"name\":\"Glabridin & Niacinamide: Complementary Mechanisms in Multilevel Brightening | Huatai Bio-Fine Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/glabridinchina.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/glabridinchina.com\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/glabridinchina.com\/glabridin-niacinamide-complementary-mechanisms-in-multilevel-brightening\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/glabridinchina.com\/wp-content\/uploads\/2026\/05\/Niacinamide.jpg\",\"datePublished\":\"2026-06-22T09:29:47+00:00\",\"dateModified\":\"2026-06-22T09:37:06+00:00\",\"description\":\"Glabridin targets melanin synthesis through tyrosinase-related pathways; niacinamide reduces melanosome transfer. 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